Simulation and experimental study on rope driven artificial hand and driven motor.

BACKGROUND: Prosthetic hands have the potential to replace human hands. Using prosthetic hands can help patients with hand loss to complete the necessary daily living actions. OBJECTIVE: This paper studies the design of a bionic, compact, low-cost, and lightweight 3D printing humanoid hand. The five fingers are underactuated, with a total of 9 degrees of freedom. METHODS: In the design of an underactuated hand, it is a basic element composed of an actuator, spring, rope, and guide system. A single actuator is providing power for five fingers. And the dynamic simulation is carried out to calculate the motion trajectory effect. RESULTS: In this paper, the driving structure of the ultrasonic motor was designed, and the structural size of the ultrasonic motor vibrator was determined by modal and transient simulation analysis, which replace the traditional brake, realize the lightweight design of prosthetic hand, improve the motion accuracy and optimize the driving performance of prosthetic hand. CONCLUSIONS: By replacing traditional actuators with new types of actuators, lightweight design of prosthetic hands can be achieved, improving motion accuracy and optimizing the driving performance of prosthetic hands.

Simulation Analysis of a Sandwich Cantilever Ultrasonic Motor for a Dexterous Prosthetic Hand.

Currently, the driving motor used in a dexterous prosthetic hand is limited by the driving principle, and it has the characteristics of a complex structure, slow response, low positioning accuracy, and excessive volume. There are special requirements in terms of quality and quality, and traditional motor drives have greatly affected the progress of prosthetic robots. A motor (ultrasonic motor) has been developed over more than 30 years. It has the advantages of a small size, small mass, simple structure, accurate positioning, high power density, and fast response time, which is enough to improve the driving mechanism performance of the prosthetic hand with a connecting rod. In this paper, the structural characteristics of the prosthetic hand will be analyzed, and the modal analysis, harmonic response analysis, and transient analysis simulation of the longitudinal vibration linear motor stator used in the prosthetic hand with a connecting rod will be carried out in order to provide preliminary preparation for the feasible design and manufacture of the size of the ultrasonic driver structure used for the prosthetic hand with a connecting rod.

Dynamic Analysis and Experimental Study of Lasso Transmission for Hand Rehabilitation Robot.

Lasso transmission is a method for realizing long-distance flexible transmission and lightweight robots. However, there are transmission characteristic losses of velocity, force, and displacement during the motion of lasso transmission. Therefore, the analysis of transmission characteristic losses of lasso transmission has become the focus of research. For this study, at first, we developed a new flexible hand rehabilitation robot with a lasso transmission method. Second, the theoretical analysis and simulation analysis of the dynamics of the lasso transmission in the flexible hand rehabilitation robot were carried out to calculate the force, velocity, and displacement losses of the lasso transmission. Finally, the mechanism and transmission models were established for experimental studies to measure the effects of different curvatures and speeds on the lasso transmission torque. The experimental data and image analysis results show torque loss in the process of lasso transmission and an increase in torque loss with the increase in the lasso curvature radius and transmission speed. The study of the lasso transmission characteristics is important for the design and control of hand functional rehabilitation robots, providing an important reference for the design of flexible rehabilitation robots and also guiding the research on the lasso regarding the compensation method for transmission losses.

Empowering Hand Rehabilitation with AI-Powered Gesture Recognition: A Study of an sEMG-Based System.

Stroke is one of the most prevalent health issues that people face today, causing long-term complications such as paresis, hemiparesis, and aphasia. These conditions significantly impact a patient's physical abilities and cause financial and social hardships. In order to address these challenges, this paper presents a groundbreaking solution-a wearable rehabilitation glove. This motorized glove is designed to provide comfortable and effective rehabilitation for patients with paresis. Its unique soft materials and compact size make it easy to use in clinical settings and at home. The glove can train each finger individually and all fingers together, using assistive force generated by advanced linear integrated actuators controlled by sEMG signals. The glove is also durable and long-lasting, with 4-5 h of battery life. The wearable motorized glove is worn on the affected hand to provide assistive force during rehabilitation training. The key to this glove's effectiveness is its ability to perform the classified hand gestures acquired from the non-affected hand by integrating four sEMG sensors and a deep learning algorithm (the 1D-CNN algorithm and the InceptionTime algorithm). The InceptionTime algorithm classified ten hand gestures' sEMG signals with an accuracy of 91.60% and 90.09% in the training and verification sets, respectively. The overall accuracy was 90.89%. It showed potential as a tool for developing effective hand gesture recognition systems. The classified hand gestures can be used as a control command for the motorized wearable glove placed on the affected hand, allowing it to mimic the movements of the non-affected hand. This innovative technology performs rehabilitation exercises based on the theory of mirror therapy and task-oriented therapy. Overall, this wearable rehabilitation glove represents a significant step forward in stroke rehabilitation, offering a practical and effective solution to help patients recover from stroke's physical, financial, and social impact.

Erratum to: Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met.

The online version of the original article can be found at https://doi.org/10.1631/jzus.B2000190 Erratum to: J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2020 21(10):779-795 https://doi.org/10.1631/jzus.B2000190.

Design of a Millimeter-Wave Radar Remote Monitoring System for the Elderly Living Alone Using WIFI Communication.

In response to the current demand for the remote monitoring of older people living alone, a non-contact human vital signs monitoring system based on millimeter wave radar has gradually become the object of research. This paper mainly carried out research regarding the detection method to obtain human breathing and heartbeat signals using a frequency modulated continuous wave system. We completed a portable millimeter-wave radar module for wireless communication. The radar module was a small size and had a WIFI communication interface, so we only needed to provide a power cord for the radar module. The breathing and heartbeat signals were detected and separated by FIR digital filter and the wavelet transform method. By building a cloud computing framework, we realized remote and senseless monitoring of the vital signs for older people living alone. Experiments were also carried out to compare the performance difference between the system and the common contact detection system. The experimental results showed that the life parameter detection system based on the millimeter wave sensor has strong real-time performance and accuracy.

Verticillin A inhibits colon cancer cell migration and invasion by targeting c-Met.

Verticillin A is a diketopiperazine compound which was previously isolated from Amanita flavorubescens Alk (containing parasitic fungi Hypomyces hyalines (Schw.) Tul.). Here, we initially found, by wound healing assay and Transwell assay in vitro, that verticillin A possesses an inhibitory effect against the migration and invasion of the human colon cancer cell. Subsequently, c-mesenchymal-epithelial transition factor (c-Met) was identified as a molecular target of verticillin A by screening key genes related to cell migration. Verticillin A-mediated c-Met suppression is at the transcriptional level. Further study demonstrated that verticillin A suppressed c-MET phosphorylation and decreased c-MET protein level. In addition, verticillin A inhibited the phosphorylation of c-MET downstream molecules including rat sarcoma (Ras)-associated factor (Raf), extracellular signal-regulated kinase (ERK), and protein kinase B (AKT). Overexpression of Erk partially reversed the verticillin A-mediated anti-metastasis action in the human colon cancer cell. More importantly, verticillin A also inhibited cancer cell metastasis in vivo. Thus, verticillin A can significantly inhibit the migration and invasion of colon cancer cells by targeting c-Met and inhibiting Ras/Raf/mitogen-activated extracellular signal-regulated kinase (MEK)/ERK signaling pathways. Therefore, we determined that verticillin A is a natural compound that can be further developed as an anti-metastatic drug in human cancers.

Verticillin A suppresses HGF-induced migration and invasion via repression of the c-Met/FAK/Src pathway in human gastric and cervical cancer cells.

Background and purpose: Verticillin A is a fungal epipolythiodioxopiperazine (ETP) metabolite that was isolated from Amanita flavorubescens Alk infected by Verticillium sp. It was previously proven to possess potent anti-tumor cell growth activity, and we have recently determined that verticillin A is a selective inhibitor of H3K9me3-specific histone methyltransferase. The objective of this study was to find out whether verticillin A is an effective agent for suppression of gastric and cervical tumor progression. Materials and methods: Wound healing and transwell assays was performed to evaluate the effect of verticillin A on hepatocyte growth factor (HGF)-induced AGS and HeLa cells migration and invasion in vitro. Western blot was used to detect signaling proteins verticillin A affected. Results: We determined that verticillin A effectively suppressed hepatocyte growth factor (HGF)-induced AGS and HeLa cells migration and invasion in vitro. At the molecular level, we demonstrated that verticillin A inhibited HGF-induced c-Met phosphorylation and repressed the expression of total c-Met protein in AGS and HeLa cells, resulting from reduced expression of fatty acid synthase. In addition, verticillin A could suppress c-Met downstream FAK/Src signaling pathways by impairing c-Met phosphorylation induced by HGF. Conclusion: Our study demonstrated verticillin A inhibits the migration ability of human gastric cancer (AGS) cells and cervical cancer (HeLa) cells by targeting c-Met and its downstream FAK/Src signaling pathways, and suggested that verticillin A acts as a novel HGF/c-Met inhibitor by reducing expression of this receptor.

Chemical synthesis and functional characterization of a new class of ceramide analogues as anti-cancer agents.

Deregulation of ceramide metabolism is a hallmark of human cancer. Ceramide analogues thereby represent a new class of anti-cancer agents. We aimed at developing effective and low toxic ceramide analogues and synthesized a new class of ceramide analogues starting from l-threonine. Several analogues exhibit potent cytotoxicity against human cancer cells in vitro with IC50 as low as 4.8 µM. These ceramide analogues decreased xIAP and Bcl-xL level and exhibited significant sensitization activity to overcome human cancer cell resistance to TRAIL, a cancer-selective agent that are being tested in human clinical trials. Furthermore, we determined that these ceramide analogues effectively suppress human cancer xenograft growth in vivo with no significant toxicity at the efficacious dose. Therefore, we have developed a simple and effective method to synthesize functional ceramide analogues using l-threonine as starting material and these analogues have the great potential to be further developed as anti-cancer agents in human cancer therapy.