RESUMEN
Heterogeneous interface construction is of far-reaching significance to optimize the electrochemical performance of electrodes. Herein, a multi-step alternating electrochemical deposition (MAED) method is proposed to alternately deposit Co0.85Se and Ni3S4 nanosheets on a nickel foam (NF), forming a special alternate layer-by-layer structure with multi-layered heterogeneous interfaces. The creation of the multi-layered heterogeneous interfaces provides a large interfacial area for redox reactions with optimum interstitials facilitating ion diffusion, thus greatly improving the electrochemical energy storage efficiency. With the increase in the layer number, the material exhibits increasingly better energy storage performance, and 8L-Co0.85Se@Ni3S4/NF exhibits the highest specific capacitances of 2508 F g-1 and 1558 F g-1 at a scan rate of 2 mV s-1 and a current density of 1 A g-1. The 8L-Co0.85Se@Ni3S4/NF//polypyrrole (PPy)/NF asymmetric supercapacitor provides a maximum operation potential window of 1.55 V and energy densities of 76.98 and 35.74 W h kg-1 when the power densities are 775.0 and 15 500 W kg-1, respectively, superior to most of the related materials reported. Through MAED, the deposited phase and the layer number can be accurately controlled, thus providing an efficient strategy for interface construction so as to increase the electrochemical activity of the energy storage materials.
RESUMEN
The controlled self-assembly of nanomaterials has been a great challenge in nanosynthesis, especially for hierarchical architectures with high complexity. Particularly, the structural design of Prussian blue (PB) series materials with robustness and fast nucleation is even more difficult. Herein, a self-sustained-release strategy based on the slow release of metal ions from coordination ions is proposed to guide the assembly of PB crystals. The key to this strategy is the slow release by ligand, which can create ultra-low concentrations of metal ions so as to provide the possibility to realize the surface charge manipulation of PB primary colloids. By adding electrolyte or changing the polarity of the solution, the surface charge regulation of PB colloid is realized, and the PB hierarchical structures with branch fractal structure (PB-BS), octahedral fractal structure, and spherical fractal structure are effectively constructed. This work not only achieves the designability of the PB structure, but also synchronizes the functionalization during the PB assembly growth process by in situ encapsulation of the effective catalytic active component L-Ascorbic acid. As a result, the assembled PB-BS exhibits greatly enhanced catalytic activity and selectivity in styrene oxidation with the selectivity of oxidized styrene increasing from 35.6% (PB) to 80.5% (PB-BS).
RESUMEN
The synthesis of high-entropy phosphide (HEP) remains a great challenge owing to the different migration rates of different metallic atoms. Herein, a new metal organic gel (MOG) precursor strategy is proposed for HEP synthesis by controlling the migration rate of different atoms in an organic gel. The MOG precursor with five kinds of metal and phosphor species homogeneously dispersing is formed through a facile solvothermal method, which is calcined at 900 °C to obtain carbon-supported HEP FeCoNiMnCdP (MPC-5). The difference in the atom radius and the influence of MOG on the migration rate result in heterogeneous aggregation of different atoms in the product, which increases the defects in the product to a certain extent. In addition, the presence of carbon and nitrogen in the gel simultaneously realizes carbon coating and nitrogen doping. Combining the above advantages, the MPC-5 shows excellent oxygen evolution reaction (OER) catalytic performance with an overpotential of 250 mV at 10 mA·cm-2, superior to many recently reported OER electrocatalysts. This work provides a new strategy to solve the differences in the migration rates of different metals to obtain pure phase high-entropy phosphides, which is conducive to the further development of high-entropy materials and their applications in the energy and catalysis fields.
RESUMEN
Due to the severe toxicity of triethylamine (TEA), the preparation of chemsensors with high sensitivity, low cost and visualization for TEA detection has been a research hotspot. However, based on the fluorescence turn-on detection of TEA remains rare. In this work, three two-dimensional conjugated polymers (2D CPs) were prepared by chemical oxidation polymerization. These sensors show a quick response and excellent selectivity toward TEA at room temperature. The minimum limit of detection (LOD) for TEA was 3.6 nM in the range of 10 µM â¼ 30 µM. Interestingly, the paper sensor based on P2-HCl can quantitatively detect TEA gas within 20 s, which showed great application potential in fields of environmental monitoring. Besides, Fourier transform infrared spectra (FT-IR), scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS) data were used to thoroughly interpret the sensing mechanism. This work provided an effective method for the development of 2D fluorescent chemosensors for TEA detection.
RESUMEN
The reversible transformation of a nanohelix is one of the most exquisite and important phenomena in nature. However, nanomaterials usually fail to twist into helical crystals. Considering the irreversibility of the previously studied twisting forces, the reverse process (untwisting) is more difficult to achieve, let alone the retwisting of the untwisted crystalline nanohelices. Herein, we report a new reciprocal effect between molecular geometry and crystal structure which triggers a twisting-untwisting-retwisting cycle for tri-cobalt salicylate hydroxide hexahydrate. The twisting force stems from competition between the condensation reaction and stacking process, different from the previously reported twisting mechanisms. The resulting distinct nanohelices give rise to unusual structure elasticity, as reflected in the reversible change of crystal lattice parameters and the mutual transformation between the nanowires and nanohelices. This study proposes a fresh concept for designing reversible processes and brings a new perspective in crystallography.
RESUMEN
Cell morphology is a fundamental feature used to evaluate patient specimens in pathologic analysis. However, traditional cytopathology analysis of patient effusion samples is limited by low tumor cell abundance coupled with the high background of nonmalignant cells, restricting the ability of downstream molecular and functional analyses to identify actionable therapeutic targets. We applied the Deepcell platform that combines microfluidic sorting, brightfield imaging, and real-time deep learning interpretations based on multidimensional morphology to enrich carcinoma cells from malignant effusions without cell staining or labels. Carcinoma cell enrichment was validated with whole genome sequencing and targeted mutation analysis, which showed a higher sensitivity for detection of tumor fractions and critical somatic variant mutations that were initially at low levels or undetectable in presort patient samples. Our study demonstrates the feasibility and added value of supplementing traditional morphology-based cytology with deep learning, multidimensional morphology analysis, and microfluidic sorting.
Asunto(s)
Líquidos Corporales , Carcinoma , Derrame Pleural Maligno , Humanos , Inteligencia Artificial , Derrame Pleural Maligno/diagnóstico , Derrame Pleural Maligno/patologíaRESUMEN
As we know, excessive metal ions can even damage human health. Herein, two novel kinds of fluorescent sensing materials Poly(3-amino-carbazole) derivatives containing 1,10-phenanthroline and 8-hydroxyquinoline were synthesized and further applied to fluorescence detection for ions. The results show that Ni2+, Cu2+, and Pd2+ have excellent quenching effects on the fluorescence of Poly[9-(1,10-phenanthroline-2-yl)-9H-carbazol-3-amine] (PPNC), the LOD for these ions reaches 5.2 nM, 12.7 nM, 33.5 nM respectively. In the process of ion response, there is no shift of UV absorption peak, combined with IR spectra and theoretical calculation simulation, the quenching is considered to be caused by the coordination between metal ions and the second amine (-NH-) or 1,10-phenanthroline ligand of PPNC, which leads to the charge transfer from ligands to metal ions. In addition, an acid test was done for PPNC to verify and detect the presence of secondary amine (-NH-), and the results show that PPNC has good acid sensing ability which also supports the secondary amine (-NH-) structure. Finally, the paper test was performed on PPNC, indicating that PPNC has the potential for visual application.
RESUMEN
High-entropy materials (HEMs) exhibit extensive application potential owing to their unique structural characteristics. Structure regulation is an effective strategy for enhancing material performance. However, the fabrication of HEMs by integrating five metal elements into a single crystalline phase remains a grand challenge, not to mention their structure regulation. Herein, an amorphous-to-crystalline transformation route is proposed to simultaneously achieve the synthesis and structure regulation of high-entropy metal oxides (HEMOs). Through a facile hydrothermal technique, five metal sources are uniformly integrated into amorphous carbon spheres, which are transformed to crystalline HEMOs after calcination. Importantly, by controlling ion diffusion and oxidation rates, HEMOs with different structures can be controllably achieved. As an example, HEMO of the five first-row transition metals CrMnFeCoNiO is synthesized through the amorphous-to-crystalline transformation route, and structure regulation from solid spheres to core-shell spheres, and then to hollow spheres, is successfully realized. Among the structures, the core-shell CrMnFeCoNiO exhibits enhanced lithium storage performance due to the component and structural advantages. Our work expands the synthesis methods for HEMs and provides a rational route for structure regulation, which brings them great potential as high-performance materials in energy storage and conversion.
RESUMEN
AIMS: Grape seed procyanidin extract (GSE), and milk thistle silymarin extract (MTE) contain structurally distinct polyphenols, and each agent has been shown to exert antineoplastic effects against lung cancer. We hypothesize that combinations of GSE and MTE will additively enhance their anticancer effects against lung cancer. MATERIALS AND METHODS: The anti-proliferative effects of GSE, MTE and combinations were evaluated in lung neoplastic cell lines. A dose range finding (DRF) study to determine safety, bioavailability and bioactivity, followed by human lung cancer xenograft efficacy studies were conducted in female nude mice with once daily gavage of leucoselect phytosome (LP), a standardized GSE, and/or siliphos, a standardized MTE. The roles of tumor suppressors miR-663a and its predicted target FHIT in mediating the additive, anti-proliferative effecs of GSE/MTE were also assessed. KEY FINDINGS: GSE with MTE additively inhibited lung preneoplastic and cancer cell proliferations. Mice tolerated all dosing regimens in the DRF study without signs of clinical toxicity nor histologic abnormalities in the lungs, livers and kidneys. Eight weeks of LP and siliphos additively inhibited lung tumor xenograft growth. Plasma GSE/metabolites and MTE/metabolites showed that the combinations did not decrease systemic bioavailabilities of each agent. GSE and MTE additively upregulated miR-663a and FHIT in lung cancer cell lines; transfection of antisense-miR-663a significantly abrogated the anti-proliferative effects of GSE/MTE, upregulation of FHIT mRNA and protein. LP and siliphos also additively increased miR-663a and FHIT protein in lung tumor xenografts. SIGNIFICANCE: Our findings support clinical translations of combinations of GSE and MTE against lung cancer.
Asunto(s)
Extracto de Semillas de Uva , Neoplasias Pulmonares , MicroARNs , Proantocianidinas , Silimarina , Vitis , Humanos , Femenino , Animales , Ratones , Proantocianidinas/farmacología , Vitis/metabolismo , Silybum marianum , Ratones Desnudos , Extracto de Semillas de Uva/farmacología , Neoplasias Pulmonares/patología , MicroARNs/metabolismoRESUMEN
It is a substantial challenge to construct electrocatalysts with high activity, good selectivity, and long-term stability for electrocatalytic reduction of carbon dioxide to formic acid. Herein, bismuth and indium species are innovatively integrated into a uniform heterogeneous spherical structure by a neoteric quasi-microemulsion method, and a novel C@In2 O3 @Bi50 core-shell structure is constructed through a subsequent one-step phase separation strategy due to melting point difference and Kirkendall effect with the nano-limiting effect of the carbon structure. This core-shell C@In2 O3 @Bi50 catalyst can selectively reduce CO2 to formate with high selectivity (≈90% faradaic efficiency), large partial current density (24.53 mA cm-2 at -1.36 V), and long-term stability (up to 14.5 h), superior to most of the Bi-based catalysts. The hybrid Bi/In2 O3 interfaces of core-shell C@In2 O3 @Bi will stabilize the key intermediate HCOO* and suppress CO poisoning, benefiting the CO2 RR selectivity and stability, while the internal cavity of core-shell structure will improve the reaction kinetics because of the large specific surface area and the enhancement of ion shuttle and electron transfer. Furthermore, the nano-limited domain effect of outmost carbon prevent active components from oxidation and agglomeration, helpful for stabilizing the catalyst. This work offers valuable insights into core-shell structure engineering to promote practical CO2 conversion technology.
RESUMEN
Defects, such as unsaturated coordination centers and vacancies, can fundamentally change materials' inherent properties and growth habits. The development of defect engineering has promoted the application of many technologies, but it is still a great challenge to selectively manufacture defect sites in existing material systems. It is shown here that in situ site-directed tailoring of metal sites in Prussian blue analogs (PBA) can be achieved according to the reducibility differences of different metal atoms, forming naturally nonpreferred unsaturated coordination centers. Meanwhile, the in situ capture of small reducing molecule can realize site-directed tailoring of crystal facets during crystal growth and results in oriented 1D growth. As an oxygen evolution reaction catalyst, the resulted PBA with the nonpreferred unsaturated coordination centers shows a low overpotential of 239 mV at 10 mA cm-2 in alkali, superior to the original PBAs and the previously reported defective PBA derivatives, which can be ascribed to the unsaturated coordination active center and the unique 1D structure. This work opens up opportunities for producing naturally nonpreferred unsaturated coordination center in nanomaterials for broad applications.
RESUMEN
According to the assumption that the formation of C-Pd bond becomes a cyclopalladated complex (CPC), we designed and synthesized two C-N-N pincer ligands of BODIPY appended 2,2'-bipyridine derivatives (BP and BPB). It has been confirmed that the C-Pd bond does exist and plays a crucial role in "on-off" fluorescence behavior. Based on it, a coordination-induced fluorescence quenching sensor for Pd2+ was constructed. The results indicated that BP possessed high sensitivity and specificity for Pd2+ in solution. The limit of detection (LOD) of BP is determined to be 0.97 nM within a linear range between 1.0 and 50.0 nM, meanwhile, the platinum-group ions demonstrate no interference. The bio-imaging application of BP was investigated and it exhibited a promising vitro test for fluorescent imaging of Pd2+ ions in MCF-7 cells. Meanwhile, BPB coated sensor label for Pd2+ was set up. The visible color variation was displayed under UV light with increasing concentrations of Pd2+. Briefly speaking, fluorescence probes of BP and BPB offer new approaches for Pd2+ detection in a lab and on-site test, as well as the vivo imaging. Then, with the aid of (TD)DFT calculation, the internal reason for the optical difference between the two ligands was disclosed. This concept of CPC containing a Pd-C covalent bond provides a promising perspective of coordination fluorescence sensors.
Asunto(s)
Paladio , Fluorescencia , Paladio/químicaRESUMEN
Rheumatoid arthritis (RA) is an autoimmune disease whose hallmarks are synovial inflammation and irreversible bone destruction. Bone resorption resulting from osteoclasts involves the whole immune and bone systems. Breakdown of bone remodeling is attributed to overactive immune cells that produce large quantities of cytokines, upregulated differentiation of osteoclasts with enhanced resorptive activities, suppressed differentiation of osteoblasts, invading fibroblasts and microbiota dysbiosis. Despite the mitigation of inflammation, the existing treatment in Western medicine fails to prevent bone loss during disease progression. Traditional Chinese medicine (TCM) has been used for thousands of years in RA treatment, showing great efficacy in bone preservation. The complex components from the decoctions and prescriptions exhibit various pharmacological activities. This review summarizes the research progress that has been made in terms of the bone-protective effect of some representative compounds from TCM drugs and proposes the substantial mechanisms involved in bone metabolism to provide some clues for future studies. These active components systemically suppress bone destruction via inhibiting joint inflammation, osteoclast differentiation, and fibroblast proliferation. Neutrophil, gut microenvironment and microRNA has been proposed as future focus.
RESUMEN
Modifying the separator of lithium-sulfur batteries (LSBs) is considered to be one of the most effective strategies for relieving the notorious polysulfide shuttle effect. Constructing a stable, lightweight, and effective LSB separator is still a big challenge but highly desirable. Herein, a stable and lightweight imide-based covalent organic framework (COF-TpPa) is facilely fabricated on reduced graphene oxide (rGO) through an oxygen-free solvothermal technique. With the directing effect of rGO and changing the side functional group of the monomer, the morphology and the pore tailoring of COF-TpPa can be simultaneously achieved and two-dimensional (2D) COF nanosheets with different functionalities (such as -SO3H and -Cl) are successfully constructed on rGO films. The specific functional groups inside the COF's pore channels and the narrowed pore size result in efficient absorption and restriction of Li2Sn for weakening the "shuttle effect". Meanwhile, the 2D COF nanosheets on the rGO is a favorable morphology for better exploiting pores inside the COF materials. As a result, the COF-SO3H-modified separator, consisting of rGO and COF-TpPa-SO3H, exhibits a high specific capacity (1163.4 mA h/g at 0.2 C) and a desirable cyclic performance (60.2% retention rate after 1000 cycles at 2.0 C) for LSBs. Our study provides a feasible strategy to rationally design functional COFs and boosts their applications in various energy storage systems.
RESUMEN
The design and synthesis of hollow-nanostructured transition metal oxide-based anodes is of great importance for long-term operation of lithium ion batteries (LIBs). Herein, a special hollow bowl-like α-Fe2O3 nanostructure is controllably synthesized through a facile hydrothermal technique and exhibits great electrochemical lithium storage performance when used as LIBs anode. Under a facile hydrothermal condition, α-Fe2O3 nanostructures evolve from solid pie-like structure to hollow bowl-like structure and finally α-Fe2O3 nanorings through the regulation of HPO4- derived from ionized Na3PO4·12H2O and Ostwald ripening process. The designed hollow bowl-like α-Fe2O3 nanostructure not only has the merits of hollow structure, which can accelerate the diffusion of lithium ions and electrons, but also shows great mechanical strength to disperse stress when compared to solid pie-like and ring-like α-Fe2O3 nanostructures, which would avoid collapse during charge/discharge process. As a result, the as-synthesized hollow bowl-like α-Fe2O3 nanostructure displays an initial reversible capacity of 1616 mAh g-1 at a current density of 1 A g-1, an excellent cycling performance with a reversible capacity of 1018 mAh g-1 after 500 cycles and an outstanding rate capability (68.1% capacity retention at current densities from 100 to 2000 mA g-1). This work provides not only a novel hollow bowl-like α-Fe2O3 nanostructure with high specific surface area and stable structure as potential electrode materials for energy storage, but also a facile self-templated strategy free of any surfactants and templates for hollow nanostructures.
RESUMEN
Rheumatoid arthritis (RA) is a common autoimmune disease worldwide. Neutrophils play critical roles in the onset and development of RA and are the promising target for RA treatment. Tetrandrine is a bis-benzyl isoquinoline alkaloid derived from the traditional Chinese herbal Stephania tetrandra S. Moore. Tetrandrine is effective in alleviating RA by inhibiting macrophage inflammatory response, fibroblast overproliferation, and pannus formation. However, whether tetrandrine regulates the activities of neutrophils in RA is largely unknown. In this study, we adopted adjuvant-induced arthritis (AA) murine model to explore the effect of tetrandrine on RA and neutrophils. Twenty-eight mice were divided into four groups. The control group was injected with PBS in the limbs and treated with PBS by intraperitoneal injection (i.p.) from Day 10 to Day 37. The arthritis murine model was induced by injecting FCA into the ankle joints of hind limbs. The AA group, the AA + TET group, and the AA + DEX group mice were treated with PBS, tetrandrine (6 mg/kg), or dexamethasone (1 mg/kg) i.p. daily, respectively. Arthritic scores were evaluated, and the joint diameter was measured every three days. A cytometric bead assay was performed to measure the concentrations of IFN-γ, TNF-α, and IL-6 in the serum. H&E staining and Safranin O-fast staining were adopted to monitor the tissue changes in the joint. Immunohistochemistry assays were applied to detect the MPO, NE, CitH3, and PAD4 expression levels. To assess the effect of tetrandrine on neutrophil activities in vitro, CCK8 tests were applied to determine cell viability. The qPCR and ELISA were performed to determine IL-1ß and IL-6 expression levels. Immunofluorescence assays were performed to measure the formation of NETs. The results indicated that tetrandrine significantly alleviated the symptoms of RA in terms of the ankle diameter (from 4.629 ± 2.729 to 3.957 ± 0.257; P < 0.01) and ankle score (from 4.000 ± 0.000 to 3.286 ± 0.756; P < 0.05). Tetrandrine treatment significantly increased the cartilage areas and decreased serum IL-6 significantly (from 5.954 ± 2.127 to 2.882 ± 2.013; P < 0.01). The immunohistochemistry assays also showed decreased expression levels of NE, MPO, PAD4, and CitH3 induced by tetrandrine in comparison with the AA group (P < 0.01). The qPCR assays and ELISAs showed that tetrandrine had an anti-inflammatory effect in vitro by significantly inhibiting IL-6 (P < 0.01). The immunofluorescence assays showed that NET formation induced by PMA could be reduced by tetrandrine (P < 0.01). In conclusion, tetrandrine has good efficacy in treating RA by regulating neutrophil-involved inflammation and NET formation.
RESUMEN
Three-dimensional (3D) network structure of metal-organic framework (MOF) can accommodate outstanding electrocatalysis performances, but always collapse during the conversion to active materials or applications process. How to maintain the 3D network when producing active species is of great importance for full application of MOF. Herein, a new MOF material, In[Co(CN)6] (In-Co PBA) nanocubes, are firstly synthesized. Through a controlled low-temperature deligandation process, the In-Co PBA nanocubes are transformed to a novel In2O3@In-Co PBA quasi-MOF nanocubes, which basically retain the 3D porous structure of PBA but with in situ generated In2O3 nanoparticles inside. When used as CO2RR electrocatalyst, such a novel cubic composite structure exhibits excellent performances with faradaic efficiency of 85% for formate at a potential of -0.96 V and with current density of 31.5 mA·cm-2 at -1.32 V, surpassing most of the reported indium-based catalysts. The excellent performance can be attributed to the special composite structure, which provides not only active sites by In2O3 nanoparticles to catalyze CO2RR, but also the 3D porous framework by quasi-MOF to accelerate gaseous exchange and electrolyte permeation and prevent the electrode choking. This work offers a new strategy for the design of post-transition metal catalysts and the structure design of quasi-MOF.
RESUMEN
OBJECTIVES: Dietary factors are of importance in the development of stomach cancer. This study aims to examine index-based dietary patterns associated with stomach cancer in a Chinese population. METHODS: Using data from a population-based case-control study conducted in Jiangsu Province, China, we included a total of 8432 participants (1900 stomach cancer cases and 6532 controls). Dietary data collected by food frequency questionnaire was evaluated by modified Chinese Healthy Eating Index-2016 (mCHEI-2016) and the US Healthy Eating Index-2015 (HEI-2015). Multiple logistic regression analyses were applied to examine the association of mCHEI-2016 and HEI-2015 with stomach cancer while adjusting for potential confounders. The possible interactions between mCHEI-2016 or HEI-2015 and established risk factors were explored. RESULTS: Among nonproxy interviews, after adjusting for potential confounding factors, a higher score of sodium, reflecting lower intake per day, was inversely associated with stomach cancer [odds ratio (OR), 0.95; 95% CI, 0.91-0.99 for mCHEI-2016; OR, 0.97; 95% CI, 0.94-0.99 for HEI-2015]. No clear associations with stomach cancer were identified for total scores of HEI-2015 (OR, 0.98; 95% CI, 0.87-1.10 with a 10-point increase, P trend = 0.98) and mCHEI-2016 (OR, 1.05; 95% CI, 0.94-1.17 with a 10-point increase, P trend = 0.22). However, the relation between stomach cancer and the mCHEI-2016 was modified by BMI, with a possible inverse association in normal-weight subjects. CONCLUSIONS: Our findings highlight that reduced intake of dietary sodium would prevent the development of stomach cancer. The data indicate a heterogeneity between normal weight and overweight's dietary factors in relation to stomach cancer.
Asunto(s)
Neoplasias Gástricas , Estudios de Casos y Controles , Dieta/efectos adversos , Dieta Saludable , Humanos , Factores de Riesgo , Neoplasias Gástricas/epidemiología , Neoplasias Gástricas/etiología , Neoplasias Gástricas/prevención & controlRESUMEN
Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is known as a rare disease characterized by inflammatory lesions on bones and skin. Polymorphism of clinical manifestation and lack of molecular biomarkers have both limited its diagnosis. Our study performed RNA sequencing (RNA-seq) and integrative bioinformatics analysis of long noncoding RNA (lncRNA)-messenger RNA (mRNA) profile in patients with SAPHO syndrome and healthy controls. A total of 4,419 differentially expressed (DE) mRNAs and 2,713 lncRNAs were identified (p < 0.05, fold change > 2) and a coexpression network was constructed to further investigate their regulatory interactions. The DE lncRNAs were predicted to interact with mRNAs in both cis and trans manners. Functional prediction found that the lncRNA-targeted genes may function in SAPHO syndrome by participating in biological process such as adipocytokine signaling pathway, ErbB signaling pathway, FoxO signaling pathway, as well as production and function of miRNAs. The expression levels of three pairs of coexpressed lncRNA-mRNAs were validated by qRT-PCR, and their relative expression levels were consistent with the RNA-seq data. The deregulated RNAs GAS7 and lnc-CLLU1.1-1:2 may serve as potential diagnostic biomarkers, and the combined receiver operating characteristic (ROC) curve of the two showed more reliable diagnostic ability with an AUC value of 0.871 in distinguishing SAPHO patients from healthy controls. In conclusion, this study provides a first insight into long noncoding RNA transcriptome profile changes associated with SAPHO syndrome and inspiration for further investigation on clinical biomarkers and molecular regulators of this inadequately understood clinical entity.