1.
Steroids
; 41(1): 1-13, 1983 Jan.
Artículo
en Inglés
| MEDLINE
| ID: mdl-6658861
RESUMEN
Nine dioxygenated D-homoandrostanes were incubated with Rhizopus nigricans to investigate the effect of D-ring modification on microbiological hydroxylation. Structure determination of the products by NMR spectroscopy, and in certain cases independent synthesis of their oxidised products, showed that in contrast to 5 alpha-androstanes the majority of the compounds were hydroxylated in the "reverse" mode, and only D-homo-5 alpha-androstane-3,17-dione was hydroxylated in the "normal" mode to any extent. Stereospecific ring D-hydroxylation at C(17 alpha) was observed for both D-homo-5 alpha-androstane-3,6- and 3,7-diones.
Asunto(s)
Androstanos/metabolismo , Homoesteroides/metabolismo , Rhizopus/metabolismo , Espectroscopía de Resonancia Magnética , Conformación Molecular , Relación Estructura-Actividad
2.
J Org Chem
; 42(7): 1221-5, 1977 Apr 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-845707