1.
Org Biomol Chem
; 21(48): 9524-9529, 2023 Dec 13.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37997680
RESUMEN
An eco-friendly and metal-free method for the synthesis of tetrahydrodibenzo[b,g][1,8]naphthyridin-1(2H)-ones was established. Quinoline-derived dipolarophiles and cyclic enaminones as starting materials undergo a 1,4-Michael addition/SNAr tandem annulation reaction affording the target products. This approach features transition metal-free conditions, good functional group tolerance and operational simplicity.