[Study on the acryl amide intake in the Beijing diet].

OBJECTIVE: A 24-hours recall study was performed to get the acryl amide intake in the Beijing diet. METHODS: 24 separate items bought in the Beijing Market were analyzed and 2460 diet lists (820 participants x 3 days) were calculated. RESULTS: The following mean intakes of acryl amide have been estimated (microg/dm): males 18.6, females 16.6. For the 97.5 percentile of the population the intake is estimated to: males 59.0, females 50.4. As dose calculated per kg bodyweight the mean intake becomes [microg/(kg bw x d)]: males 0.282, females 0.284. For the 97.5 percentile [microg/ (kg bw x d)]: males 0.898, females 1.007. The contribution of the different meals and to the intake was as follows: breakfast 20.48%, lunch 38.99%, dinner 39.42%, snacks 1.17%. CONCLUSION: The survey leads to the conclusion that lunch and dinner are significant sources of acryl amide in a typical Beijing diet even if they have relatively low levels of acryl amide. Chinese traditional breakfast food is also an important source of acryl amide in a typical Beijing.

[Study on the absorption, distribution and excretion of 3-chloro-1,2-propandiol in rats].

OBJECTIVE: To explore the absorption, distribution and excretion of 3-Chloro-1,2-propandiol (3-MCPD) in healthy male SD rats after oral administration. METHODS: 3-MCPD was administrated with a single oral dosage of 75 mg/kg BW to each rat. Samples of blood, tissues (including liver, kidney, brain and testicle) and excreta were then collected, and analyzed by the GC-MS method to determine 3-MCPD concentrations. The reported value is the mean value of three rats. RESULTS: At 2 h after the administration, 3-MCPD concentrations in blood, testicle and kidney were (67.46 +/- 7.72), (78.37 +/- 5.15) and (56.21 +/- 3.64) microg/g, respectively. At 24 h, however, the corresponding values changed to (1.07 +/- 0.97) microg/g, (49.43 +/- 28.18) microg/g and (11.41 +/- 2.55) microg/g. During the 24-hour period, 9.74 +/- 3.05% of the given parent compound was excreted in urine, whereas 0.56 +/- 0.22% and 0.28 +/- 0.03% were excreted in feces and bile, respectively, which implies that kidney is a major organ for excretion 3-MCPD. CONCLUSIONS: 3-MCPD was quickly absorbed through the alimentary tract and quickly distributed into a number of tissues, and then accumulated in the target organs, especially in the testicle. The excretion of the parent compound was largely through the kidney. It was inferred that 3-MCPD was mainly metabolized in the liver.