Combined exercise on fatigue, quality of life and physical functioning in people under chemotherapy with oxaliplatin: Systematic review and meta-analysis.

OBJECTIVE: To investigate the effects of combined exercise on fatigue, anxiety, depression, quality of life and physical functioning in gastroinstestinal neoplasm in people under chemotherapy with oxaliplatin treatment. METHODS: We searched pubmed/MEDLINE, Cochrane Central Register of Controlled Trials, PEDro data base, and SciELO (until Nov 2023) for randomized controlled trials that investigated the effects of combined exercise in gastroinstestinal neoplasm people under chemotherapy with oxaliplatin treatment. Two comparisons were made: combined exercise versus usual care, combined aerobic and versus usual care (follow up). The main outcomes were muscle strength, aerobic capacity, fatigue, anxiety, depression and quality of life. Mean differences (MD) with 95% confidence interval (CI) were calculated. RESULTS: Seven randomized controlled trials met the eligibility criteria, which included 464 people. Compared to usual care, combined aerobic and resistance resulted in decrease of general fatigue (-2.82; IC: 4.92 to -0.69, N = 48), physical fatigue (-5.08; IC: 8.41 to -1.74, N = 48) and improvement of domain physical functioning of quality of life (9.40; IC: 2.74 to 16.06, N = 48). Compared to usual care, combined aerobic and resistance - Follow up resulted in decrease of general fatigue (-2.32; IC: 4.41 to - 0.28, N = 48), physical fatigue (-0.92; IC: 3.31 to -1.47, N = 48) and improvement ofdomain physical functioning of (9.83; IC: 0.66 to 19.01, N = 48). CONCLUSIONS: Our results demonstrate that combined exercises improves fatigue (general; physical), domain physical functioning of quality of life in gastrointestinal neoplasm people under chemotherapy treatment when compared to usual care.

Effects of water-based exercises on functioning of postmenopausal women: A systematic review with meta-analysis.

OBJECTIVE: The aim of the present study was to compare the efficacy of Water-Based Exercise (WBE) versus Land-Based Exercise (LBE) and of WBE versus Non-Exercise in postmenopausal women on muscle strength, agility, flexibility, bone mineral density and aerobic capacity. METHODS: We systematically searched in MEDLINE, PEDro, SciELO and the Cochrane Library RCT published until May 2022. Only randomized controlled trials were included. We analyzed the pooled results using weighted mean differences, standardized mean difference, and 95%CI were calculated. RESULTS: Twenty studies met the inclusion criteria; although, sixteen studies were included in the meta-analyses. The studies presented low methodological quality. WBE was more effective than NE for improving muscle strength of knee extension (3.34), knee flexion (2.51), arm curl (6.78 repetitions), VO2Max (4.12 ml/kg), and flexibility (6.38 cm) When comparing WBE with LBE, no significant statistical difference was found regarding muscular strength of lower limbs (1.00), muscular strength of upper limbs (0.47), flexibility (1.95 cm), aerobic capacity (0.82 ml/kg) and lumbar bone mineral density (0.04 g/cm2). CONCLUSIONS: WBE promotes significant benefits in muscle strength, aerobic capacity, and flexibility, when compared to no intervention. However, WBE was similar to the LBE for improving muscle strength, aerobic capacity, flexibility, agility, and bone mineral density - lumbar in postmenopausal women.

Electroencephalography Signatures for Conditioned Pain Modulation and Pain Perception in Nonspecific Chronic Low Back Pain-An Exploratory Study.

Conditioned pain modulation (CPM) can discriminate between healthy and chronic pain patients. However, its relationship with neurophysiological pain mechanisms is poorly understood. Brain oscillations measured by electroencephalography (EEG) might help gain insight into this complex relationship. OBJECTIVE: To investigate the relationship between CPM response and self-reported pain intensity in non-specific chronic low back pain (NSCLBP) and explore respective EEG signatures associated to these mechanisms. DESIGN: Cross-sectional analysis. PARTICIPANTS: Thirty NSCLBP patients participated. METHODS: Self-reported low back pain, questionnaires, mood scales, CPM (static and dynamic quantitative sensory tests), and resting surface EEG data were collected and analyzed. Linear regression models were used for statistical analysis. RESULTS: CPM was not significantly correlated with self-reported pain intensity scores. Relative power of EEG in the beta and high beta bands as recorded from the frontal, central, and parietal cortical areas were significantly associated with CPM. EEG relative power at delta and theta bands as recorded from the central area were significantly correlated with self-reported pain intensity scores while controlling for self-reported depression. CONCLUSIONS: Faster EEG frequencies recorded from pain perception areas may provide a signature of a potential cortical compensation caused by chronic pain states. Slower EEG frequencies may have a critical role in abnormal pain processing.