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J Cereb Blood Flow Metab ; 35(1): 131-9, 2015 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-25352043

RESUMEN

Quantitative oxygen extraction fraction (OEF) in cortical veins was studied in patients with multiple sclerosis (MS) and healthy subjects via magnetic resonance imaging (MRI) phase images at 7 Tesla (7 T). Flow-compensated, three-dimensional gradient-echo scans were acquired for absolute OEF quantification in 23 patients with MS and 14 age-matched controls. In patients, we collected T2*-weighted images for characterization of white matter, deep gray matter, and cortical lesions, and also assessed cognitive function. Variability of OEF across readers and scan sessions was evaluated in a subset of volunteers. OEF was averaged from 2 to 3 pial veins in the sensorimotor, parietal, and prefrontal cortical regions for each subject (total of ~10 vessels). We observed good reproducibility of mean OEF, with intraobserver coefficient of variation (COV)=2.1%, interobserver COV=5.2%, and scan-rescan COV=5.9%. Patients exhibited a 3.4% reduction in cortical OEF relative to controls (P=0.0025), which was not different across brain regions. Although oxygenation did not relate with measures of structural tissue damage, mean OEF correlated with a global measure of information processing speed. These findings suggest that cortical OEF from 7-T MRI phase is a reproducible metabolic biomarker that may be sensitive to different pathologic processes than structural MRI in patients with MS.


Asunto(s)
Encéfalo/metabolismo , Metabolismo Energético , Imagen por Resonancia Magnética , Esclerosis Múltiple/metabolismo , Esclerosis Múltiple/patología , Oxígeno/metabolismo , Adulto , Encéfalo/irrigación sanguínea , Encéfalo/patología , Estudios de Casos y Controles , Venas Cerebrales/metabolismo , Cognición/fisiología , Femenino , Humanos , Masculino , Esclerosis Múltiple/psicología , Pruebas Neuropsicológicas , Oxígeno/sangre , Estudios Prospectivos , Reproducibilidad de los Resultados
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