RESUMEN
We report these cases to emphasize the importance of recognizing fluoroscopy as a cause of radiation dermatitis. The diagnosis of fluoroscopy-induced chronic radiation dermatitis should be raised when patients present with morpheaform, telangiectatic, or ulcerative skin findings in the characteristic locations.
Asunto(s)
Fluoroscopía/efectos adversos , Radiodermatitis/etiología , Anciano , Enfermedad Crónica , Femenino , Humanos , Masculino , Persona de Mediana Edad , Radiodermatitis/patologíaAsunto(s)
Adenocarcinoma Mucinoso/patología , Neoplasias Faciales/patología , Neoplasias Cutáneas/patología , Adenocarcinoma Mucinoso/cirugía , Anciano de 80 o más Años , Biopsia con Aguja , Neoplasias Faciales/cirugía , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Masculino , Estadificación de Neoplasias , Neoplasias Cutáneas/cirugía , Trasplante de Piel/métodos , Resultado del TratamientoRESUMEN
Nocardia, Actinomyces, and Streptomyces species comprise the three broad classes of organisms that are causative for bacterial mycetoma. Although culture and molecular laboratory studies can usually identify the precise etiologic agent in bacterial mycetoma, occasionally these methods fail to clarify this situation. We report a classic clinical case of this infectious disease where usual diagnostic methods failed to identify the responsible organism, and discuss the empiric approach to such cases.
Asunto(s)
Micetoma/diagnóstico , Nocardia/aislamiento & purificación , Piel/microbiología , Antibacterianos/uso terapéutico , Emigrantes e Inmigrantes , Reacciones Falso Negativas , Antebrazo/microbiología , Antebrazo/patología , Humanos , Masculino , Técnicas Microbiológicas , Persona de Mediana Edad , Micetoma/tratamiento farmacológico , Micetoma/microbiología , Piel/patología , Combinación Trimetoprim y Sulfametoxazol/uso terapéuticoRESUMEN
Few papers discuss the potential challenge of differentiating dermatophytosis from subacute cutaneous lupus erythematosus. This masquerade, most often manifest on the face, is of both clinical and therapeutic importance. We report a patient whose extensive tinea corporis very closely mimicked SCLE. The threshold for biopsy should be low in cases that exhibit atypical features for either of these entities.
Asunto(s)
Lupus Eritematoso Cutáneo/diagnóstico , Piel/patología , Tiña/diagnóstico , Arthrodermataceae/aislamiento & purificación , Diagnóstico Diferencial , Femenino , Humanos , Persona de Mediana Edad , Cuello/microbiología , Cuello/patología , Piel/microbiología , Tórax/microbiología , Tórax/patologíaRESUMEN
BACKGROUND: Interferon-gamma acts to multiply the potency with which innate interferons (alpha/beta) suppress herpes simplex virus type 1 (HSV-1) replication. Recent evidence suggests that this interaction is functionally relevant in host defense against HSV-1. However, it is not clear which WBCs of the innate immune system, if any, limit HSV-1 spread in an IFN-gamma dependent manner. The current study was initiated to determine if natural killer (NK) cells provide innate resistance to HSV-1 infection, and if so to determine if this resistance is IFN-gamma-dependent. RESULTS: Lymphocyte-deficient scid or rag2(-/-) mice were used to test four predictions of the central hypothesis, and thus determine if innate resistance to HSV-1 is dependent on 1. NK cell cytotoxicity, 2. NK cells, 3. WBCs, or 4. the IFN-activated transcription factor, Stat 1. Loss of NK cell cytotoxic function or depletion of NK cells had no effect on the progression of HSV-1 infection in scid mice. In contrast, viral spread and pathogenesis developed much more rapidly in scid mice depleted of WBCs. Likewise, loss of Stat 1 function profoundly impaired the innate resistance of rag2(-/-) mice to HSV-1. CONCLUSION: Lymphocyte-deficient mice possess a very tangible innate resistance to HSV-1 infection, but this resistance is not dependent upon NK cells.
Asunto(s)
Herpes Simple/inmunología , Herpesvirus Humano 1/inmunología , Inmunidad Innata , Linfocitos/inmunología , Animales , Proteínas de Unión al ADN/deficiencia , Femenino , Interferón gamma/inmunología , Ratones , Ratones Endogámicos BALB C , Ratones Noqueados , Ratones SCIDRESUMEN
Thalidomide has gained an infamous history due to severe birth defects observed in patients who had taken the drug to control nausea during pregnancy. The medication was withdrawn from the market because of its teratogenicity, but was approved by the FDA in 1998 for the treatment of erythema nodosum leprosum. However, thalidomide has been employed with success by dermatologists for a host of off-label uses including the treatment of lichen planus. Currently, no clinical trials or studies exist to evaluate the efficacy of using thalidomide to treat lichen planus, but case reports have been published in the medical literature supporting its therapeutic benefits. TNF-alpha is among the many cytokines that have been implicated in the pathogenicity of lichen planus. It is thought that thalidomide acts.
Asunto(s)
Inmunosupresores/uso terapéutico , Liquen Plano/tratamiento farmacológico , Talidomida/uso terapéutico , Adulto , Complicaciones de la Diabetes/tratamiento farmacológico , Femenino , Hepatitis C/complicaciones , Humanos , Liquen Plano/patología , Piel/patologíaRESUMEN
Rickettsial and ehrlichial infections are both carried by arthropod vectors. Both Rickettsia and Ehrlichia are small intracellular gram-negative coccobacilli. Clinical manifestations of Rickettsia range from spotted fevers to various forms of typhus. Human ehrlichiosis can present as monocytic ehrlichiosis or granulocytic anaplasmosis. Prevention is by avoidance of the responsible vectors. Therapy is usually with doxycycline, but chloramphenicol can also be used.
