Assorted optical solitons of the (1+1)- and (2+1)-dimensional Chiral nonlinear Schrödinger equations using modified extended tanh-function technique.

In this research article, the (1+1)- and (2+1)-dimensional Chiral nonlinear Schrödinger equations (CNLSEs) are studied, which play an important role in the development of quantum mechanics, particularly in the field of quantum Hall effect. Our primary goal is to obtain the analytical solutions utilizing novel methodology, particularly the modified extended tanh-function technique. We concentrate on the search to solitary wave solutions inside the (1+1)- and (2+1)-dimensional CNLSEs, which are relevant in domains such as optics, electro-magnetic wave propagation, plasma physics, optics and quantum mechanics. Our objective is to increase knowledge of this equation and give insight into the behavior of solitary waves by employing a novel mathematical technique. This will be accomplished by displaying our findings in 2D and 3D graphics. We believe that our results would pave a way for future research generating optical memories based on the nonlinear solitons.

Multiple rogue wave, double-periodic soliton and breather wave solutions for a generalized breaking soliton system in (3 + 1)-dimensions.

We focused on solitonic phenomena in wave propagation which was extracted from a generalized breaking soliton system in (3 + 1)-dimensions. The model describes the interaction phenomena between Riemann wave and long wave via two space variable in nonlinear media. Abundant double-periodic soliton, breather wave and the multiple rogue wave solutions to a generalized breaking soliton system by the Hirota bilinear form and a mixture of exponentials and trigonometric functions are presented. Periodic-soliton, breather wave and periodic are studied with the usage of symbolic computation. In addition, the symbolic computation and the applied methods for governing model are investigated. Through three-dimensional graph, density graph, and two-dimensional design using Maple, the physical features of double-periodic soliton and breather wave solutions are explained all right. The findings demonstrate the investigated model's broad variety of explicit solutions. All outcomes in this work are necessary to understand the physical meaning and behavior of the explored results and shed light on the significance of the investigation of several nonlinear wave phenomena in sciences and engineering.

Interactions among lump optical solitons for coupled nonlinear Schrödinger equation with variable coefficient via bilinear method.

In this paper, a non-autonomous (3+1) dimensional coupled nonlinear Schrödinger equation (NLSE) with variable coefficients in optical fiber communication is analyzed. By means of bilinear technique and symbolic computations, new multi-soliton solutions of the coupled model in different trigonometric and lump functions are given. Then, in terms of perturbed waves, considering the steady state solution and the small perturbation on the three directions x, y, z and the time t, the soliton transmission are also considered. The behaviour of interaction among lump periodic soliton is studied and optical soliton solutions are reached. This study has certain significance for the analysis of other nonlinear dispersion systems and the application of optical physics. The results are presented through graphs generated by using Maple. The important feature of the proposed study is to show different behaviour of the soliton at each component. The behaviour of solitons, their interactions, and their transformations are all governed by the fundamental concept of energy conservation in all three examples. We demonstrate the efficiency of our suggested methodology for analyzing the NLSE equations using the numerical simulations and analytical tools, yielding fresh insights into their behaviour and solutions. Our findings help to develop mathematical tools for investigating nonlinear partial differential equation (NLPDEs) and provide new insights on the dynamics of NLSE equations, which have implications for many domains of physics and applied mathematics.

Effect of prosthetic management of congenital cleft lip and palate on the middle ear function of infants: A clinical trial.

STATEMENT OF PROBLEM: Infants with a cleft palate often experience middle ear disease, a condition of great significance, and early prosthetic management of these infants is essential. However, any correlation between prosthetic palatal obturation and middle ear function is unclear. PURPOSE: The purpose of this clinical trial was to assess whether prosthetic palatal obturation with a feeding appliance prevented or improved middle ear problems in infants with a cleft lip and palate. MATERIAL AND METHODS: Ten infants with congenital cleft lip and palate (20 ears) were referred to the Prosthodontics department immediately after birth. Assessment of the middle ear function by tympanometry as well as hearing quality by auditory brainstem response (ABR) was conducted before the prosthetic treatment (control readings). The middle ear function and hearing quality was followed up after the prosthetic treatment every month until surgical palatal closure (tenth month). The Friedman test was applied to compare data from the various study periods. When the results were significant, the Dunn post hoc test was conducted to compare the control first week readings with those of the later periods (α=.05 for all tests). RESULTS: The preprosthetic readings of tympanometry in the first week were 90% Type A and 10% Type B for both right and left ears. Readings starting from the first to the fifth month revealed no statistically significant differences compared with the first week readings (P>.05). However, tympanometry readings starting from the sixth month (20% Type A and 80% Type B) until the tenth month (90% Type B and 10% Type C) for both ears represented a statistically significant difference compared with the first week readings (P≤.05). The preprosthetic readings of ABR in the first week showed that 90% of ears had normal hearing status and 10% had mild hearing loss. Readings starting from the first until the fifth month revealed no statistically significant differences compared with the first week readings (P>.05). However, ABR readings starting from the sixth month (20% normal hearing, 70% mild hearing loss, and 10% moderate hearing loss) until the tenth month (0% normal hearing, 80% mild hearing loss, and 20% moderate hearing loss) for both ears revealed a statistically significant difference compared with the first week readings (P≤.05). CONCLUSIONS: Prosthetic palatal obturation with a feeding appliance plays a role in delaying rather than preventing the occurrence of otitis media with effusion in infants with a cleft lip and palate and could reduce the need for ventilation tubes.

Identification of NEK7 inhibitors: structure based virtual screening, molecular docking, density functional theory calculations and molecular dynamics simulations.

NEK7 is a NIMA related-protein kinase that plays a crucial role in spindle assembly and cell division. Dysregulation of NEK7 protein leads to development and progression of different types of malignancies including colon and breast cancers. Therefore, NEK7 could be considered as an attractive target for anti-cancer drug discovery. However, few efforts have been made for the development of selective inhibitors of NIMA-related kinase but still no FDA approved drug is known to selectively inhibit the NEK7 protein. Dacomitinib and Neratinib are two Enamide derivatives that were approved for treatment against non-small cell lung cancer and breast cancer respectively. Drug repurposing is a time and cost-efficient method for re-evaluating the activities of previously authorized medications. Thus, the present research involves the repurposing of two FDA-approved medications via comprehensive in silico approach including Density functional theory (DFTs) studies which were conducted to determine the electronic properties of the Dacomitinib and Neratinib. Afterward, binding orientation of selected drugs inside NEK7 activation loop was evaluated through molecular docking approach. Selected drugs exhibited potential molecular interactions engaging important amino acid residues of active site. The docking score of Dacomitinib and Neratinib was -30.77 and -26.78 kJ/mol, respectively. The top ranked pose obtained from molecular docking was subjected to Molecular Dynamics (MD) Simulations for investigating the stability of protein-ligand complex. The RMSD pattern revealed the stability of protein-ligand complex throughout simulated trajectory. In conclusion, both drugs displayed inhibitory efficacy against NEK7 protein and provide a prospective therapy option for malignant malignancies linked with NEK7.

Expanding the Phenotypic Spectrum of APMR4 Syndrome Caused by a Novel Variant in LSS Gene and Review of Literature.

Alopecia intellectual disability syndromes 4 (APMR4) is a very rare autosomal recessive condition caused by a mutation in the LSS gene present on chromosome 21. This syndrome has a clinical heterogeneity mainly exhibited with variable degrees of intellectual disability (ID) and congenital alopecia, as well. Eight families with 13 cases have been previously reported. Herein, we provide a report on an Egyptian family with two affected siblings and one affected fetus who was diagnosed prenatally. Whole-exome sequencing (WES) revealed a novel pathogenic missense variant (c.1609G > T; p.Val537Leu) in the lanosterol synthase gene (LSS) related to the examined patients. The detected variant was confirmed by Sanger sequencing. Segregation analyses confirmed that the parents were heterozygous. Our patient was presented with typical clinical manifestations of the disease in addition to new phenotypic features which included some dysmorphic facies as frontal bossing and bilateral large ears, as well as bilateral hyperextensibility of the fingers and wrist joints, short stature, umbilical hernia, and teeth mineralization defect. This study is the first study in Egypt and the 9th molecularly proven family to date. The aim is to expand the clinical and mutational spectrum of the syndrome. Moreover, the report gives a hint on the importance of prenatal testing and the proper genetic counseling to help the parents to take their own decision based on their beliefs.

Thermal radiation effect on unsteady mixed convection boundary layer flow and heat transfer of nanofluid over permeable stretching surface through porous medium in the presence of heat generation.

Here, we study the effect of mixed convection and thermal radiation on unsteady boundary layer of heat transfer and nanofluid flow over permeable moving surface through a porous medium. The effect of heat generation is also discussed. The equations governing the system are the continuity equation, momentum equation and the heat transfer equation. These governing equations transformed into a system of nondimensional equations contain many physical parameters that describe the study. The transformed equations are solved numerically using an implicit finite difference technique with Newton's linearization method. The thermo-physical parameters describe the study are the mixed convection parameter α, 0≪α≪10, the Radiation parameter Rd, 0≪Rd≪1.0, porous medium parameter k, 0≪k≪1.0, the nanoparticles volume ϕ,0≪≪0.2, the suction or injection parameter fw, -1≪fw≪1, the unsteadiness parameter At, 1≪At≪2 and the heat source parameter λ = 0.5 .The influence of the thermo-physical parameters is obtained analytically and displayed graphically. Comparisons of some special cases of the present study are performed with previously published studies and a good agreement is obtained.

Optical study of a static benzoxazinone derivative doped poly (vinyl) pyrrolidone - Poly(vinyl) alcohol blend system.

Blends with composition 50/50(wt/wt%)poly(vinyl)alcohol (PVA)/poly(vinyl) pyrrolidone (PVP) doped with different weight ratios from benzoxazinone derivative (BZ) were prepared by casting solution technique. The optical absorption was recorded at room temperature in the wavelength range of 190-1100nm. Tauc's plots revealed direct allowed transition with optical band gap, Eopt, of 5.20eV for blend film. Under addition of benzoxazinone, the optical energy value decreased until 2.60eV for 12wt% BZ blend system. Optical parameters such as refractive index, dielectric constant, dielectric loss and color constants were determined. Benzoxazinone molecules have a significant effect on optical parameters.

Optical properties of polyvinyl alcohol film irradiated with Nd:YAG laser.

Casting solution method has been used to prepare Polyvinyl alcohol (PVA) film. The prepared film has been irradiated with a laser beam of 6ns Q-switched Nd:YAG laser (Lotus II) operating at 10Hz and fourth harmonic wavelength, 266nm, at different irradiation times. Optical absorbance of the irradiated sample was studied in the wavelength region between 200 and 800nm. The absorption peak shift of 272nm towards the longer wavelengths region and the increase of absorption as the irradiation time increases, are related to the increase in crosslinking network. The fitting technique of the absorbance revealed an indirect allowed transition with optical energy gap of 4.22eV for the pristine PVA sample, and 2.85eV after 2h of laser irradiation. The index of refraction and the dielectric function showed dispersion in the studied wavelength range. The analysis of color parameters of PVA showed an observable change after laser irradiation.

Optical properties of hydroxyethyl cellulose film treated with nitrogen plasma.

Hydroxyethyl cellulose (HEC) film has been prepared by casting technique. The prepared sample has been treated with nitrogen plasma at different exposure times. The optical absorption was recorded at room temperature in the wavelength range of 200-800 nm. Absorbance fitting procedure curves revealed a direct allowed transition with optical band gap, Eopt, of 4.9 eV for pristine film, and this value decreases to 4.30 eV for 20 min plasma treatment time. The band tail values (Ee) were found to be increased under plasma time treatment from 1.74 eV in case of the pristine film to 2.20 eV for 20 min. The dispersion of refractive index and complex dielectric constants under plasma treatment was also studied. Variation of color parameters under effect of the plasma treatment is analyzed in the framework of CIE L*U*V* color space.

Synthesis, characterization, optical and antimicrobial studies of polyvinyl alcohol-silver nanocomposites.

Silver nanoparticles (Ag NPs) were synthesized by chemical reduction of silver salt (AgNO3) through sodium borohydride. The characteristic surface plasmon resonance band located at around 400nm in the UV-Visible absorption spectrum confirmed the formation of Ag nanoparticles. Polyvinyl alcohol-silver (PVA-Ag) nanocomposite films were prepared by the casting technique. The morphology and interaction of PVA with Ag NPs were examined by transmission electron microscopy and FTIR spectroscopy. Optical studies show that PVA exhibited indirect allowed optical transition with optical energy gap of 4.8eV, which reduced to 4.45eV under addition of Ag NPs. Optical parameters such as refractive index, complex dielectric constant and their dispersions have been analyzed using Wemple and DiDomenco model. Color properties of the nanocomposites are discussed in the framework of CIE L(∗)u(∗)v(∗) color space. The antimicrobial activity of the nanocomposite samples was tested against Gram positive bacteria (Staphylococcus aureus NCTC 7447 &Bacillus subtillis NCIB 3610), Gram negative bacteria (Escherichia coli, NTC10416 &Pseudomonas aeruginosa NCIB 9016) and fungi (Aspergillus niger Ferm - BAM C-21) using the agar diffusion technique. The antimicrobial study showed that PVA has moderate antibacterial activity against B. subtillis and the 0.04wt% Ag NPs composite sample effect was strong against S. aureus.

Synthesis, characterization and optical properties of gelatin doped with silver nanoparticles.

In this study, silver nanoparticles were synthesized by chemical reduction of silver salt (AgNO3) solution. Formation of nanoparticles was confirmed by UV-visible spectrometry. The surface plasmon resonance peak is located at 430 nm. Doping of silver nanoparticles (Ag NPs) with gelatin biopolymer was studied. The silver content in the polymer matrix was in the range of 0.4-1 wt%. The formation of nanoparticles disappeared for silver content higher than 1 wt%. The morphology and interaction of gelatin doped with Ag NPs was examined by transmission electron microscopy and FTIR spectroscopy. The content of Ag NPs has a pronounced effect on optical and structural properties of gelatin. Optical parameters such as refractive index, complex dielectric constant were calculated. The dispersion of the refractive index was discussed in terms of the single--oscillator Wemple-DiDomenico model. Color properties of the prepared samples were discussed in the framework of CIE L(*)u(*)v(*) color space.

Profound microcephaly, primordial dwarfism with developmental brain malformations: a new syndrome.

We describe two sibs with a lethal form of profound congenital microcephaly, intrauterine and postnatal growth retardation, subtle skeletal changes, and poorly developed brain. The sibs had striking absent cranial vault with sloping of the forehead, large beaked nose, relatively large ears, and mandibular micro-retrognathia. Brain magnetic resonance imaging (MRI) revealed extremely simplified gyral pattern, large interhemispheric cyst and agenesis of corpus callosum, abnormally shaped hippocampus, and proportionately affected cerebellum and brainstem. In addition, fundus examination showed foveal hypoplasia with optic nerve atrophy. No abnormalities of the internal organs were found. This profound form of microcephaly was identified at 17 weeks gestation by ultrasound and fetal brain MRI helped in characterizing the developmental brain malformations in the second sib. Molecular analysis excluded mutations in potentially related genes such as RNU4ATAC, SLC25A19, and ASPM. These clinical and imaging findings are unlike that of any recognized severe forms of microcephaly which is believed to be a new microcephalic primordial dwarfism (MPD) with developmental brain malformations with most probably autosomal recessive inheritance based on consanguinity and similarly affected male and female sibs.

Rabbit antithymocyte globulin: a postoperative risk factor for sirolimus-treated renal transplant patients?

AIMS: Randomized controlled studies suggest an increased incidence of perioperative wound complications among sirolimus-treated renal transplant patients. The present study analyzed the effect of rabbit antithymocyte globulin (rATG) on these postoperative complications. METHODS: Four hundred and twelve renal transplants were performed and managed postoperatively at two University-affiliated hospitals between January 1, 2001, and December 31, 2003. The patients received corticosteroids and Sirolimus, with delayed introduction of cyclosporine when the serum creatinine had decreased below 2.5 mg/dL. Two groups of patients were discriminated: group 1 received Basiliximab 20 mg on day 0 and day 4 (n = 283); group 2 recipients with a high panel of reactive antibody (PRA > 20%) and retransplant patients received rATG for induction (n = 129) for a maximum of 2 weeks postoperatively. The incidence of rejection was 14.5% for group 1 vs. 8.5% for group 2 patients. To avoid confounding variable associated with the rejection treatment, any patient with rejection was excluded for statistical analysis, as were patients with follow- up less than 30 days. The final study group for analysis included 350 patients: 235 with Basiliximab induction (group 1) and 115 rATG induction (group 2). The mean follow-up was 21.8 +/- 11 months. Differences in the incidences of postoperative hernia, wound infections, or lymphoceles requiring any form of drainage were analyzed for statistical significance using the chi-square test. RESULTS: The percentage of patients with wound complications was 26.0% versus 39.1% (P < .025) for group 1 versus group 2, respectively. Incisional hernias occurred in 10.6% versus 18.3% patients (P < .05), wound infections in 11.1% versus 16.5% (P = NS), and lymphoceles in 10.6% versus 15.9% (P = NS) for the two groups, respectively. CONCLUSIONS: rATG-induced renal transplants recipients treated with sirolimus, cyclosporine, and steroids show a significantly increased incidence of postoperative incisional hernias and a trend toward a greater number of lymphocele and wound infection complications.