1.
Bioorg Med Chem Lett
; 19(20): 5950-3, 2009 Oct 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19762236
RESUMEN
We describe a novel series of potent inhibitors of the kinase activity of mTOR. The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit good antiproliferative activity.