RESUMEN
OBJECTIVE: To report a pilot project of expert nurses for outpatient parenteral antimicrobial treatment (OPAT) follow-up. METHODS: Three nurses with specific training on antibiotics started a state-funded programme including: i) consultations for OPAT follow-up; ii) hotline for satellite hospitals; iii) peer training. Patients' data were prospectively collected. A representative sample of patients and physicians was interviewed to learn about their opinion on the project. RESULTS: From December 2020 to December 2021, 118 patients (median age 66.5 years [52-75], male-to-female ratio 2.5) were enrolled, for a total of 621 consultations. Patients were mostly on OPAT for bone and joint infections (n = 76, 64 %) and cardiovascular infections (n = 16, 14 %), for a median duration of 29 days [22-57]. Eleven patients (9 %) required unplanned hospital admissions, and three experienced treatment failure. Most patients (21/22) and physicians in charge (10/10) reported a high level of satisfaction. CONCLUSIONS: Nurses may be important actors for OPAT follow-up.
Asunto(s)
Antiinfecciosos , Enfermeras y Enfermeros , Humanos , Masculino , Femenino , Anciano , Proyectos Piloto , Estudios de Seguimiento , Antiinfecciosos/uso terapéutico , Infusiones IntravenosasRESUMEN
PURPOSE: To study the results of femtosecond laser-assisted arcuate keratotomy in extreme astigmatism after penetrating keratoplasty, using a Ziemer LDVZ6 with a modified Lindstrom nomogram. DESIGN: Case series, retrospective study. METHOD: Consecutive eyes that underwent femtosecond laser-assisted arcuate keratotomy between 2014 and 2019 in the Nantes University Hospital for extreme astigmatism after penetrating keratoplasty were included. RESULTS: Twenty-four eyes of 24 patients were included. The mean age was 53.3±12.2 years at the time of the arcuate keratotomies. Indications for penetrating keratoplasty were keratoconus in 66.7% of cases, herpes keratitis in 16.7% of cases, and corneal dystrophy in 16.7% of cases. The mean initial best corrected visual acuity was 0.36±0.23 logMar versus 0.26±0.15 logMar at the 3-month postoperative visit (P=0.04). At the postoperative visit, 54% (13/24) of eyes had improved best corrected visual acuity (BCVA), and 25% had no change in BCVA, with a mean cylinder reduction of 3.3 diopters. The mean preoperative topographic cylinder was 9.5±3.2 diopters versus 6.2±2.8 diopters postoperatively (absolute values; P<0.001), i.e. a 34.7% reduction in astigmatism. At the 3-month postoperative visit, 20.8% of eyes (5/24) had topographic astigmatism less than 3 diopters with a mean astigmatism reduction of 97±55% (range: 17; 201) using the Alpins method. No suppurative keratitis or endophthalmitis were observed. Twenty-one percent of patients underwent a second arcuate keratotomy after 3 to 6 months due to insufficient refractive results. CONCLUSION: Development of new nomograms designed for extreme astigmatism after penetrating keratoplasty would enhance the precision and reproducibility of femtosecond laser-assisted arcuate keratotomy in these cases.
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Astigmatismo , Adulto , Anciano , Astigmatismo/diagnóstico , Astigmatismo/etiología , Astigmatismo/cirugía , Topografía de la Córnea , Humanos , Queratoplastia Penetrante/efectos adversos , Rayos Láser , Persona de Mediana Edad , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/cirugía , Refracción Ocular , Reproducibilidad de los Resultados , Estudios Retrospectivos , Agudeza VisualAsunto(s)
Coriorretinitis , Verde de Indocianina , Adalimumab/uso terapéutico , Retinocoroidopatía en Perdigonada , Coriorretinitis/diagnóstico , Coriorretinitis/tratamiento farmacológico , Coriorretinitis/patología , Coroides/diagnóstico por imagen , Coroides/patología , Angiografía con Fluoresceína , HumanosAsunto(s)
Úlcera de la Córnea/diagnóstico , Úlcera de la Córnea/microbiología , Infecciones Bacterianas del Ojo/diagnóstico , Oftalmopatía de Graves/complicaciones , Klebsiella oxytoca/aislamiento & purificación , Pasteurella multocida/aislamiento & purificación , Anciano , Amnios/trasplante , Antibacterianos/administración & dosificación , Ceftazidima/administración & dosificación , Ciprofloxacina/administración & dosificación , Coinfección/complicaciones , Coinfección/diagnóstico , Coinfección/microbiología , Terapia Combinada , Úlcera de la Córnea/complicaciones , Úlcera de la Córnea/terapia , Farmacorresistencia Bacteriana/efectos de los fármacos , Quimioterapia Combinada , Infecciones Bacterianas del Ojo/complicaciones , Infecciones Bacterianas del Ojo/microbiología , Infecciones Bacterianas del Ojo/terapia , Femenino , Oftalmopatía de Graves/diagnóstico , Oftalmopatía de Graves/microbiología , Oftalmopatía de Graves/terapia , Humanos , Infecciones por Klebsiella/complicaciones , Infecciones por Klebsiella/diagnóstico , Infecciones por Klebsiella/microbiología , Infecciones por Klebsiella/terapia , Infecciones por Pasteurella/complicaciones , Infecciones por Pasteurella/diagnóstico , Infecciones por Pasteurella/microbiología , Infecciones por Pasteurella/terapiaAsunto(s)
Hiperoxaluria Primaria/complicaciones , Enfermedades de la Retina/etiología , Corticoesteroides/uso terapéutico , Oxalato de Calcio/metabolismo , Femenino , Humanos , Hiperoxaluria Primaria/diagnóstico , Hiperoxaluria Primaria/tratamiento farmacológico , Trasplante de Riñón , Persona de Mediana Edad , Enfermedades de la Retina/diagnóstico , Enfermedades de la Retina/tratamiento farmacológico , Enfermedades de la Retina/metabolismo , Tomografía de Coherencia ÓpticaRESUMEN
An attempt was made to determine the relationship between the characteristics of electrical activity of the hypertrophied myocardium of rats at the cellular level and at the level of the whole heart after a one-month left ventricular pressure overload. Such an animal model has already been demonstrated to be highly resistant to epinephrine-induced arrhythmias. Since severe ventricular arrhythmias often occur in patients with cardiac hypertrophy, ventricular vulnerability might depend on some electrophysiological characteristics of the heart related to the stage of hypertrophy. Using the "floating" microelectrode technique, the computed characteristics of cardiac transmembrane action potentials (AP) of the left and right epicardium cells were compared in situ to computed characteristics of the electrocardiograms in anaesthetized control rats (group C) and in rats with left ventricular hypertrophy (group H) induced by a one-month suprarenal constriction of the abdominal aorta. The aortic pressure overload caused a significant (p<0.001) and marked increase in AP duration of left ventricular cells: APD 30 and APD 80 were 29+/-3 ms and 89+/-6 ms, respectively, in group H and 14+/-1 ms and 53+/-2 ms in group C. The same modifications were observed in right ventricular cells when right hypertrophy was present. Simultaneous electrocardiograms exhibited a significant (p<0.01) prolongation of P-R, Q-S and T duration and T wave flattening in group H (63+/-2 ms, 32+/-3 ms, 109+/-5 ms and 0.25+/-0.03 mV as compared with 53+/-1 ms, 20+/-1 ms, 88+/-2 ms and 0.40+/-0.04 mV in group C). After a one-month aortic overload in rats, both left and right ventricles are hypertrophied and have the same electrophysiological characteristics: in this model, at this stage of hypertrophy, some factors favouring ventricular arrhythmias are missing. The corresponding flattening of the T wave in the ECG might be of clinical relevance.