RESUMEN
Meditative practices can vary considerably in technique as well as their effects. Heartfulness is a popular meditation technique that includes in its repertoire, a unique passive form of meditation. We carried out a pilot study recruiting male heartfulness meditators (proficient n = 24, with 6-28 years of meditation experience; novice n = 24, 5 to 16 months of experience) and subsequently recruited matched controls (n = 15). We examined well-being, and carried out high-density EEG recordings to examine indices of meditation and cognition in these groups. Well-being scores were significantly higher for the proficient meditators as compared to novice and intermediate for the controls. We did not find any group differences in cognitive processing. During meditation, enhanced occipital gamma was found in proficient meditators as compared to controls. We discuss the findings from this pilot study and suggest avenues for future research.
Asunto(s)
Meditación , Cognición , Humanos , Masculino , Proyectos PilotoRESUMEN
We disclose the discovery of a novel series of tetrahydropyrido-pyrazoles that are potent inhibitors of tumour necrosis factor-alpha (TNF-α), nitric oxide and cannabinoid receptor subtype 1 (CB1). We report herein the synthesis and neuropharmacological screening results of the titled compounds in two acute pain and two neuropathic pain models in rodents. Particularly the analogue N-(4-bromophenyl)-3-tert-butyl-5-ethyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-1-carboxamide (8a) exhibited pronounced acute antinociceptive efficacy, also being effective in chronic constriction injury (ED50 = 23.8 mg/kg) and partial sciatic nerve injury (ED50 = 29.0 mg/kg) models with CB1 receptor activity (IC50 = 49.6 nM) and inhibitory effect on TNF-α (86.4% inhibition at 100 mg/kg). These results suggest the importance of the development of this lead as multi-targeted treatment strategy for neuropathic pain.
