Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros












Base de datos
Intervalo de año de publicación
1.
Gastroenterology ; 167(2): 333-342, 2024 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-38401741

RESUMEN

BACKGROUND & AIMS: The efficacy of a low fermentable oligo-, di-, monosaccharides and polyols (FODMAP) diet in irritable bowel syndrome (IBS) is well established. After the elimination period, a reintroduction phase aims to identify triggers. We studied the impact of a blinded reintroduction using FODMAP powders to objectively identify triggers and evaluated the effect on symptoms, quality of life, and psychosocial comorbidities. METHODS: Responders to a 6-week low FODMAP diet, defined by a drop in IBS symptom severity score (IBS-SSS) compared with baseline, entered a 9-week blinded randomized reintroduction phase with 6 FODMAP powders (fructans, fructose, galacto-oligosaccharides, lactose, mannitol, sorbitol) or control (glucose). A rise in IBS-SSS (≥50 points) defined a FODMAP trigger. Patients completed daily symptom diaries and questionnaires for quality of life and psychosocial comorbidities. RESULTS: In 117 recruited patients with IBS, IBS-SSS improved significantly after the elimination period compared with baseline (150 ± 116 vs 301 ± 97, P < .0001, 80% responders). Symptom recurrence was triggered in 85% of the FODMAP powders, by an average of 2.5 ± 2 FODMAPs/patient. The most prevalent triggers were fructans (56%) and mannitol (54%), followed by galacto-oligosaccharides, lactose, fructose, sorbitol, and glucose (respectively 35%, 28%, 27%, 23%, and 26%) with a significant increase in abdominal pain at day 1 for sorbitol/mannitol, day 2 for fructans/galacto-oligosaccharides, and day 3 for lactose. CONCLUSION: We confirmed the significant benefit of the low FODMAP diet in tertiary-care IBS. A blinded reintroduction revealed a personalized pattern of symptom recurrence, with fructans and mannitol as the most prevalent, and allows the most objective identification of individual FODMAP triggers. Ethical commission University hospital of Leuven reference number: s63629; Clinicaltrials.gov number: NCT04373304.


Asunto(s)
Dieta Baja en Carbohidratos , Disacáridos , Fermentación , Síndrome del Colon Irritable , Lactosa , Manitol , Monosacáridos , Oligosacáridos , Calidad de Vida , Humanos , Síndrome del Colon Irritable/dietoterapia , Femenino , Masculino , Adulto , Persona de Mediana Edad , Oligosacáridos/administración & dosificación , Oligosacáridos/efectos adversos , Manitol/administración & dosificación , Manitol/efectos adversos , Dieta Baja en Carbohidratos/métodos , Dieta Baja en Carbohidratos/efectos adversos , Resultado del Tratamiento , Lactosa/efectos adversos , Lactosa/administración & dosificación , Monosacáridos/administración & dosificación , Monosacáridos/efectos adversos , Disacáridos/administración & dosificación , Disacáridos/efectos adversos , Polímeros/administración & dosificación , Fructosa/administración & dosificación , Fructosa/efectos adversos , Sorbitol/administración & dosificación , Sorbitol/efectos adversos , Fructanos/administración & dosificación , Fructanos/efectos adversos , Índice de Severidad de la Enfermedad , Método Doble Ciego , Encuestas y Cuestionarios , Polvos , Recurrencia , Adulto Joven , Dieta FODMAP
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...