[Prevalence of Chronic Obstructive Pulmonary Disease in a Rural Area of Guadalajara, Spain]. / Prevalencia de la enfermedad pulmonar obstuctiva crónica en una zona rural de Guadalajara.

OBJECTIVE: The aim of this study was to establish the prevalence of Chronic obstructive pulmonary disease [COPD] in a rural health area and its stratification according different risk factors. METHODS: A cross-sectional, observational study was performed in Yunquera de Henares (Guadalajara, Spain) in the year 2014. A questionnaire on sociodemographic factors, tobacco consumption, age, education level and occupation was used in a randomized, stratified sample in different stages. The sample was proportional in age, sex and population centers. A total of 749 persons were included. Data were analyzed using descriptive, analytical, and multivariant statistical procedures and logistical regression. RESULTS: The prevalence of COPD was 15.8% (CI95%: 13.2-18.4) and was statistically significantly higher in elderly (64.6±11 years vs 58.9±11,7 years); males (83.2%;CI95%:85.9-80.5),smokers (40.3%;CI95%:43.8-36.8) and people with primary education (66.4%;CI95%:69.7-63). People with COPD had higher BMI (28.2%;IC95%:29.5-26.9). People working in the field was 28.6% (IC95%:20,5-36,7%). CONCLUSIONS: A high prevalence of Chronic Obstructive Pulmonary Disease was found. Occupational exposure may be an important factor in rural areas.

OBJETIVO: El objetivo de este estudio fue establecer la prevalencia de enfermedad pulmonar obstructiva crónica en una zona básica de salud de ámbito rural y el análisis según diferentes factores de riesgo. METODOS: Estudio transversal realizado en Yunquera de Henares (Guadalajara) durante 2014. Para la recogida de información se utilizó un cuestionario que recogió datos sociodemograficos, consumo de tabaco, edad, nivel de estudios y ocupación en una muestra de sujetos seleccionada de manera aleatoria y estratificada según edad, sexo y núcleos de población. El tamaño muestral fue de 749 personas. Se realizó análisis estadístico descriptivo con medias y porcentajes, analítico: chi2, t de Student, ANOVA y multivariante por regresión logística. RESULTADOS: La prevalencia de enfermedad pulmonar obstructiva crónica fue del 15,8% (IC95%: 13,2-18,4).Las personas con enfermedad pulmonar obstructiva crónica tenían una edad media de 64,6±11 años vs 58,9±11,7 de quienes no la padecían. Eran hombres el 83,2% (IC95%: 85,9-80,5), fue más frecuente en personas con estudios primarios: 66,4% (IC95%: 69,7-63) y entre quienes consumían tabaco: 40,3% (IC 95%: 43,8-36,8). De manera no estadísticamente significativa, también presentaban mayor índice de masa corporal:28,2% (IC95%: 29,5-26,9).Trabajababan en el campo el 28,6% (IC95%: 20,5-36,7). CONCLUSIONES: La prevalencia de enfermedad pulmonar obstructiva crónica encontrada fue alta. La exposición laboral puede ser un factor importante en el medio rural.

Morphology and morphometric relationships of the sagitta of Diapterus auratus (Perciformes: Gerreidae) from Veracruz, Mexico.

Sagittae otoliths are the most studied because of their morphological variability and size; the sagittae may also have valuable taxonomic use and for D. auratus has not yet been described. In the present study we present a morphological description of the sagitta otolith and an analysis of its correlation with various morphometric parameters. The biological material was captured with a beach seine in the coasts of Alvarado and Port of Veracruz, from November 2009 to June 2010. Sagittae were extracted, cleaned, photographed (SEM and optical), and measured. The analysis included the correlations between sagitta's length and width, versus the fish standard length, height and weight, for a total of 449 fishes. The comparison between left and right sagitta showed no significant difference in both otolith length and width (t-tests, p<0.05) for each sex. The right otolith was used for the correlations for both males and females and the Fisher test (d.f. 161 and 143, p<0.001) showed no significant differences in the slopes and intersections between them. The otolith length vs. fish weight correlation showed a positive allometric growth in males (b=3.9754, p<0.05) and females (b=4.3168, p<0.05).

Morphology and morphometric relationships of the sagitta of Diapterus auratus (Perciformes: Gerreidae) from Veracruz, Mexico

Sagittae otoliths are the most studied because of their morphological variability and size; the sagittae may also have valuable taxonomic use and for D. auratus has not yet been described. In the present study we present a morphological description of the sagitta otolith and an analysis of its correlation with various morphometric parameters. The biological material was captured with a beach seine in the coasts of Alvarado and Port of Veracruz, from November 2009 to June 2010. Sagittae were extracted, cleaned, photographed (SEM and optical), and measured. The analysis included the correlations between sagitta’s length and width, versus the fish standard length, height and weight, for a total of 449 fishes. The comparison between left and right sagitta showed no significant difference in both otolith length and width (t-tests, p<0.05) for each sex. The right otolith was used for the correlations for both males and females and the Fisher test (d.f. 161 and 143, p<0.001) showed no significant differences in the slopes and intersections between them. The otolith length vs. fish weight correlation showed a positive allometric growth in males (b=3.9754, p<0.05) and females (b=4.3168, p<0.05).

Los otolitos sagitta son los más estudiados debido a su variabilidad morfológica y a su tamaño, sin embargo, los otolitos de D. auratus no han sido estudiados hasta el momento. En el presente estudio, se muestra una descripción completa de la morfología y un análisis morfométrico de diversas medidas. El análisis incluye las relaciones entre el ancho y largo de la sagitta contra la longitud cefálica, longitud estándar, altura y peso de 449 peces. El material biológico fue capturado con un chinchorro playero en las costas de Alvarado y el Puerto de Veracruz de noviembre 2009 a junio 2010. Las sagittae fueron extraídas, limpiadas, fotografiadas (SEM y ópticas) y medidas. La comparación entre el otolito derecho e izquierdo no mostró diferencias significativas entre el ancho y largo (prueba de t, p<0.05) para cada sexo. El otolito derecho fue utilizado para las relaciones de las distintas medidas del otolito del pez y del otolito de hembras y machos; la prueba de Fisher (d.f. 161 and 143, p<0.001) no mostró diferencias significativas de las pendientes e intersecciones entre ellos. La relación longitud del otolito-peso del pez mostró un crecimiento de tipo alométrico positivo en machos (b=3.9754, p<0.05) y hembras (b=4.3168, p<0.05).

Assessing osteoporosis risk factors in Spanish menopausal women.

OBJECTIVES: (1) To assess the prevalence of osteoporosis risk factors in Spanish menopausal women; (2) to detect medical and lifestyle risk factor differences between perimenopausal and postmenopausal women; (3) and to identify the main factors responsible for osteoporosis. METHODS: Cross-sectional descriptive study encompassing women aged 45-65 across Spain. The study population sample was collected through random sampling and a total of 10,514 women were included. Socio-demographic, medical history, and lifestyle data were assessed. RESULTS: The prevalence of osteoporosis risk factors was 67.6%. The most common risk factors were physical inactivity (53.6%), use of medication related to osteoporosis risk (45.9%), and low calcium intake (30.1%). There were statistically significant differences between peri- and postmenopausal women in terms of smoking status, alcohol intake, personal history, poor dairy product intake, and medication use that could increase risk. Logistic regression analysis showed that osteoporosis was significantly associated with age, family history, age at onset of menopause, Kupperman Index, prolonged immobilization, weight loss, and other diseases that increase the probability of developing osteoporosis. CONCLUSIONS: A high prevalence of women taking osteoporosis risk-related medication was observed in our study. There was correlation between the menopausal symptoms' degree of severity and the risk of suffering from osteoporosis.

Life-style activities in older people without intellectual impairment: a population-based study.

INTRODUCTION: Activities of daily living are important indicators of the functional status and wellbeing of older persons. Data derived from life-style activities of the community at large are important for such diverse purposes as characterising the individual's ability for independent living, studying normal ageing, or investigating social factors in rehabilitation. Our objective was to determine patterns in the life-style activities of people aged 65 years and older who had no intellectual impairment. METHODS: The article is a cross-sectional study of a population-based sample. Eligible people were non-institutionalised and aged 65 years or older, resident in the province of Guadalajara, Spain, and without intellectual impairment as assessed by the 10-item Short Portable Mental Status Questionnaire. Questionnaires were administered by trained interviewers and included questions about the daily activities of the Adelaide Activities Profile (AAP), distributed among the four categories of domestic chores, household maintenance, service to others, and social activities. Each item was rated 0 = absent or 1 = present, and total scores ranged from 0 to 19. RESULTS: The sample included 192 men and 196 women from rural areas and 172 men and 220 women from urban areas. In the category of domestic chores, mean ratings for women (4.56, 95% CI 4.30 to 4.84) were significantly higher (p <0.05) than for men (1.36, 95% CI 1.11 to 1.62) both in urban and rural areas, except in the oldest age group (> or =85 years). In the subscale of household maintenance, also except for group of > or =85 years, men rated significantly higher (3.31, 95% CI 3.11 to 3.53) than women (2.34, 95% CI 2.21 to 2.47), independent of the place of residence. Women scored significantly higher than men in activities associated with service to others. Men younger than 80 years from rural areas were significantly more involved in social activities than women. In urban areas both sexes scored similarly in social activities CONCLUSION: The differences found among the AAP scales in relation to gender was a clear indication of the well established roles for men and women in our sociocultural context. The 19-item version of the AAP scale is a valuable survey instrument as an objective guide for studying activities related to life-style in community settings.

New Synthetic Strategies to Vitamin D Analogues Modified at the Side Chain and D Ring. Synthesis of 1alpha,25-Dihydroxy-16-ene-vitamin D(3) and C-20 Analogues(1).

Two efficient synthetic routes to 1alpha,25-dihydroxy-16-ene-vitamin D(3) (4a) and their C-20 analogues (3 and 4) have been developed. Key features common to both routes A and B are the introduction of side chains functionalized at C20 (17, 21, 19, and 25). In route A the CD side chain fragments 5 and 6 are prepared by S(N)2' syn displacement of allylic carbamates 8 and 9 (X = OCONHPh) by Li(2)Cu(3)R(5). The triene unit is then constructed by assembling the latter fragments with the A-ring fragment using the Wittig-Horner method (average yield of vitamin D analogue 35%, 11-13 steps from ketone 11). In route B, the S(N)2' syn displacement of the carbamate moiety by Li(2)Cu(3)R(5) is carried out on intermediates 12 and 13, both of which bear the vitamin D triene unit (average yield of vitamin D analogue 27%, 13-15 steps from ketone 11). The latter route is particularly attractive as an approach to diverse C-20 vitamin D analogues for biological screening.