RESUMEN
OBJECTIVES: To evaluate the effect of Mifepristone (25 mg) on symptomatic myoma in perimenopausal women. STUDY DESIGN: Open label clinical trial. MATERIALS AND METHODS: Ninety three perimenopausal women of age 35-50 years having symptomatic myoma were selected from Gynecology OPD and given 25 mg Mifepristone once daily continuously for three months. Variables as; baseline uterine size, uterine volume, myoma size, volume, their number, position, characteristics, hemoglobin and blood parameters, were taken and followed monthly for six months. Bleeding and pain scores were checked on monthly visits. Changes in above parameters were tabulated during the first three months treatment phase and then next three post-treatment phase for analysis. STATISTICAL ANALYSIS: Was done by calculating mean, standard deviation, standard error and percentage distribution of variables. RESULTS: Menorrhagia was the most common symptom which led patients to report to hospital. Mean uterine volume reduced to 63.69% of baseline, Mean dominant Myoma volume reduced to 53.62% and hemoglobin level raised to 137% after complete three months of treatment. Changes persisted in next three months post-treatment follow-up, while hysterectomy was required in 10 (12.2%) cases. CONCLUSION: Three months treatment of 25 mg Mifepristone effectively controls bleeding, reduces the uterine and myoma volume and thus can avoid blood transfusion and hysterectomy in a lot of symptomatic myoma cases.
RESUMEN
During the period of study, 85 dialysis clearance periods were studied in a total of 42 dialyses. Peritoneal clearance of urea and creatinine were observed at varying flow rates of dialysing fluid ranging from 2 litres/hour to 8.5 litres/hour. Flow rates were adjusted to various speeds with indigineously designed diaphragm pump. The diaphragm pump is cheap and simple and has an electronically controlled timer. A linear correlation was observed between dialysate flow rate and peritoneal clearances. With this semicontinuous rapid flow, high volume exchange peritoneal dialysis technique described in this study, correction of serum potassium disturbance is found to be excellent even in shorter periods.
