Silicon microfabrication technologies for biology integrated advance devices and interfaces.

Miniaturization is the trend to manufacture ever smaller devices and this process requires knowledge, experience, understanding of materials, manufacturing techniques and scaling laws. The fabrication techniques used in semiconductor industry deliver an exceptionally high yield of devices and provide a well-established platform. Today, these miniaturized devices are manufactured with high reproducibility, design flexibility, scalability and multiplexed features to be used in several applications including micro-, nano-fluidics, implantable chips, diagnostics/biosensors and neural probes. We here provide a review on the microfabricated devices used for biology driven science. We will describe the ubiquity of the use of micro-nanofabrication techniques in biology and biotechnology through the fabrication of high-aspect-ratio devices for cell sensing applications, intracellular devices, probes developed for neuroscience-neurotechnology and biosensing of the certain biomarkers. Recently, the research on micro and nanodevices for biology has been progressing rapidly. While the understanding of the unknown biological fields -such as human brain- has been requiring more research with advanced materials and devices, the development protocols of desired devices has been advancing in parallel, which finally meets with some of the requirements of biological sciences. This is a very exciting field and we aim to highlight the impact of micro-nanotechnologies that can shed light on complex biological questions and needs.

Demonstration of error-free 25Gb/s duobinary transmission using a colourless reflective integrated modulator.

To realise novel, low-cost, photonic technologies that can support 100Gb/s Ethernet in next-generation dense wavelength-division-multiplexed metro transport networks, we are developing arrayed photonic integrated circuits that leverage colourless reflective modulators. Here, we demonstrate a single-channel, hybrid reflective electroabsorption modulator-based device, showing error-free 25.3Gb/s duobinary transmission with bit-error rates less than 1 × 10(-12) over 35km of standard single-mode fibre. We further confirm the modulator's colourless operation over the ITU C-band, with a 1.2dB variation in required optical signal-to-noise ratio over this wavelength range.