1.
Bioorg Med Chem Lett
; 18(4): 1402-6, 2008 Feb 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-18243691
RESUMEN
This paper describes the lead optimization of a new series of potent, selective, orally bioavailable, brain-penetrant MCH-1 receptor antagonists. A major focus of the work was to achieve a selectivity profile appropriate for in vivo efficacy studies and safety.