RESUMEN
Discoid (nummular) eczema is a common and distinctive eczema variant, which has not been studied in depth. Although the principles of management are similar to that of classic atopic dermatitis, distinctions are made due to its unique presentation and persistent clinical course in children. Australian and New Zealand dermatologists with an interest in paediatric eczema developed a consensus narrative to assist clinicians in diagnosing and treating this subtype of eczema. Identifying triggers, potent topical corticosteroids under occlusion, skin barrier support and management of pruritus are first-line therapies, however, many eventually require systemic immunomodulatory agents.
Asunto(s)
Dermatitis Atópica , Fármacos Dermatológicos , Eccema , Niño , Humanos , Nueva Zelanda , Australia , Eccema/diagnóstico , Eccema/tratamiento farmacológico , Dermatitis Atópica/tratamiento farmacológico , Fármacos Dermatológicos/uso terapéuticoAsunto(s)
Biomarcadores de Tumor/genética , Melanoma/genética , Nevo Pigmentado/genética , Neoplasias Cutáneas/genética , Adulto , Anciano , Australia/epidemiología , Estudios de Casos y Controles , Dermoscopía/estadística & datos numéricos , Femenino , Estudio de Asociación del Genoma Completo , Humanos , Masculino , Melanoma/diagnóstico por imagen , Melanoma/epidemiología , Persona de Mediana Edad , Nevo Pigmentado/diagnóstico por imagen , Oportunidad Relativa , Polimorfismo de Nucleótido Simple , Medición de Riesgo/métodos , Factores de Riesgo , Neoplasias Cutáneas/diagnóstico por imagen , Neoplasias Cutáneas/epidemiología , Adulto JovenRESUMEN
Changes in dermoscopic patterns of naevi may be associated with melanoma; however, there is no consensus on which dermoscopic classification system is optimal. To determine whether different classification systems give comparable results and can be combined for analysis, we applied two systems to a case-control study of melanoma with 1037 participants: 573 classified using a "1/3 major feature" system, 464 classified based on rules of appearance, and 263 classified with both criteria. There was strong correlation for non-specific (Spearman R = 0.96) and reticular (Spearman R = 0.82) naevi, with a slight bias for globular naevi with the rules of appearance system. Inter-observer reliability was high for the rules of appearance system, particularly for reticular naevi (Pearson >0.97). We show that different classification systems for naevi can be combined for data analysis, and describe a method for determining what adjustments may need to be applied to combine data sets.
