Optimization of On-Demand Shared Autonomous Vehicle Deployments Utilizing Reinforcement Learning.

Ride-hailed shared autonomous vehicles (SAV) have emerged recently as an economically feasible way of introducing autonomous driving technologies while serving the mobility needs of under-served communities. There has also been corresponding research work on optimization of the operation of these SAVs. However, the current state-of-the-art research in this area treats very simple networks, neglecting the effect of a realistic other traffic representation, and is not useful for planning deployments of SAV service. In contrast, this paper utilizes a recent autonomous shuttle deployment site in Columbus, Ohio, as a basis for mobility studies and the optimization of SAV fleet deployment. Furthermore, this paper creates an SAV dispatcher based on reinforcement learning (RL) to minimize passenger wait time and to maximize the number of passengers served. The created taxi-dispatcher is then simulated in a realistic scenario while avoiding generalization or over-fitting to the area. It is found that an RL-aided taxi dispatcher algorithm can greatly improve the performance of a deployment of SAVs by increasing the overall number of trips completed and passengers served while decreasing the wait time for passengers.

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies. Here, we describe Onco-GPS (OncoGenic Positioning System), a data-driven analysis framework to organize individual tumor samples with shared oncogenic alterations onto a reference map defined by their underlying cellular states. We applied the methodology to the RAS pathway and identified nine distinct components that reflect transcriptional activities downstream of RAS and defined several functional states associated with patterns of transcriptional component activation that associates with genomic hallmarks and response to genetic and pharmacological perturbations. These results show that the Onco-GPS is an effective approach to explore the complex landscape of oncogenic cellular states across cancers, and an analytic framework to summarize knowledge, establish relationships, and generate more effective disease models for research or as part of individualized precision medicine paradigms.