Formulary availability and regulatory barriers to accessibility of opioids for cancer pain in Africa: a report from the Global Opioid Policy Initiative (GOPI).

With nearly 1.1 billion inhabitants living in more than 50 countries, Africa is the world's poorest and most socioeconomically underdeveloped continent. Despite some advances for individual states, many African countries have very low opioid consumption and, overall, the continent has the lowest consumption per capita of any in the world. This article presents the findings of the first systematic study of the availability and accessibility of opioids for the management of cancer pain across the continent. Data are reported on the availability and accessibility of opioids for the management of cancer pain in 25 of 52 countries, with 744 million of the region's 1127 million people (66%) covered by the survey. Many countries had severely restricted formularies of opioids and only 15 of 25 had morphine available in oral IR, CR and injectable formulations. Even when opioids are on formulary they are often unavailable, and access is significantly impaired by widespread over-regulation that is pervasive across the region.

'A bridge to the hospice': the impact of a Community Volunteer Programme in Uganda.

In Africa, the need for palliative care provision is escalating with an increasing number of people living with HIV/AIDS, coupled with rising cancer and AIDS-related cancer diagnoses. In Uganda there is a shortage of doctors, particularly in rural areas. To address this Hospice Africa Uganda developed a Community Volunteer Programme to train volunteers to help by providing support to patients in their own homes. The aim of this qualitative study was to evaluate the impact of the Community Volunteer Programme. Sixty-four interviews, with patients (21), community volunteer workers (CVWs) (32), and the hospice clinical teams (11) were conducted, using semi-structured digitally recorded individual, group and focus group interviews, at the Hospice Africa Uganda sites. The results reported the value of the Community Volunteer Programme, including the impact on patients and families, and how the CVWs acted as a 'bridge to the hospice' in identifying patients. Developing financial challenges that are emerging which could potentially impact on the programme were reported. The Community Volunteer Programme appears to be having a positive impact on patients, families and the hospice team, and is a model worthy of consideration by other developing countries to allow the expansion of palliative care.

Clinical variance in assessing risk of pressure ulcer development.

Nurses working in one area health service (AHS) in Sydney, Australia, expressed concern about the development of pressure ulcers in hospitalized patients. Anecdotal evidence suggested that a variety of approaches were being used to assess patients to identify those at risk of pressure ulcer development. A questionnaire was distributed to all registered nurses (n = 2113) in clinical settings within the AHS. Data were analysed using frequency distribution. The response rate was 40% (n = 850), of which 444 were useable. Nurses generally do not use a tool to assess pressure ulcer risk potential, but rely on a range of practice procedures and risk indicators. It is recommended that a pressure ulcer project group be established to evaluate existing tools or, if necessary, develop a tool for the assessment of patients to identify those at risk of developing pressure ulcers.

Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis.

BACKGROUND: Ligands of chemokine receptor CCR5, including MIP-1 alpha, MIP-1 beta, and RANTES, have been implicated in rheumatoid arthritis. OBJECTIVE: To test whether CCR5 d32 polymorphism has a negative association with rheumatoid arthritis in a New Zealand cohort. METHODS: 516 white patients with rheumatoid arthritis and 985 healthy controls were investigated by PCR amplification of the region flanking the known CCR5 d32 deletion, and the frequencies of CCR5 d32 compared. An early rheumatoid arthritis (ERA) cohort of 92 patients was followed prospectively for two years; disease severity and outcome were correlated with CCR5 d32 status. RESULTS: 12 control subjects (1.2%) were homozygous for d32; no d32 homozygous rheumatoid patients were detected (p = 0.012); 56 patients (10.9%) were heterozygous for the d32 polymorphism (d32/wt), compared with 169 controls (17.2%) (p = 0.0011). The CCR5 d32 allele frequency was lower in the rheumatoid patients than in the controls (frequencies of 0.054 and 0.098, respectively; p = 3.7 x 10(-5)). The frequency of CCR5 d32 did not differ significantly according to disease severity or outcome in the prospective ERA cohort, nor with HLA-DRB1 status. CONCLUSIONS: This study provides further evidence for a protective effect of the CCR5 d32 variant on rheumatoid arthritis, consistent with a role for CCR5 and its ligands in disease pathogenesis.

Pressure ulcer prevention and care: a survey of current practice.

The incidence and management of pressure ulcers in hospitalised patients is an ongoing concern for nurses. Efforts to prevent pressure ulcer development are plagued with inconsistencies and a general lack of best practice guidelines. Establishing current practice approaches to the assessment, prevention and management of pressure ulcers is a necessary first step in the implementation of evidence-based/best practice guidelines. Anecdotal evidence suggested a range of different approaches were being used in a Sydney metropolitan area health service (AHS) to assess patients to identify those at risk, to prevent pressure ulcers and to treat existing ulcers. A collaborative research project was undertaken to examine current practice and to explore the apparent clinical variance. It involved the distribution of a questionnaire to registered nurses working within the AHS (n = 2113) and a review of nursing policy documents in the various hospitals in the health service area. While the overall response rate was satisfactory (40%) many of the returned questionnaires were incomplete. Only 21% (n = 444) of the questionnaires were deemed suitable for analysis. The findings highlight a range of inconsistencies within and across nursing practice domains. Nurses generally do not use a tool to assess pressure ulcer risk potential, but rely on a range of practice procedures and risk indicators to determine risk potential of developing pressure ulcers. Repositioning patients is the most common approach used in an attempt to prevent the development of pressure ulcers, but additional measures are diverse. Most nurses seem to be familiar with modern wound dressings such as hydrocolloids, foams and alginates in the treatment of second and third stage ulceration. However, the care provided by some nurses reflects an adherence to outdated practices, including the use of water filled gloves, povidone iodine and gauze packing.

Making drugs available.

PIP: Since 1994, Hospice Uganda has been accepting referrals of AIDS patients. The hospice uses the World Health Organization's "analgesic ladder" (aspirin or paracetamol, codeine or dihydrocodeine, and morphine) to control pain in both cancer and AIDS patients. Whereas cancer patients generally require pain control for the rest of their lives, the pain of AIDS patients is often temporary and associated with infections. Outside of hospice settings, pain control may be impeded by health workers' lack of knowledge in this area, noninclusion of analgesics in basic drug kits, and limited access to codeine and morphine. Given the shortage of hospice spaces and physicians in Uganda, new strategies must be developed to make analgesics more accessible at the community level and to train other health workers to diagnose and treat pain.^ieng

The medical, social, and functional profile of Parkinson's disease patients.

The study looked at the medical, social, and functional aspects of 34 patients with idiopathic Parkinson's Disease (PD). Eighty-five percent were above 55 years and 35% were over 70 years. Twenty-four (71%) were males. Most patients had Stage II disease. Overall functional state of the patient correlated closely with the stage of Parkinson's disease. Patients were likely to be dependent if their disease severity was stage III or more. Eighteen (53%) patients would require a carer to be present at least part of the day and 3 (9%) patients would require a carer most of the time. Domestic chores such as meal preparation, housework, and shopping were also affected in most of those who were previously active in these tasks. Ten patients had given up work due to their Parkinson's disease. The lack of knowledge of the disease was shown both in the carers and the patients. Twenty-nine of the patients had no knowledge of the disease, and only one carer had superficial knowledge of the disease. The major social problems associated with the disease were loss of social contact, behavioural problems, family members under strain and communication problems within the family. Since Parkinson's Disease is a chronic illness, with associated disabilities, it is important that the physician should aim for a multidisciplinary approach. Patient and carer education should be given emphasis, and the many everyday functional problems addressed. Advice on life-style management and aids to overcome disabilities may help improve quality of life of the patient and reduce carer's stress.

Clinical profile of elderly urinary incontinence in Singapore: a community-based study.

The prevalence of urinary incontinence in the elderly aged 65 years and above was found to be 4.6% (42 out of a total of 919 respondents), in a community-based study in Singapore. Urinary incontinence was defined as leakage of urine on at least two occasions in the previous one month. The clinical profile of 30 out of the 42 (71%) subjects were studied. There was equal distribution of male and female subjects. Eighteen (60%) of the subjects were below 75 years of age. Twenty-five (83.3%) subjects had severe incontinence. Twenty-four (80%) had the incontinence for more than one year. Despite the high percentage of patients with severe incontinence, only nine (30%) used some form of aid. Incontinence in our very old (75 years and above) was not related to frailty or physical dependence. Seven of the subjects (23.3%) were found to have functional incontinence associated with cognitive impairment. These patients were unable to indicate their toilet needs. They also had associated physical disability as well as double incontinence, and their carers were under stress. Ten of the subjects had pure urge incontinence. Seven of them had an underlying central nervous system disorder, suggesting that destrusor hyperreflexia may be the underlying cause for urinary incontinence in this group. All except one in this group had more than one possible precipitating factor for their incontinence. Eleven subjects had symptoms suggestive of outlet obstruction, although only two were found to have proven outlet obstruction. None of the female subjects had pure stress incontinence.(ABSTRACT TRUNCATED AT 250 WORDS)

Urinary incontinence among the elderly people of Singapore.

In a sample of 919 respondents aged 65 years and older, resident in a public housing estate in Singapore, the prevalence of regular urinary incontinence was 4.6%. Thirty-five of the 42 incontinent subjects consented to a detailed interview. The majority of these 35 cases leaked urine daily, leaked amounts over one tablespoon, or were suffering some psychological [corrected] or social effect of the incontinence. Urge incontinence was the commonest type in women and outlet obstruction in men. Almost all incontinent subjects were agreeable to having medical attention for the condition although over a third had not previously consulted medical personnel about the problem. There may be scope for the provision of primary health care continence services.

Reactions to death and dying by doctors, medical students and nurses in Singapore 1985-86.

Questionnaires concerning their own death were given to groups of general practitioners, final year medical students, 2nd year medical students, post-basic nurses, nurses working with the home nursing foundation and religious nursing sisters. The results of the questionnaire indicate that the majority wish to die at home with their families present, and would like spiritual advice. The majority of the respondents believe in a life after death. Although a minority fear death, most feared a prolonged dying process, troubling others and a painful death. Most want to be told if they are terminally ill, want to help prepare their families for matters after their death and wish to discuss their death with their relatives. For those who are actively involved in the care of the dying in Singapore, the questionnaire was extended to include their opinions on their own experience in the care of the dying. The majority were not satisfied with the level of care given. Further support for the professional carers in the form of multidisciplinary seminars, and the formation of a hospice movement was deemed necessary by the majority. The greatest indication of problems in satisfying the needs of the dying patient and the family is in the desire to legislate euthanasia by 23% of doctors and 38% of nurses.

Geriatric medicine in Singapore: quo vadis?

In this review article, the demography of Singapore and future needs for medical care for the elderly are discussed. Tracing the history of the development of the specialty in UK, the following conclusions can be drawn: Home visits for assessment by specialists can avoid many unnecessary hospital admissions by using existing community services. Elderly people fare badly in acute sectors of hospitals. Elderly people respond to, and need, rehabilitation. The elderly are poor reporters of illness. There have been, and still are, misunderstandings between general physicians and physicians in geriatric medicine as to their roles and the future of the specialty. The role of geriatric medicine versus general medicine is defined. The possibilities for the future role of geriatric medicine in Singapore are discussed. The present use of medical services by the elderly and financial implications are reviewed. Suggestions are made for research into a comprehensive type of medical care for the elderly in Singapore.

Findings among 100 type 2 diabetics in a clinic in Penang, Malaysia, 1983-84.

A Specialist Clinic was commenced in August 1983, from the Medical School at Universiti Sains Malaysia, Penang, Malaysia to assess: 1) the present control and 2) the incidence of complications in a diabetic population already receiving primary health care at Penang General Hospital. The ethnic groups among the diabetics were Chinese (39%), Malays (26%) and Indian (35%). There was a greater percentage of Indians than would be expected from the ethnic distribution of the population of Penang. The results of the first 100 (43 males and 57 females) non-insulin dependent diabetic patients are reviewed. The mean age was 54 years, 41% had relatives with diabetes, and all were taking oral agents. The diet comprehension and compliance were poor. 65% of the group, 54% of males and 75% of females were obese. The mean blood glucose was 11 m.mols/l (fasting) and 12.8 m.mols/1 (2 hours post prandial). The complications seen in the 100 diabetics were: albuminurea 41, skin infection 37, cataracts 35, hypertension 32, peripheral sensory neuropathy 32, retinopathy 22, ischaemic heart disease 19, autonomic neuropathy 10, impaired renal function 4 (urea or creatinine elevated), foot ulcer 2 and gangrene 1. Urinalysis for glucose at the Clinic showed very little correlation with blood glucose at the same time. Nine out of 43 males admitted to impotence on questioning. Comparisons of findings in Penang were made with recent studies in Singapore and Hong Kong.

Six cases of hyperosmolar non-ketotic diabetic decompensation in a hospital practice in West Africa.

During 1972, of 18 patients admitted to St. Luke's Hospital Anua, Uyo, in S.E. Nigeria, with diabetic metabolic decompensation, six were suffering from hyperglycaemic hyperosmolar non-ketotic coma or pre-coma. The clinical features and treatment of these patients are described. All survived. It is suggested that even when biochemical monitoring is unavailable, the overall mortality could be improved by clinical awareness of this commonly unrecognised condition, combined with replacement therapy using half strength normal saline and modest quantities of insulin and potassium.