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Rev Med Chir Soc Med Nat Iasi ; 113(3): 921-6, 2009.
Artículo en Rumano | MEDLINE | ID: mdl-20191856

RESUMEN

UNLABELLED: The aim of this work was to evaluate thermal stability of some W/O/W concentrated double emulsions (with 80% dispersed phase) containing 1% piroxicam following their theological behaviour at various temperatures. W/O/W double emulsions containing 1% piroxicam were prepared using the two-step procedure. RESULTS: The variable parameter of formulations was the hydrophilic macromolecule compound dispersed in the internal and external aqueous phases (hydroxyethylcellulose and Carbopol 940). Rheological behaviour and viscosity of the obtained W/O/W double emulsions was measured at 15 degrees C, 20 degrees C, 25 degrees C, 30 degrees C and 35 degrees C respectively, after preparation. The obtained results demonstrated that the studied W1/O/W2 double emulsions containing 1% piroxicam were stable under applied thermal stress, although they exhibited some differences in rheological properties caused by formulation variable.


Asunto(s)
Antiinflamatorios no Esteroideos/química , Piroxicam/química , Reología/métodos , Temperatura , Agua/química , Química Farmacéutica , Estabilidad de Medicamentos , Emulsiones/química , Humanos , Viscosidad
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