Asunto(s)
Tumores del Estroma Gastrointestinal/secundario , Neoplasias Cutáneas/secundario , Neoplasias Gástricas/patología , Anciano , Gastrectomía , Tumores del Estroma Gastrointestinal/patología , Tumores del Estroma Gastrointestinal/cirugía , Humanos , Inmunohistoquímica , Masculino , Neoplasias Cutáneas/patología , Neoplasias Gástricas/cirugía , Tejido Subcutáneo , Factores de TiempoAsunto(s)
Adenoma/diagnóstico , Colostomía/efectos adversos , Mucosa Intestinal/patología , Neoplasias Primarias Secundarias/diagnóstico , Complicaciones Posoperatorias/diagnóstico , Úlcera Cutánea/diagnóstico , Adenoma/patología , Anciano de 80 o más Años , Biopsia , Carcinoma/cirugía , Neoplasias del Colon/cirugía , Femenino , Humanos , Metaplasia/diagnóstico , Metaplasia/etiología , Metaplasia/patología , Neoplasias Primarias Secundarias/etiología , Neoplasias Primarias Secundarias/patología , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/patología , Piel/patología , Úlcera Cutánea/etiología , Úlcera Cutánea/patologíaRESUMEN
We report a 58-year-old woman with bronchial asthma. The onset of the disease was marked by numbness in the right lower extremity, for which she was hospitalized 10 days later. The patient presented with sensory impairment and muscle weakness in the distal regions of both lower limbs, acute pain, purpura, and a leukocyte count of 2.4 × 10(4)/µl (59.2% eosinophils). Nerve conduction tests revealed a decrease in the amplitude of the compound muscle action potential in all 4 extremities. Skin biopsy results led to the diagnosis of eosinophilic granulomatosis with polyangiitis (EGPA). Steroid pulse therapy and oral steroid therapy were initiated but did not resolve the acute pain or numbness. However, intravenous immunoglobulin (IVIg) was administered at day 28 after the beginning of the steroid treatment, and the pain started to improve immediately afterward. In some cases, IVIg can be effective in the treatment of intense pain in peripheral neuropathy associated with steroid-resistant EGPA.
Asunto(s)
Síndrome de Churg-Strauss/tratamiento farmacológico , Granulomatosis con Poliangitis/tratamiento farmacológico , Inmunoglobulinas Intravenosas/administración & dosificación , Extremidad Inferior , Dolor/tratamiento farmacológico , Dolor/etiología , Síndrome de Churg-Strauss/complicaciones , Síndrome de Churg-Strauss/diagnóstico , Resistencia a Medicamentos , Femenino , Granulomatosis con Poliangitis/complicaciones , Granulomatosis con Poliangitis/diagnóstico , Humanos , Infusiones Intravenosas , Metilprednisolona/administración & dosificación , Persona de Mediana Edad , Prednisolona/administración & dosificación , Quimioterapia por Pulso , Resultado del TratamientoAsunto(s)
Calcitriol/análogos & derivados , Fármacos Dermatológicos/efectos adversos , Pancreatitis/inducido químicamente , Psoriasis/tratamiento farmacológico , Enfermedad Aguda , Anciano , Calcitriol/administración & dosificación , Calcitriol/efectos adversos , Fármacos Dermatológicos/administración & dosificación , Humanos , Masculino , PomadasRESUMEN
Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous disease, associated with neoplasia, which has characteristic clinical, histological and immunological features. While respiratory epithelial involvement has been described in several cases, lesions in the colon epithelium have never been reported. We describe a 57-year-old Japanese woman with PNP who had many aphthae-like erosions on the colon epithelium, in addition to typical mucocutaneous PNP lesions. The intestinal erosions had histological features similar to those of PNP and linear deposition of complement, but not IgG, was observed along the colon epithelial basement membrane.