1.
Org Lett
; 18(19): 5074-5077, 2016 10 07.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27670608
RESUMEN
The synthesis of sterically hindered amines has been a significant challenge in organic chemistry. Herein, we report a modular, three-component coupling that constructs two carbon-nitrogen bonds including a sterically hindered Csp3-N bond using commercially available materials. This process uses an earth-abundant copper catalyst and mild reaction conditions, allowing access to a variety of complex aromatic amines.