RESUMEN
The mid-infrared range is an important spectrum range where materials exhibit a characteristic response corresponding to their molecular structure. A free-electron laser (FEL) is a promising candidate for a high-power light source with wavelength tunability to investigate the nonlinear response of materials. Although the self-amplification spontaneous emission (SASE) scheme is not usually adopted in the mid-infrared wavelength range, it may have advantages such as layout simplicity, the possibility of producing a single pulse, and scalability to a short-wavelength facility. To demonstrate the operation of a mid-infrared SASE FEL system in an energy recovery linac (ERL) layout, we constructed an SASE FEL setup in cERL, a test facility of the superconducting linac with the ERL configuration. Despite the adverse circumstance of space charge effects due to the given boundary condition of the facility, we successfully established the beam condition at the undulators and observed FEL emission at a wavelength of 20 µm. The results show that the layout of cERL has the potential for serving as a mid-infrared light source.
Asunto(s)
Enfermedad de Bowen/patología , Imiquimod/efectos adversos , Mastocitos/efectos de los fármacos , Psoriasis/inducido químicamente , Neoplasias Cutáneas/patología , Administración Cutánea , Anciano , Biopsia , Enfermedad de Bowen/tratamiento farmacológico , Epidermis/efectos de los fármacos , Epidermis/inmunología , Epidermis/patología , Glucocorticoides/administración & dosificación , Humanos , Imiquimod/administración & dosificación , Masculino , Mastocitos/inmunología , Psoriasis/tratamiento farmacológico , Psoriasis/inmunología , Psoriasis/patología , Escroto , Neoplasias Cutáneas/tratamiento farmacológico , Resultado del TratamientoAsunto(s)
Varicela/etiología , Síndrome de Hipersensibilidad a Medicamentos/etiología , Herpesvirus Humano 3/fisiología , Trasplante de Células Madre de Sangre Periférica/efectos adversos , Activación Viral , Femenino , Herpesvirus Humano 6/fisiología , Humanos , Persona de Mediana Edad , Mieloma Múltiple/terapiaAsunto(s)
Artritis Reumatoide/complicaciones , Pabellón Auricular/patología , Piodermia Gangrenosa/etiología , Anciano de 80 o más Años , Artritis Reumatoide/diagnóstico , Artritis Reumatoide/inmunología , Biopsia , Pabellón Auricular/efectos de los fármacos , Pabellón Auricular/inmunología , Femenino , Glucocorticoides/uso terapéutico , Humanos , Piodermia Gangrenosa/tratamiento farmacológico , Piodermia Gangrenosa/inmunología , Piodermia Gangrenosa/patología , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Cicatrización de Heridas/efectos de los fármacosAsunto(s)
Neoplasias de la Mama/diagnóstico , Dermatomiositis/sangre , Neoplasias Primarias Múltiples/diagnóstico , Síndromes Paraneoplásicos/sangre , Neoplasias Gástricas/diagnóstico , Cáncer Papilar Tiroideo/diagnóstico , Anciano , Neoplasias de la Mama/complicaciones , Dermatomiositis/etiología , Resultado Fatal , Femenino , Humanos , Neoplasias Primarias Múltiples/complicaciones , Proteínas Nucleares/inmunología , Síndromes Paraneoplásicos/etiología , Neoplasias Gástricas/complicaciones , Cáncer Papilar Tiroideo/complicaciones , Factores de Transcripción/inmunologíaRESUMEN
BACKGROUND: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of non-Hodgkin lymphoma that shows phenotypic features of cytotoxic T cells and preferentially involves subcutaneous tissue. SPTCL is believed to show an indolent clinical course, unless patients develop haemophagocytic syndrome. Various reported therapies include corticosteroids, immunosuppressive drugs, and chemotherapies. The use of chemotherapy as a first-line treatment remains controversial, and treatment approaches for SPTCL have not been established yet. OBJECTIVES: To investigate the clinicopathological features, treatment modalities, and outcomes of Japanese patients with SPTCL. MATERIALS & METHODS: We performed a literature review of Japanese cases of SPTCL. RESULTS: Twenty-two cases have been reported in the English and Japanese literature. Six cases were excluded due to a lack of sufficient clinical and immunohistological data, and treatment modalities and outcome were available in 16 cases. Clinical characteristics of the Japanese cases were generally similar to those of Western countries. Approximately half of the Japanese patients were treated initially with corticosteroids. Among them, more than half subsequently received chemotherapies due to a lack of response or recurrence of the disease. Overall, chemotherapy was used for approximately 80% of reported cases as a primary or secondary therapy. CONCLUSION: Our findings suggest that corticosteroids may be beneficial for some SPTCL patients, but most patients required chemotherapy during the course of their disease. Further investigations are needed to both establish appropriate treatment strategies for SPTCL and clarify predictive factors in order to identify patients who may benefit from corticosteroid therapy as a primary treatment.
Asunto(s)
Corticoesteroides/uso terapéutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Inmunosupresores/uso terapéutico , Linfoma Cutáneo de Células T/diagnóstico , Linfoma Cutáneo de Células T/tratamiento farmacológico , Corticoesteroides/administración & dosificación , Diagnóstico Diferencial , Humanos , Inmunosupresores/administración & dosificación , Japón , Linfoma Cutáneo de Células T/patología , Paniculitis/patologíaAsunto(s)
Alopecia/genética , Nevo con Halo/genética , Síndrome de Turner/genética , Vitíligo/genética , Alopecia/inmunología , Linfocitos T CD8-positivos/inmunología , Niño , Femenino , Humanos , Nevo con Halo/inmunología , Nevo con Halo/patología , Piel/citología , Piel/inmunología , Piel/patología , Síndrome de Turner/inmunología , Vitíligo/inmunología , Vitíligo/patologíaRESUMEN
Cutaneous lesions of sarcoidosis present with various manifestations including specific and non-specific cutaneous lesions. Ichthyosiform sarcoidosis is a rare form of cutaneous sarcoidosis, presenting with asymptomatic, adherent, polygonal scales, mainly appearing on the lower limbs. Ichthyosiform sarcoidosis has a predilection for dark-skinned races, and cases affecting Japanese patients have rarely been reported in English literature. We herein describe three Japanese cases of ichthyosiform sarcoidosis on the lower limbs. All of the patients were female, with an age range of 57-69 years old. Histologically, sarcoidal granulomas were located in the mid- to lower dermis. All cases had scar sarcoidosis on the knees. Furthermore, Case 1 presented with papular sarcoidosis on the back, and Case 3 presented with subcutaneous nodules on the buttock as well as erythema nodosum-like lesions on the lower legs. All patients had lung sarcoidosis, but ocular sarcoidosis was seen in only Case 2. Case 3 showed Heerfordt syndrome with facial nerve paralysis. Histological features showed that the granular layers were scarcely detected in the overlying epidermis; however, filaggrin expression was not decreased. Sarcoidal granulomas accumulated around the sweat glands in one case, whereas those features were not detected in the other two cases. In conclusion, ichthyosiform cutaneous sarcoidosis may be overlooked or misdiagnosed as xerotic dry skin which is frequently found in elderly people, and ichthyosiform cutaneous lesions may be more prevalent than previously estimated.