Multidimensional applications and potential health implications of nanocomposites.

This study reviews the concept, classifications, and techniques involved in the synthesis of nanocomposites. The environmental and health implications of nanoparticles and composite materials were detailed, as well as the applications of nanocomposites in water remediation, antibacterial application, and printed circuit boards. The study gave insights into the challenges of water pollution treatment and provided a broad list of nanocomposites that have been explored for water remediation. Moreover, the emergence of multi-drug resistance to many antibiotics has made current antibiotics inadequate in the treatment of disease. This has engineered the development of alternative strategies in the drug industries for the production of effective therapeutic agents, comprising nanocomposites with antibacterial agents. The new therapeutic agents known as nanoantibiotics are more efficient and have paved the way to handle the challenges of antibiotic resistance. In printed circuit boards, nanocomposites have shown promising applications because of their distinct mechanical, thermal, and electrical characteristics. The uniqueness of the write-up is that it provides a broad explanation of the concept, synthesis, application, toxicity, and harmful effects of nanocomposites. Thus, it will provide all-inclusive awareness to readers to identify research gaps and motivate researchers to synthesize novel nanocomposites for use in various fields.

Susceptibility of Multidrug-Resistant Bacteria, Isolated from Water and Plants in Nigeria, to Ceragenins.

The continuous emergence of multidrug resistant pathogens is a major global health concern. Although antimicrobial peptides (AMPs) have shown promise as a possible means of combatting multidrug resistant strains without readily engendering resistance, costs of production and targeting by proteases limit their utility. Ceragenins are non-peptide AMP mimics that overcome these shortcomings while retaining broad-spectrum antimicrobial activity. To further characterize the antibacterial activities of ceragenins, their activities against a collection of environmental isolates of bacteria were determined. These isolates were isolated in Nigeria from plants and water. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of selected ceragenins and currently available antimicrobials against these isolates were measured to determine resistance patterns. Using scanning electron microscopy (SEM), we examined the morphological changes in bacterial membranes following treatment with ceragenins. Finally, we investigated the effectiveness of ceragenins in inhibiting biofilm formation and destroying established biofilms. We found that, despite high resistance to many currently available antimicrobials, including colistin, environmental isolates in planktonic and biofilm forms remain susceptible to ceragenins. Additionally, SEM and confocal images of ceragenin-treated cells confirmed the effective antibacterial and antibiofilm activity of ceragenins.