Analysis of Prevalence and Trends in the Biopsy-Proven Native Kidney Diseases in Iranian Population: A 12-year Survey from a Referral Center.

Background & Objective: The prevalence of glomerular diseases, as the leading cause of chronic kidney disease, is increasing. Renal biopsy is still the gold standard for diagnosis of the most kidney disorders. Data on prevalence of the biopsy-proven kidney diseases in Iran is limited and none of the previously reported studies used electron microscopic (EM) evaluation for the diagnosis. This study was conducted to analyze the prevalence of biopsy-proven kidney diseases in a referral center in Iran. Methods: The reports of kidney biopsy samples from 2006 to 2018 referred to a pathology center, affiliated with Tehran University of Medical Sciences were reviewed. The prevalence of different disorders was assessed based on the clinical presentation in 3 age categories, including childhood, adulthood, and elderly. Results: Among 3455 samples, 2975 were analyzed after excluding transplant-related specimens, suboptimal specimens, and those with uncertain diagnoses. Nephrotic syndrome (NS) (39%) was the most common cause of biopsy followed by subnephrotic proteinuria (18%), hematuria in association with proteinuria (15%), renal failure (9%), isolated hematuria (6%), lupus (4%) and the other non-specific manifestations such as hypertetion or malaise (each one less than 2%). The most common diagnoses included membranous nephropathy (MGN) (17.9%), focal segmental glomerulosclerosis (FSGS) (15.9%), lupus nephritis (LN) (13.7%), minimal histopathological findings (unsampled FSGS versus Minimal Change Disease, 12.1%), Immunoglobulin-A (IgA) nephropathy (6.5%) and Alport syndrome (6.1%). MGN was the most frequent disease before 2013, but FSGS became more frequent after that. Conclusion: NS and proteinuria were the most indications for kidney biopsy. Although MGN was the most common disease, the prevalence of FSGS has been increasing in recent years and making it the most common disease after 2013. LN and IgA nephropathy are the most common causes of secondary and primary GN presenting with proteinuria and hematuria, respectively.

Spectrum and Distribution of Biopsy-proven Kidney Diseases: A 12-year Survey of a Single Center in Iran.

Data about the prevalence of biopsy-proven kidney diseases in Iran are rare, and none of the previous studies used electron microscopy for diagnosis. This study aimed to analyze the prevalence of biopsy-proven kidney diseases in Iran's primary referral center. To the best of our knowledge, this is the most extensive study carried out in Iran. Reports of kidney biopsy samples from patients referred to our center in 2007-2018 were reviewed for demographic data, clinical presentation, and final diagnosis. Statistical analyses were performed. Among the 3455 samples received, 2975 were analyzed. Nephrotic syndrome (39%) was the most common cause of biopsy, followed by subnephrotic proteinuria (18%), hematuria in association with proteinuria (15%), renal failure (9%), isolated hematuria (6%), and lupus nephritis (LN) (4%). The most common diagnoses were membranous glomerulonephritis (17.9%), focal segmental glomerulosclerosis (FSGS) (15.9%), LN (13.7%), minimal histopathological findings (unsampled FSGS vs. minimal change disease, 12.1%), Immunoglobin A nephropathy (IgAN) (6.5%) and Alport syndrome (6.1%). NS and proteinuria were the most common indications for a kidney biopsy. IgAN and LN were the most common causes of primary and secondary glomerulonephritis, presenting with hematuria and proteinuria, respectively. Although membranous glomerulonephritis was the most common disease, it has been replaced by FSGS in recent years.

Quality assessment of case reports in high-impact urology journals using SCARE guideline.

BACKGROUND AND AIMS: The usefulness of case reports is dependent on the complete, consistent, and rigorous reporting of these cases. In order to provide a standard guideline for reporting surgical case reports, the SCARE (Surgical CAse REport) guidelines were developed in 2016. The present study evaluated the completeness and transparency of published case reports in high-impact urology journals based on the SCARE guideline. METHODS: This cross-sectional study was performed on 100 case reports published in Urology, Urology Journal, BMC Urology, and Urology Case Reports journal. Two independent reviewers performed the scoring using the last version of SCARE statement. Each of the 34 items of SCARE guideline were classified as "yes" if the item was reported in the case report text. The SCARE items were classified as "no" when the authors of case reports had not reported that item or could not tell something about reporting the item. Completeness of reporting (COR) score was calculated for each case report. COR score (%) is defined as ["yes" answers/("yes" answers + "no" answers)] × 100 for each case report. RESULTS: The mean COR score for all the assessed case reports was 49%, ranging from 21% to 79%. Topics with the highest mean COR score were introduction (77% ± 42%), additional information (75% ± 43%), patient information (65% ± 19%), and abstract (66% ± 24%). In contrast, topics with the lowest mean COR were patient perspective (1% ± 10%) and keywords (3% ± 17%). CONCLUSION: The present study showed that case reports published in urology journals suffer from insufficient reporting. SCARE or CARE guidelines can provide a framework for assessing the reporting quality of case reports before publication. Nevertheless, further studies are highly recommended to better evaluate the efficacy of these guidelines' endorsement on the quality of case reports published in urology journals.

Loss of vision after transurethral resection of prostate: A case report.

The overall complication rate of Transurethral resection of prostate (TURP) is about 11.1%. Amongst all complications, ocular complications are one of the rarest. In this paper, we present a case of vision loss due to paradoxical embolism as a rare complication following TURP. Ocular complications are very rare in urological surgeries but can happen due to paradoxical embolism following patent foramen ovale. Therefore, we recommend the early diagnosis and treatment of PFO prior to this type of surgery.