RESUMEN
Clinical information retrieval (IR) plays a vital role in modern healthcare by facilitating efficient access and analysis of medical literature for clinicians and researchers. This scoping review aims to offer a comprehensive overview of the current state of clinical IR research and identify gaps and potential opportunities for future studies in this field. The main objective was to assess and analyze the existing literature on clinical IR, focusing on the methods, techniques, and tools employed for effective retrieval and analysis of medical information. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted an extensive search across databases such as Ovid Embase, Ovid Medline, Scopus, ACM Digital Library, IEEE Xplore, and Web of Science, covering publications from January 1, 2010, to January 4, 2023. The rigorous screening process led to the inclusion of 184 papers in our review. Our findings provide a detailed analysis of the clinical IR research landscape, covering aspects like publication trends, data sources, methodologies, evaluation metrics, and applications. The review identifies key research gaps in clinical IR methods such as indexing, ranking, and query expansion, offering insights and opportunities for future studies in clinical IR, thus serving as a guiding framework for upcoming research efforts in this rapidly evolving field. The study also underscores an imperative for innovative research on advanced clinical IR systems capable of fast semantic vector search and adoption of neural IR techniques for effective retrieval of information from unstructured electronic health records (EHRs). Supplementary Information: The online version contains supplementary material available at 10.1007/s41666-024-00159-4.
RESUMEN
Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest. Senescent cells are characterized by their senescence-associated secretory phenotype that overproduces inflammatory and catabolic factors that hamper normal tissue homeostasis. Chronic accumulation of senescent cells is thought to be associated with intervertebral disc degeneration (IDD) in an aging population. This IDD is one of the largest age-dependent chronic disorders, often associated with neurological dysfunctions such as, low back pain, radiculopathy, and myelopathy. Senescent cells (SnCs) increase in number in the aged, degenerated discs, and have a causative role in driving age-related IDD. This review summarizes current evidence supporting the role of CS on onset and progression of age-related IDD. The discussion includes molecular pathways involved in CS such as p53-p21CIP1, p16INK4a, NF-κB, and MAPK, and the potential therapeutic value of targeting these pathways. We propose several mechanisms of CS in IDD including mechanical stress, oxidative stress, genotoxic stress, nutritional deprivation, and inflammatory stress. There are still large knowledge gaps in disc CS research, an understanding of which will provide opportunities to develop therapeutic interventions to treat age-related IDD.
