The Study of the Distribution of Electrical and Magnetic Properties over the Conductor Cross-Section Using Magnetoimpedance Tomography: Modeling and Experiment.

A description of the method of magnetoimpedance tomography is presented. This method is based on the analysis of the frequency dependences of the impedance obtained in magnetic fields of various strengths. It allows one to determine the distribution of electrical and magnetic properties over the cross-section of the conductor, as well as their dependence on the magnetic field. The article proposes a specific approach to the implementation of the magnetoimpedance tomography method based on computer modeling by the finite element method. The results of this method are presented for composite Cu98Be2/Fe20Co6Ni74 wires of the "highly conductive core-magnetically soft coating" type and amorphous rapidly quenched Co66Fe4Nb2.5Si12.5B15 wires.

Magnetoimpedance and Stress-Impedance Effects in Amorphous CoFeSiB Ribbons at Elevated Temperatures.

The temperature dependencies of magnetoimpedance (MI) and stress impedance (SI) were analyzed both in the as-quenched soft magnetic Co68.5Fe4Si15B12.5 ribbons and after their heat treatment at 425 K for 8 h. It was found that MI shows weak changes under the influence of mechanical stresses in the temperature range of 295-325 K and SI does not exceed 10%. At higher temperatures, the MI changes significantly under the influence of mechanical stresses, and SI variations reach 30%. Changes in the magnetoelastic properties for the different temperatures were taken into consideration for the discussion of the observed MI and SI responses. The solutions for the problem of thermal stability of the magnetic sensors working on the principles of MI or SI were discussed taking into account the joint contributions of the temperature and the applied mechanical stresses.

Disparity between Inter-Patient Molecular Heterogeneity and Repertoires of Target Drugs Used for Different Types of Cancer in Clinical Oncology.

Inter-patient molecular heterogeneity is the major declared driver of an expanding variety of anticancer drugs and personalizing their prescriptions. Here, we compared interpatient molecular heterogeneities of tumors and repertoires of drugs or their molecular targets currently in use in clinical oncology. We estimated molecular heterogeneity using genomic (whole exome sequencing) and transcriptomic (RNA sequencing) data for 4890 tumors taken from The Cancer Genome Atlas database. For thirteen major cancer types, we compared heterogeneities at the levels of mutations and gene expression with the repertoires of targeted therapeutics and their molecular targets accepted by the current guidelines in oncology. Totally, 85 drugs were investigated, collectively covering 82 individual molecular targets. For the first time, we showed that the repertoires of molecular targets of accepted drugs did not correlate with molecular heterogeneities of different cancer types. On the other hand, we found that the clinical recommendations for the available cancer drugs were strongly congruent with the gene expression but not gene mutation patterns. We detected the best match among the drugs usage recommendations and molecular patterns for the kidney, stomach, bladder, ovarian and endometrial cancers. In contrast, brain tumors, prostate and colorectal cancers showed the lowest match. These findings provide a theoretical basis for reconsidering usage of targeted therapeutics and intensifying drug repurposing efforts.

Permalloy-Based Thin Film Structures: Magnetic Properties and the Giant Magnetoimpedance Effect in the Temperature Range Important for Biomedical Applications.

Permalloy-based thin film structures are excellent materials for sensor applications. Temperature dependencies of the magnetic properties and giant magneto-impedance (GMI) were studied for Fe19Ni81-based multilayered structures obtained by the ion-plasma sputtering technique. Selected temperature interval of 25 °C to 50 °C corresponds to the temperature range of functionality of many devices, including magnetic biosensors. A (Cu/FeNi)5/Cu/(Cu/FeNi)5 multilayered structure with well-defined traverse magnetic anisotropy showed an increase in the GMI ratio for the total impedance and its real part with temperature increased. The maximum of the GMI of the total impedance ratio ΔZ/Z = 56% was observed at a frequency of 80 MHz, with a sensitivity of 18%/Oe, and the maximum GMI of the real part ΔR/R = 170% at a frequency of 10 MHz, with a sensitivity of 46%/Oe. As the magnetization and direct current electrical resistance vary very little with the temperature, the most probable mechanism of the unexpected increase of the GMI sensitivity is the stress relaxation mechanism associated with magnetoelastic anisotropy.