Malignancy pattern analysis of breast ultrasound images using clinical features and a graph convolutional network.

Objective: Early diagnosis of breast cancer can lead to effective treatment, possibly increase long-term survival rates, and improve quality of life. The objective of this study is to present an automated analysis and classification system for breast cancer using clinical markers such as tumor shape, orientation, margin, and surrounding tissue. The novelty and uniqueness of the study lie in the approach of considering medical features based on the diagnosis of radiologists. Methods: Using clinical markers, a graph is generated where each feature is represented by a node, and the connection between them is represented by an edge which is derived through Pearson's correlation method. A graph convolutional network (GCN) model is proposed to classify breast tumors into benign and malignant, using the graph data. Several statistical tests are performed to assess the importance of the proposed features. The performance of the proposed GCN model is improved by experimenting with different layer configurations and hyper-parameter settings. Results: Results show that the proposed model has a 98.73% test accuracy. The performance of the model is compared with a graph attention network, a one-dimensional convolutional neural network, and five transfer learning models, ten machine learning models, and three ensemble learning models. The performance of the model was further assessed with three supplementary breast cancer ultrasound image datasets, where the accuracies are 91.03%, 94.37%, and 89.62% for Dataset A, Dataset B, and Dataset C (combining Dataset A and Dataset B) respectively. Overfitting issues are assessed through k-fold cross-validation. Conclusion: Several variants are utilized to present a more rigorous and fair evaluation of our work, especially the importance of extracting clinically relevant features. Moreover, a GCN model using graph data can be a promising solution for an automated feature-based breast image classification system.

Improving the Automated Diagnosis of Breast Cancer with Mesh Reconstruction of Ultrasound Images Incorporating 3D Mesh Features and a Graph Attention Network.

This study proposes a novel approach for breast tumor classification from ultrasound images into benign and malignant by converting the region of interest (ROI) of a 2D ultrasound image into a 3D representation using the point-e system, allowing for in-depth analysis of underlying characteristics. Instead of relying solely on 2D imaging features, this method extracts 3D mesh features that describe tumor patterns more precisely. Ten informative and medically relevant mesh features are extracted and assessed with two feature selection techniques. Additionally, a feature pattern analysis has been conducted to determine the feature's significance. A feature table with dimensions of 445 × 12 is generated and a graph is constructed, considering the rows as nodes and the relationships among the nodes as edges. The Spearman correlation coefficient method is employed to identify edges between the strongly connected nodes (with a correlation score greater than or equal to 0.7), resulting in a graph containing 56,054 edges and 445 nodes. A graph attention network (GAT) is proposed for the classification task and the model is optimized with an ablation study, resulting in the highest accuracy of 99.34%. The performance of the proposed model is compared with ten machine learning (ML) models and one-dimensional convolutional neural network where the test accuracy of these models ranges from 73 to 91%. Our novel 3D mesh-based approach, coupled with the GAT, yields promising performance for breast tumor classification, outperforming traditional models, and has the potential to reduce time and effort of radiologists providing a reliable diagnostic system.

An Automated Decision Support System to Analyze Malignancy Patterns of Breast Masses Employing Medically Relevant Features of Ultrasound Images.

An automated computer-aided approach might aid radiologists in diagnosing breast cancer at a primary stage. This study proposes a novel decision support system to classify breast tumors into benign and malignant based on clinically important features, using ultrasound images. Nine handcrafted features, which align with the clinical markers used by radiologists, are extracted from the region of interest (ROI) of ultrasound images. To validate that these elected clinical markers have a significant impact on predicting the benign and malignant classes, ten machine learning (ML) models are experimented with resulting in test accuracies in the range of 96 to 99%. In addition, four feature selection techniques are explored where two features are eliminated according to the feature ranking score of each feature selection method. The Random Forest classifier is trained with the resultant four feature sets. Results indicate that even when eliminating only two features, the performance of the model is reduced for each feature selection technique. These experiments validate the efficiency and effectiveness of the clinically important features. To develop the decision support system, a probability density function (PDF) graph is generated for each feature in order to find a threshold range to distinguish benign and malignant tumors. Based on the threshold range of particular features, a decision support system is developed in such a way that if at least eight out of nine features are within the threshold range, the image will be denoted as true predicted. With this algorithm, a test accuracy of 99.38% and an F1 Score of 99.05% is achieved, which means that our decision support system outperforms all the previously trained ML models. Moreover, after calculating individual class-based test accuracies, for the benign class, a test accuracy of 99.31% has been attained where only three benign instances are misclassified out of 437 instances, and for the malignant class, a test accuracy of 99.52% has been attained where only one malignant instance is misclassified out of 210 instances. This system is robust, time-effective, and reliable as the radiologists' criteria are followed and may aid specialists in making a diagnosis.

The status of implemented climate smart agriculture practices preferred by farmers of haor area as a climate resilient approach.

Bangladesh's Haor regions are famous for their natural resources and are unable to escape climate vulnerability. Triggered by climate vulnerabilities farmers are heading towards climate-resilient approaches. Hence, research was done in the haor area of Sunamganj district to analyze the status of adopted Climate-Smart Agriculture (CSA) techniques in Chhatak, Sunamganj, and Jagannathpur which are prone to severe flooding and climate conditions. Around 450 farmers were randomly selected and CSA adopters were contacted. A structured questionnaire was prepared with open-ended and closed-ended questions. The final questionnaire contained demographic questions and a list of adopted cropland and homestead CSA practices, and the survey proceeded with 115 finalized CSA adopters. MS Excel and SPSS were used to analyze the data. The data were expressed using frequency, percent, mean, and standard deviation. A t-test, analysis of variance, multiple linear regression, Pearson correlation, boxplot, and normal P-P plots were employed to test data normality. The analysis revealed that 30 CSA practices were identified to be practiced in cropland where major preferences were found for appropriate seed storage (100%), USG application (100%), IPM (98%), and good quality seed (95%) in cropland, whereas agroforestry (71%), organic fertilizer application (63%), perching (63%) and IPM (59%) were major CSA practices among the 18 identified practices in homesteads. The adoption level of CSA practices was found in the score category of 11-23 for cropland (90%) and up to 10 for homestead (68%). The results showed that the adoption status of CSA practices was inefficient for quick flood occurrence. CSA practices are not applied enough in haor areas' homesteads due to lack of knowledge, information access, and technical and financial resources. Thus, CSA should be implemented which necessitates working on barriers restricting CSA adoption through strengthening the infrastructure of technologies, supportive policies, and institutional framework.

Graph neural network-based breast cancer diagnosis using ultrasound images with optimized graph construction integrating the medically significant features.

PURPOSE: An automated computerized approach can aid radiologists in the early diagnosis of breast cancer. In this study, a novel method is proposed for classifying breast tumors into benign and malignant, based on the ultrasound images through a Graph Neural Network (GNN) model utilizing clinically significant features. METHOD: Ten informative features are extracted from the region of interest (ROI), based on the radiologists' diagnosis markers. The significance of the features is evaluated using density plot and T test statistical analysis method. A feature table is generated where each row represents individual image, considered as node, and the edges between the nodes are denoted by calculating the Spearman correlation coefficient. A graph dataset is generated and fed into the GNN model. The model is configured through ablation study and Bayesian optimization. The optimized model is then evaluated with different correlation thresholds for getting the highest performance with a shallow graph. The performance consistency is validated with k-fold cross validation. The impact of utilizing ROIs and handcrafted features for breast tumor classification is evaluated by comparing the model's performance with Histogram of Oriented Gradients (HOG) descriptor features from the entire ultrasound image. Lastly, a clustering-based analysis is performed to generate a new filtered graph, considering weak and strong relationships of the nodes, based on the similarities. RESULTS: The results indicate that with a threshold value of 0.95, the GNN model achieves the highest test accuracy of 99.48%, precision and recall of 100%, and F1 score of 99.28%, reducing the number of edges by 85.5%. The GNN model's performance is 86.91%, considering no threshold value for the graph generated from HOG descriptor features. Different threshold values for the Spearman's correlation score are experimented with and the performance is compared. No significant differences are observed between the previous graph and the filtered graph. CONCLUSION: The proposed approach might aid the radiologists in effective diagnosing and learning tumor pattern of breast cancer.

Deep learning-based analysis of COVID-19 X-ray images: Incorporating clinical significance and assessing misinterpretation.

COVID-19, pneumonia, and tuberculosis have had a significant effect on recent global health. Since 2019, COVID-19 has been a major factor underlying the increase in respiratory-related terminal illness. Early-stage interpretation and identification of these diseases from X-ray images is essential to aid medical specialists in diagnosis. In this study, (COV-X-net19) a convolutional neural network model is developed and customized with a soft attention mechanism to classify lung diseases into four classes: normal, COVID-19, pneumonia, and tuberculosis using chest X-ray images. Image preprocessing is carried out by adjusting optimal parameters to preprocess the images before undertaking training of the classification models. Moreover, the proposed model is optimized by experimenting with different architectural structures and hyperparameters to further boost performance. The performance of the proposed model is compared with eight state-of-the-art transfer learning models for a comparative evaluation. Results suggest that the COV-X-net19 outperforms other models with a testing accuracy of 95.19%, precision of 96.49% and F1-score of 95.13%. Another novel approach of this study is to find out the probable reason behind image misclassification by analyzing the handcrafted imaging features with statistical evaluation. A statistical analysis known as analysis of variance test is performed, to identify at which point the model can identify a class accurately, and at which point the model cannot identify the class. The potential features responsible for the misclassification are also found. Moreover, Random Forest Feature importance technique and Minimum Redundancy Maximum Relevance technique are also explored. The methods and findings of this study can benefit in the clinical perspective in early detection and enable a better understanding of the cause of misclassification.

Automated breast tumor ultrasound image segmentation with hybrid UNet and classification using fine-tuned CNN model.

Introduction: Breast cancer stands as the second most deadly form of cancer among women worldwide. Early diagnosis and treatment can significantly mitigate mortality rates. Purpose: The study aims to classify breast ultrasound images into benign and malignant tumors. This approach involves segmenting the breast's region of interest (ROI) employing an optimized UNet architecture and classifying the ROIs through an optimized shallow CNN model utilizing an ablation study. Method: Several image processing techniques are utilized to improve image quality by removing text, artifacts, and speckle noise, and statistical analysis is done to check the enhanced image quality is satisfactory. With the processed dataset, the segmentation of breast tumor ROI is carried out, optimizing the UNet model through an ablation study where the architectural configuration and hyperparameters are altered. After obtaining the tumor ROIs from the fine-tuned UNet model (RKO-UNet), an optimized CNN model is employed to classify the tumor into benign and malignant classes. To enhance the CNN model's performance, an ablation study is conducted, coupled with the integration of an attention unit. The model's performance is further assessed by classifying breast cancer with mammogram images. Result: The proposed classification model (RKONet-13) results in an accuracy of 98.41 %. The performance of the proposed model is further compared with five transfer learning models for both pre-segmented and post-segmented datasets. K-fold cross-validation is done to assess the proposed RKONet-13 model's performance stability. Furthermore, the performance of the proposed model is compared with previous literature, where the proposed model outperforms existing methods, demonstrating its effectiveness in breast cancer diagnosis. Lastly, the model demonstrates its robustness for breast cancer classification, delivering an exceptional performance of 96.21 % on a mammogram dataset. Conclusion: The efficacy of this study relies on image pre-processing, segmentation with hybrid attention UNet, and classification with fine-tuned robust CNN model. This comprehensive approach aims to determine an effective technique for detecting breast cancer within ultrasound images.

A novel Data and Model Centric artificial intelligence based approach in developing high-performance Named Entity Recognition for Bengali Language.

Named Entity Recognition (NER) plays a significant role in enhancing the performance of all types of domain specific applications in Natural Language Processing (NLP). According to the type of application, the goal of NER is to identify target entities based on the context of other existing entities in a sentence. Numerous architectures have demonstrated good performance for high-resource languages such as English and Chinese NER. However, currently existing NER models for Bengali could not achieve reliable accuracy due to morphological richness of Bengali and limited availability of resources. This work integrates both Data and Model Centric AI concepts to achieve a state-of-the-art performance. A unique dataset was created for this study demonstrating the impact of a good quality dataset on accuracy. We proposed a method for developing a high quality NER dataset for any language. We have used our dataset to evaluate the performance of various Deep Learning models. A hybrid model performed with the exact match F1 score of 87.50%, partial match F1 score of 92.31%, and micro F1 score of 98.32%. Our proposed model reduces the need for feature engineering and utilizes minimal resources.

An Automated Broncho-Arterial (BA) Pair Segmentation Process and Assessment of BA Ratios in Children with Bronchiectasis Using Lung HRCT Scans: A Pilot Study.

Bronchiectasis in children can progress to a severe lung condition if not diagnosed and treated early. The radiological diagnostic criteria for the diagnosis of bronchiectasis is an increased broncho-arterial (BA) ratio. From high-resolution computed tomography (HRCT) scans, the BA pairs must be detected first to derive the BA ratio. This study aims to identify potential BA pairs from HRCT scans of children undertaken to evaluate suppurative lung disease through an automated approach. After segmenting the lung regions, the HRCT scans are cleaned using a histogram analysis-based approach followed by a potential arteries identification process comprising four conditions based on imaging features. Potential arteries and their connected components are extracted, and potential bronchi are identified. Finally, the coordinates of potential arteries and potential bronchi are matched as the last step of BA pairs extraction. A total of 8-50 BA pairs are detected for each patient. Additionally, the area and several diameters of the bronchi and arteries are measured, and BA ratios based on these are calculated. Through this approach, the BA pairs of a CT scan datasets are detected and utilizing a deep learning model, a high classification test accuracy of 98.53% is achieved, validating the robustness of the proposed BA detection approach. The results show that visible BA pairs can be identified and segmented automatically, and the BA ratio calculated may help diagnose bronchiectasis with less effort and time.

Automated Detection of Broncho-Arterial Pairs Using CT Scans Employing Different Approaches to Classify Lung Diseases.

Current research indicates that for the identification of lung disorders, comprising pneumonia and COVID-19, structural distortions of bronchi and arteries (BA) should be taken into account. CT scans are an effective modality to detect lung anomalies. However, anomalies in bronchi and arteries can be difficult to detect. Therefore, in this study, alterations of bronchi and arteries are considered in the classification of lung diseases. Four approaches to highlight these are introduced: (a) a Hessian-based approach, (b) a region-growing algorithm, (c) a clustering-based approach, and (d) a color-coding-based approach. Prior to this, the lungs are segmented, employing several image preprocessing algorithms. The utilized COVID-19 Lung CT scan dataset contains three classes named Non-COVID, COVID, and community-acquired pneumonia, having 6983, 7593, and 2618 samples, respectively. To classify the CT scans into three classes, two deep learning architectures, (a) a convolutional neural network (CNN) and (b) a CNN with long short-term memory (LSTM) and an attention mechanism, are considered. Both these models are trained with the four datasets achieved from the four approaches. Results show that the CNN model achieved test accuracies of 88.52%, 87.14%, 92.36%, and 95.84% for the Hessian, the region-growing, the color-coding, and the clustering-based approaches, respectively. The CNN with LSTM and an attention mechanism model results in an increase in overall accuracy for all approaches with an 89.61%, 88.28%, 94.61%, and 97.12% test accuracy for the Hessian, region-growing, color-coding, and clustering-based approaches, respectively. To assess overfitting, the accuracy and loss curves and k-fold cross-validation technique are employed. The Hessian-based and region-growing algorithm-based approaches produced nearly equivalent outcomes. Our proposed method outperforms state-of-the-art studies, indicating that it may be worthwhile to pay more attention to BA features in lung disease classification based on CT images.

An Effective Ensemble Machine Learning Approach to Classify Breast Cancer Based on Feature Selection and Lesion Segmentation Using Preprocessed Mammograms.

Background: Breast cancer, behind skin cancer, is the second most frequent malignancy among women, initiated by an unregulated cell division in breast tissues. Although early mammogram screening and treatment result in decreased mortality, differentiating cancer cells from surrounding tissues are often fallible, resulting in fallacious diagnosis. Method: The mammography dataset is used to categorize breast cancer into four classes with low computational complexity, introducing a feature extraction-based approach with machine learning (ML) algorithms. After artefact removal and the preprocessing of the mammograms, the dataset is augmented with seven augmentation techniques. The region of interest (ROI) is extracted by employing several algorithms including a dynamic thresholding method. Sixteen geometrical features are extracted from the ROI while eleven ML algorithms are investigated with these features. Three ensemble models are generated from these ML models employing the stacking method where the first ensemble model is built by stacking ML models with an accuracy of over 90% and the accuracy thresholds for generating the rest of the ensemble models are >95% and >96. Five feature selection methods with fourteen configurations are applied to notch up the performance. Results: The Random Forest Importance algorithm, with a threshold of 0.045, produces 10 features that acquired the highest performance with 98.05% test accuracy by stacking Random Forest and XGB classifier, having a higher than >96% accuracy. Furthermore, with K-fold cross-validation, consistent performance is observed across all K values ranging from 3−30. Moreover, the proposed strategy combining image processing, feature extraction and ML has a proven high accuracy in classifying breast cancer.

A Robust Framework Combining Image Processing and Deep Learning Hybrid Model to Classify Cardiovascular Diseases Using a Limited Number of Paper-Based Complex ECG Images.

Heart disease can be life-threatening if not detected and treated at an early stage. The electrocardiogram (ECG) plays a vital role in classifying cardiovascular diseases, and often physicians and medical researchers examine paper-based ECG images for cardiac diagnosis. An automated heart disease prediction system might help to classify heart diseases accurately at an early stage. This study aims to classify cardiac diseases into five classes with paper-based ECG images using a deep learning approach with the highest possible accuracy and the lowest possible time complexity. This research consists of two approaches. In the first approach, five deep learning models, InceptionV3, ResNet50, MobileNetV2, VGG19, and DenseNet201, are employed. In the second approach, an integrated deep learning model (InRes-106) is introduced, combining InceptionV3 and ResNet50. This model is developed as a deep convolutional neural network capable of extracting hidden and high-level features from images. An ablation study is conducted on the proposed model altering several components and hyperparameters, improving the performance even further. Before training the model, several image pre-processing techniques are employed to remove artifacts and enhance the image quality. Our proposed hybrid InRes-106 model performed best with a testing accuracy of 98.34%. The InceptionV3 model acquired a testing accuracy of 90.56%, the ResNet50 89.63%, the DenseNet201 88.94%, the VGG19 87.87%, and the MobileNetV2 achieved 80.56% testing accuracy. The model is trained with a k-fold cross-validation technique with different k values to evaluate the robustness further. Although the dataset contains a limited number of complex ECG images, our proposed approach, based on various image pre-processing techniques, model fine-tuning, and ablation studies, can effectively diagnose cardiac diseases.

MNet-10: A robust shallow convolutional neural network model performing ablation study on medical images assessing the effectiveness of applying optimal data augmentation technique.

Interpretation of medical images with a computer-aided diagnosis (CAD) system is arduous because of the complex structure of cancerous lesions in different imaging modalities, high degree of resemblance between inter-classes, presence of dissimilar characteristics in intra-classes, scarcity of medical data, and presence of artifacts and noises. In this study, these challenges are addressed by developing a shallow convolutional neural network (CNN) model with optimal configuration performing ablation study by altering layer structure and hyper-parameters and utilizing a suitable augmentation technique. Eight medical datasets with different modalities are investigated where the proposed model, named MNet-10, with low computational complexity is able to yield optimal performance across all datasets. The impact of photometric and geometric augmentation techniques on different datasets is also evaluated. We selected the mammogram dataset to proceed with the ablation study for being one of the most challenging imaging modalities. Before generating the model, the dataset is augmented using the two approaches. A base CNN model is constructed first and applied to both the augmented and non-augmented mammogram datasets where the highest accuracy is obtained with the photometric dataset. Therefore, the architecture and hyper-parameters of the model are determined by performing an ablation study on the base model using the mammogram photometric dataset. Afterward, the robustness of the network and the impact of different augmentation techniques are assessed by training the model with the rest of the seven datasets. We obtain a test accuracy of 97.34% on the mammogram, 98.43% on the skin cancer, 99.54% on the brain tumor magnetic resonance imaging (MRI), 97.29% on the COVID chest X-ray, 96.31% on the tympanic membrane, 99.82% on the chest computed tomography (CT) scan, and 98.75% on the breast cancer ultrasound datasets by photometric augmentation and 96.76% on the breast cancer microscopic biopsy dataset by geometric augmentation. Moreover, some elastic deformation augmentation methods are explored with the proposed model using all the datasets to evaluate their effectiveness. Finally, VGG16, InceptionV3, and ResNet50 were trained on the best-performing augmented datasets, and their performance consistency was compared with that of the MNet-10 model. The findings may aid future researchers in medical data analysis involving ablation studies and augmentation techniques.

A shallow deep learning approach to classify skin cancer using down-scaling method to minimize time and space complexity.

The complex feature characteristics and low contrast of cancer lesions, a high degree of inter-class resemblance between malignant and benign lesions, and the presence of various artifacts including hairs make automated melanoma recognition in dermoscopy images quite challenging. To date, various computer-aided solutions have been proposed to identify and classify skin cancer. In this paper, a deep learning model with a shallow architecture is proposed to classify the lesions into benign and malignant. To achieve effective training while limiting overfitting problems due to limited training data, image preprocessing and data augmentation processes are introduced. After this, the 'box blur' down-scaling method is employed, which adds efficiency to our study by reducing the overall training time and space complexity significantly. Our proposed shallow convolutional neural network (SCNN_12) model is trained and evaluated on the Kaggle skin cancer data ISIC archive which was augmented to 16485 images by implementing different augmentation techniques. The model was able to achieve an accuracy of 98.87% with optimizer Adam and a learning rate of 0.001. In this regard, parameter and hyper-parameters of the model are determined by performing ablation studies. To assert no occurrence of overfitting, experiments are carried out exploring k-fold cross-validation and different dataset split ratios. Furthermore, to affirm the robustness the model is evaluated on noisy data to examine the performance when the image quality gets corrupted.This research corroborates that effective training for medical image analysis, addressing training time and space complexity, is possible even with a lightweighted network using a limited amount of training data.

BreastNet18: A High Accuracy Fine-Tuned VGG16 Model Evaluated Using Ablation Study for Diagnosing Breast Cancer from Enhanced Mammography Images.

BACKGROUND: Identification and treatment of breast cancer at an early stage can reduce mortality. Currently, mammography is the most widely used effective imaging technique in breast cancer detection. However, an erroneous mammogram based interpretation may result in false diagnosis rate, as distinguishing cancerous masses from adjacent tissue is often complex and error-prone. METHODS: Six pre-trained and fine-tuned deep CNN architectures: VGG16, VGG19, MobileNetV2, ResNet50, DenseNet201, and InceptionV3 are evaluated to determine which model yields the best performance. We propose a BreastNet18 model using VGG16 as foundational base, since VGG16 performs with the highest accuracy. An ablation study is performed on BreastNet18, to evaluate its robustness and achieve the highest possible accuracy. Various image processing techniques with suitable parameter values are employed to remove artefacts and increase the image quality. A total dataset of 1442 preprocessed mammograms was augmented using seven augmentation techniques, resulting in a dataset of 11,536 images. To investigate possible overfitting issues, a k-fold cross validation is carried out. The model was then tested on noisy mammograms to evaluate its robustness. Results were compared with previous studies. RESULTS: Proposed BreastNet18 model performed best with a training accuracy of 96.72%, a validating accuracy of 97.91%, and a test accuracy of 98.02%. In contrast to this, VGGNet19 yielded test accuracy of 96.24%, MobileNetV2 77.84%, ResNet50 79.98%, DenseNet201 86.92%, and InceptionV3 76.87%. CONCLUSIONS: Our proposed approach based on image processing, transfer learning, fine-tuning, and ablation study has demonstrated a high correct breast cancer classification while dealing with a limited number of complex medical images.