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Bioorg Med Chem Lett
; 19(8): 2333-7, 2009 Apr 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19286381
RESUMEN
2,7-Diamino-thiazolo[4,5-d]pyrimidine analogues were synthesized as novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. Representative compounds showed potent and selective EGFR inhibitory activities and inhibited in vitro cellular proliferation in EGFR-overexpressing human tumor cells. The synthesis and preliminary biological, physical, and pharmacokinetic evaluation of these thiazolopyrimidine compounds are reported.