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1.
J Clin Endocrinol Metab ; 97(10): 3515-21, 2012 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22865896

RESUMEN

CONTEXT: Patients with amiodarone-induced thyrotoxicosis (AIT) and left ventricular (LV) systolic dysfunction have a high mortality rate. Usually, medical therapy is the first choice for AIT patients, whereas the role of the thyroidectomy is unsettled. OBJECTIVE: The objective of the study was to evaluate the effect of a total thyroidectomy on cardiac function and survival of AIT patients with severe LV systolic dysfunction. DESIGN: This was a retrospective cohort study. SETTINGS: The study was conducted at a tertiary university center. PATIENTS: All AIT patients (n=24; nine patients with type 1 AIT, 15 patients with type 2 AIT) referred to the Department of Endocrinology and submitted to a total thyroidectomy at the Department of Surgery, both at the University of Pisa, during the years 1997-2010. INTERVENTION: The intervention was a total thyroidectomy. MAIN OUTCOME MEASURE: LV ejection fraction (EF) after the thyroidectomy and survival in December 2011 were measured. RESULTS: All enrolled patients had previously undergone to medical treatment for AIT, as appropriate, without achieving euthyroidism. Patients with moderate to severe LV systolic dysfunction (EF<40%, group 1, n=9) or with mild systolic dysfunction (40%≤EF≤50%, group 2, n=5) were compared with patients with normal systolic function (EF>50%, group 3, n=10). Two months after thyroidectomy, under levothyroxine replacement therapy, LVEF improved in patients with LV systolic dysfunction, particularly in those of group 1, in whom it increased from 28.2±7.2 to 38.3±6% (P=0.007). On the contrary, LVEF did not significantly change in group 3 (from 57.1±3.0 to 59.8±6.6%, P=0.242). The mean follow-up was 67±42 months. No death occurred during and 2 months after surgery. One death occurred in one patient of group 1, 30 months after the thyroidectomy, due to acute myocardial infarction. No patient had relevant complications of thyroidectomy. CONCLUSIONS: Total thyroidectomy, by rapidly restoring euthyroidism, may improve cardiac function and reduce the risk of mortality in AIT patients with severe LV dysfunction.


Asunto(s)
Amiodarona/efectos adversos , Tiroidectomía/métodos , Tirotoxicosis , Disfunción Ventricular Izquierda/mortalidad , Anciano , Antiarrítmicos/efectos adversos , Femenino , Cardiopatías/tratamiento farmacológico , Cardiopatías/mortalidad , Humanos , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/mortalidad , Estudios Retrospectivos , Factores de Riesgo , Índice de Severidad de la Enfermedad , Volumen Sistólico , Sístole , Tiroidectomía/mortalidad , Tirotoxicosis/inducido químicamente , Tirotoxicosis/mortalidad , Tirotoxicosis/cirugía , Vasodilatadores/efectos adversos
2.
Surg Endosc ; 26(3): 818-22, 2012 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-22038162

RESUMEN

BACKGROUND: The first report of minimally invasive video-assisted thyroidectomy (MIVAT) was published in 1999, and the indications were progressively implemented: from cytologically undetermined thyroid nodules to intermediate-risk differentiated thyroid cancers. The aim of this study was to review the entire series of patients who underwent a MIVAT, critically analyzing its indications and contraindications and trying to figure out how the indications might be extended. METHODS: From 1998 to 2009, a total of 1,946 patients (1,659 females, 287 males; mean age = 40.2 years) underwent MIVAT in our department. Inclusion criteria were benign thyroid nodules <35 mm, malignant nodules <20 mm, and an ultrasonographically estimated thyroid volume (ETV) <25 cc. The presence of suspicious or metastatic lymph nodes and the presence of severe thyroiditis were considered a contraindication for MIVAT. RESULTS: A total thyroidectomy was performed in 1,435 patients (72.3%). A total lobectomy was performed in 511 cases (26.3%), and a central neck node sampling was associated with total thyroidectomy in 104 cases. Final histology revealed benign disease in 979 cases (51.5%) and a malignancy was diagnosed in 915 cases (48.5%). Unexpected thyroiditis was found on final histology in 17.9% of the patients with benign disease and 30.9% of patients with malignancy. The incidence of thyroiditis was significantly different in these two populations (p < 0.0001). CONCLUSION: Our data confirm the validity of the traditional indications for MIVAT: low-risk differentiated thyroid cancer (DTC), cytologically undetermined nodules, and small-volume benign thyroid disease. The indications may be further and safely extended to those patients with associated thyroiditis and those with intermediate-risk DTC. MIVAT can be proposed on a much larger scale than it was at its onset and cannot be considered an option for only a limited number of patients.


Asunto(s)
Neoplasias de la Tiroides/cirugía , Tiroidectomía/estadística & datos numéricos , Tiroiditis/cirugía , Cirugía Asistida por Video/estadística & datos numéricos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias/métodos , Reoperación/estadística & datos numéricos , Medición de Riesgo , Factores de Riesgo , Neoplasias de la Tiroides/patología , Tiroidectomía/métodos , Adulto Joven
3.
J Nephrol ; 24(5): 604-12, 2011.
Artículo en Inglés | MEDLINE | ID: mdl-21298614

RESUMEN

BACKGROUND: Clinical staff's safety perception is considered an important indicator of the implementation level of safety climate and safety culture. For this purpose, the Safety Climate Survey Questionnaire was submitted to the dialysis clinics staff of the Fresenius Medical Care (FME) network in Italy. Moreover, to explore how standard procedures implementation influences staff opinion of safety levels, the Universal Hygiene Precautions Questionnaire was also submitted. METHODS: Safety Climate Survey and Universal Hygiene Precautions questionnaires were based on 19 and 14 statements, respectively. Staff members (n=346) of 33 dialysis units were involved: 21.4% physicians, 58.1% registered nurses and 20.5% health care assistants (HCAs). RESULTS: Safety Climate mean total score was 81.9%. Medical directors (91.5%) and quality-responsible head nurses (QHRNs) (87.4%) showed higher scores in comparison with staff physicians (82.4%), nurses responsible for hygiene (81.1%) and HCAs (78.8%). Staff nurses (78.9%) showed a significant difference (p<0.05) compared with medical directors. Universal Hygiene Precautions mean total score was 90.8%, not significantly different among medical directors (92%), staff physicians (91.4%), QHRNs (93.2%), nurses responsible for hygiene (91.7%) and staff nurses (91.4%). Only HCAs reported a significantly (p<0.05) lower score (83.6%) compared with medical directors. As the respondents were asked to complete both questionnaires anonymously, a direct correlation between the 2 questionnaires was not possible. CONCLUSION: A relatively high value for Safety Climate was evaluated within the FME network of Italian dialysis clinics. Management showed higher Safety Climate scores than frontline staff. Fostering communication and implementation of training programs are considered valid tools to improve safety.


Asunto(s)
Instituciones de Atención Ambulatoria , Actitud del Personal de Salud , Conocimientos, Actitudes y Práctica en Salud , Evaluación de Procesos y Resultados en Atención de Salud , Grupo de Atención al Paciente/organización & administración , Seguridad del Paciente , Calidad de la Atención de Salud/organización & administración , Diálisis Renal , Técnicos Medios en Salud/organización & administración , Análisis de Varianza , Humanos , Higiene , Italia , Liderazgo , Personal de Enfermería/organización & administración , Cultura Organizacional , Médicos/organización & administración , Evaluación de Programas y Proyectos de Salud , Diálisis Renal/efectos adversos , Encuestas y Cuestionarios , Resultado del Tratamiento , Recursos Humanos
4.
G Ital Nefrol ; 27 Suppl 52: S60-5, 2010.
Artículo en Italiano | MEDLINE | ID: mdl-21132664

RESUMEN

The collection of information about events in the healthcare sector has been documented internationally for more than 25 years. Incident reporting is used for the structured acquisition of information about adverse events to improve patient and healthcare staff safety, prepare corrective action, and prevent event recurrence in the future. The establishment of an incident reporting system requires that the staff involved should be capable of recognizing events which require reporting. The aim of this work was to encourage operators to use the incident reporting system and gradually achieve 100% compliance in the reporting of adverse events and corrective and preventive actions taken. The project was carried out by the staff of one NephroCare dialysis center. The parameters observed were how many times the Variance Report was used, how problems were analyzed, and how many times and by what means the medical and nursing staff took action to correct problems. Ten months from the start of the project 100% reporting was achieved. All selected adverse advents were correctly reported and corrective or preventive action was taken to improve patient care and dialysis center organization. Only effective feedback on the results achieved in terms of safety and tangible improvements by staff will allow the number of reports to be kept high, and maintain participants' compliance with the incident reporting system over the long term.


Asunto(s)
Diálisis Renal/normas , Gestión de Riesgos/métodos , Administración de la Seguridad , Humanos
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