RESUMEN
ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
Asunto(s)
Humanos , Triterpenos/farmacología , Lamiaceae/química , Triterpenos Pentacíclicos/farmacología , Fabaceae/química , Antineoplásicos/farmacología , Triterpenos/aislamiento & purificación , Triterpenos/química , Ensayos de Selección de Medicamentos Antitumorales , Lamiaceae/clasificación , Concentración 50 Inhibidora , Línea Celular Tumoral , Ésteres , Triterpenos Pentacíclicos/aislamiento & purificación , Triterpenos Pentacíclicos/química , Fabaceae/clasificación , Antineoplásicos/aislamiento & purificación , Antineoplásicos/químicaRESUMEN
Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.