1.
Chem Commun (Camb)
; 56(20): 3039-3042, 2020 Mar 10.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32048637
RESUMEN
We report synthesis and enzymatic assays on human histone lysine methyltransferase catalysed methylation of histones that possess lysine and its geometrically constrained analogues containing rigid (E)-alkene (KE), (Z)-alkene (KZ) and alkyne (Kyne) moieties. Methyltransferases G9a and GLP do have a capacity to catalyse methylation in the order K â« KE > KZ â¼ Kyne, whereas monomethyltransferase SETD8 catalyses only methylation of K and KE.