Asunto(s)
Isoquinolinas/farmacología , Tetrahidroisoquinolinas , Animales , Catatonia/inducido químicamente , Cobayas , Antagonistas de los Receptores Histamínicos , Histidina Descarboxilasa/antagonistas & inhibidores , Humanos , Isoquinolinas/metabolismo , Isoquinolinas/toxicidad , Masculino , Ratones , Anafilaxis Cutánea Pasiva/efectos de los fármacos , Reserpina/antagonistas & inhibidores , Serotonina/farmacología , Distribución TisularRESUMEN
A new and rapid method of quantitative salivary gland scintigraphy has been developed. The uptake of pertechnetate in the glandular tissue and in a reference area in the neck are measured. The ratio between these measurements gives an index of salivary gland activity. By using this activity index, quantitative information on the functional state of the parotid and submandibular glands can be obtained. In cases of xerostomia such measurements may be particularly helpful in differentiating Sjögren's syndrome and sialosis and hence in the choice of appropriate treatment.
Asunto(s)
Neoplasias de las Glándulas Salivales/diagnóstico , Tecnecio , Xerostomía/diagnóstico , Adulto , Anciano , Diagnóstico Diferencial , Femenino , Humanos , Persona de Mediana Edad , Glándula Parótida/patología , Saliva/metabolismo , Enfermedades de las Glándulas Salivales/patología , Conteo por Cintilación , Síndrome de Sjögren/diagnósticoRESUMEN
The scintigraphy of salivary glands with technetium-99m pertechnetate is predisposed to be an excellent test for evaluating salivary gland function. But the absence of a sufficiently precise and simple quantitative analysis procedure of the technetium uptake has reduced its clinical use. For this reason, the authors propose a new and quick method: the quantitative salivary gland scintigraphy. With an uptake index (ratio of technetium uptake between the glandular tissue and a cervical reference) they get precise quantitative information on functional activity. Among other applications, the test allows to make within a few minutes, in a case of xerostomia, the differential diagnosis between Sjäogren syndrome and sialosis.
