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1.
R Soc Open Sci ; 11(5): 240352, 2024 May.
Artículo en Inglés | MEDLINE | ID: mdl-38721133

RESUMEN

To maximize the use of solar energy and increase the building area of solar greenhouses in China, a light radiation model for solar greenhouses is established. This model integrates previous research results with the solar motion principle, meteorological data and the optical properties of materials. The results indicate that optimizing the structural curve of the south roof of the greenhouse improves both internal land utilization and solar capture. After optimization, the internal land utilization rate of the solar greenhouse increased by 42 m2, with a respective 15.2 and 0.78% increase in lighting on the southern roof and ground. The light interception by the back wall of the greenhouse was reduced by 0.67%, while the total light interception increased by 2.22%. The research results identify the optimal shoulder height (0.7 m) and overall height (2 m) for the second-generation solar greenhouse in Liaoshen. The optimal curve functions Y 1 and Y 2 for the south roofs of greenhouses are calculated according to the actual construction requirements. This article verifies the structural safety of the solar greenhouse after renovation and shows that optimizing the shoulder height increases the structural stability and safety of the greenhouse.

2.
J Pharm Pharmacol ; 74(11): 1618-1628, 2022 Nov 04.
Artículo en Inglés | MEDLINE | ID: mdl-36170125

RESUMEN

OBJECTIVES: Paeonol (PAE) is an active ingredient with anti-inflammatory and antioxidant properties. This study was designed to investigate the effect of PAE on acute pancreatitis (AP). METHODS: AP was induced by the intraperitoneal injection of 20% l-arginine (4 g/kg) for 6 h. Mice were pretreated with PAE (25, 50 or 100 mg/kg) intragastrically for 5 days. The histological damage and alterations of biochemical indicators, inflammatory cytokines and oxidative stress factors in AP mice were detected. The Nrf2 and NF-κB pathways were examined to illustrate the potential mechanism. KEY FINDINGS: In AP model, we found that PAE attenuated histological injury of pancreatic tissues, reduced the serum levels of α-amylase and increased Ca2+ contents in a dose-dependent manner. The white blood cell content, and IL-1ß, IL-6 and TNF-α levels in the serum of AP mice were reduced by PAE. Furthermore, PAE caused a reduction of MPO and MDA levels, accompanied by an increase in SOD activity in the pancreas of AP mice. We also demonstrated that the alterations of Nrf2 and NF-κB pathways in AP mice were reversed by PAE. CONCLUSIONS: PAE attenuates inflammation and oxidative stress in the development of AP by the regulation of Nrf2 and NF-κB pathways.


Asunto(s)
FN-kappa B , Pancreatitis , Ratones , Animales , FN-kappa B/metabolismo , Factor 2 Relacionado con NF-E2/metabolismo , Pancreatitis/inducido químicamente , Pancreatitis/tratamiento farmacológico , Pancreatitis/prevención & control , Enfermedad Aguda
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