RESUMEN
The sponge Dysidea herbacea was collected from the Mandapam Coast, Tamilnadu, India. Isolated gram quantities of hydroxylated polybrominated diphenyl ether (HO-PBDE) and semi-synthesized a series of new PBDEs derivatives and tested them for antibacterial and cytotoxic activities.
Asunto(s)
Dysidea/química , Éteres Difenilos Halogenados/síntesis química , Animales , Línea Celular Tumoral , Supervivencia Celular/efectos de los fármacos , Éteres Difenilos Halogenados/farmacología , Humanos , Estructura MolecularRESUMEN
Screening of Aspergillus funiculosus for bioactive secondary metabolites produced kojic acid, which is know to have wide range of biological properties. It is very active against Gram-negative bacteria, such as Pseudomonas aeruginosa and Escherichia coli, but moderately active against yeasts and Gram-positive bacteria except Staphylococcus epidermidis. Filamentous Fungi are more sensitive to kojic acid. When it exposed to larvicidal activity on Aedes aegypti third instar larvae are more sensitive than early fourth instar larvae.
RESUMEN
An unusual novel and significant anti-oxidant 1,2-dibenzoyl glycoside, natansnin (1), has been isolated from Salvinia natans. The structure of 1 was established by the study of NMR and CD spectral data.
Asunto(s)
Antioxidantes/química , Helechos/química , Glicósidos/química , Espectroscopía de Resonancia Magnética , Estructura MolecularRESUMEN
A total synthesis of yashabushidiol (1a), a linear diarylheptanoid having 1,3- diol system and its analogues has been achieved by alkynylation of 3-hydroxy-5-phenyl pentanal with substituted phenyl acetylenes. All the compounds have shown significant anti-proliferative activity on human leukemia (THP-1, U-937) and melanoma (A-375) cell lines. Compounds 2a and 2b were found to be most potent with an IC(50) of 12.82 microg/mL and 12.62 microg/mL, respectively, on THP-1 leukemia cell line.
Asunto(s)
Antineoplásicos/síntesis química , Heptanos/síntesis química , Fenoles/síntesis química , Antineoplásicos/química , Antineoplásicos/toxicidad , Línea Celular Tumoral , Ensayos de Selección de Medicamentos Antitumorales , Heptanos/toxicidad , Humanos , Fenoles/toxicidadRESUMEN
Two new bastadin alkaloids, bastadins-22 (1) and 23 (2), together with six known bastadins, bastadins-6 (3), -12 (4) (formerly basatadin-9), -14 (5), -15 (6), -16 (7), -19 (8), and a common steroid cholesterol were isolated from the sponge Dendrilla cactos. The structures of the isolates were established by the study of extensive spectroscopic analysis (1D and 2D NMR and MS data). Anticancer activity of the isolates has been carried out against Sup-T(1) cancer cells (T cell lymphoma).
