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2.
Epilepsia ; 63(9): 2172, 2022 09.
Artículo en Inglés | MEDLINE | ID: mdl-35979603
6.
Nutrients ; 14(2)2022 Jan 17.
Artículo en Inglés | MEDLINE | ID: mdl-35057580

RESUMEN

The objective of the present research was to review the state of the art on the consequences of drinking coffee at the different levels of the gastrointestinal tract. At some steps of the digestive process, the effects of coffee consumption seem rather clear. This is the case for the stimulation of gastric acid secretion, the stimulation of biliary and pancreatic secretion, the reduction of gallstone risk, the stimulation of colic motility, and changes in the composition of gut microbiota. Other aspects are still controversial, such as the possibility for coffee to affect gastro-esophageal reflux, peptic ulcers, and intestinal inflammatory diseases. This review also includes a brief summary on the lack of association between coffee consumption and cancer of the different digestive organs, and points to the powerful protective effect of coffee against the risk of hepatocellular carcinoma. This review reports the available evidence on different topics and identifies the areas that would most benefit from additional studies.


Asunto(s)
Café , Tracto Gastrointestinal , Bilis/fisiología , Cafeína/administración & dosificación , Café/efectos adversos , Femenino , Cálculos Biliares/prevención & control , Ácido Gástrico/fisiología , Reflujo Gastroesofágico , Microbioma Gastrointestinal , Motilidad Gastrointestinal , Neoplasias Gastrointestinales , Tracto Gastrointestinal/efectos de los fármacos , Humanos , Enfermedades Inflamatorias del Intestino , Masculino , Páncreas/fisiología , Úlcera Péptica , Saliva/enzimología
10.
Eur J Nutr ; 60(3): 1197-1235, 2021 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-33442757

RESUMEN

PURPOSE: Most of the existing literature reports no association or a slight negative association between coffee consumption and the risk of developing breast cancer. However, the level of risk differs when considering various subgroups, such as menopausal status, hormonal status of the tumor or genetic mutations. The present review based on a literature search sets the point on the potential influence of a common daily drink, coffee, on the risk of developing breast cancer in the general population, in different subgroups of women and the consequences of drinking coffee after breast cancer has been diagnosed and treated. RESULTS: This review confirms that in the general population, there is no association between coffee intake and breast cancer risk or a slight protective effect, even at high dosages. Coffee is inversely associated with breast cancer risk in postmenopausal women and in women carrying a BRCA1 mutation. Possible risk differences exist between slow and fast caffeine metabolizers and with weight. Coffee consumption after breast cancer diagnosis and surgery, associated with tamoxifen and/or radiotherapy, reduced the occurrence of early events. The effects of coffee intake are less clear in other subgroups, mainly premenopausal women, women carrying a BRCA2 mutation and tumors with variable hormonal status (positive or negative for ER/PR) and would need additional studies.


Asunto(s)
Neoplasias de la Mama , Café , Neoplasias de la Mama/epidemiología , Neoplasias de la Mama/genética , Cafeína , Femenino , Humanos , Premenopausia , Factores de Riesgo , Tamoxifeno
12.
Addict Biol ; 26(2): e12938, 2021 03.
Artículo en Inglés | MEDLINE | ID: mdl-32666571

RESUMEN

Our previous studies consistently showed that MDMA-induced locomotor hyperactivity is dramatically increased by coadministration of ethanol (EtOH) in rats, indicating possible potentiation of MDMA abuse liability. Thus, we aimed to identify the brain region(s) and neuropharmacological substrates involved in the pharmacodynamics of this potentiation. We first showed that potentiation of locomotor activity by the combination of ip administration of EtOH (1.5 g/kg) and MDMA (6.6 mg/kg) is delay sensitive and maximal when both drugs are injected simultaneously. Then, we used the 2-deoxyglucose quantitative autoradiography technique to assess the impact of EtOH, MDMA, or their combination on local cerebral metabolic rates for glucose (CMRglcs). We showed a specific metabolic activation in the ventral striatum (VS) under MDMA + EtOH versus MDMA or EtOH alone. We next tested if reversible (tetrodotoxin, TTX) or permanent (6-hydrodoxyopamine, 6-OHDA) lesion of the VS could affect locomotor response to MDMA and MDMA + EtOH. Finally, we blocked dopamine D1 or glutamate NMDA receptors in the VS and measured the effects of MDMA and MDMA + EtOH on locomotor activity. We showed that bilateral reversible inactivation (TTX) or permanent lesion (6-OHDA) of the VS prevented the potentiation by EtOH of MDMA-induced locomotor hyperactivity. Likewise, blockade of D1 or NMDA receptors in the VS also reduced the potentiation of MDMA locomotor activity by EtOH. These data indicate that dopamine D1 and glutamate NMDA receptor-driven mechanisms in the VS play a key role in the pharmacodynamics of EtOH-induced potentiation of the locomotor effects of MDMA.


Asunto(s)
Etanol/farmacología , N-Metil-3,4-metilenodioxianfetamina/farmacología , Estriado Ventral/efectos de los fármacos , Animales , Combinación de Medicamentos , Sinergismo Farmacológico , Etanol/administración & dosificación , Locomoción/efectos de los fármacos , Masculino , N-Metil-3,4-metilenodioxianfetamina/administración & dosificación , Oxidopamina/farmacología , Ratas , Ratas Long-Evans , Receptores de Dopamina D1/antagonistas & inhibidores , Receptores de N-Metil-D-Aspartato/antagonistas & inhibidores , Tetrodotoxina/farmacología
13.
Nutrients ; 12(10)2020 Oct 14.
Artículo en Inglés | MEDLINE | ID: mdl-33066651

RESUMEN

The health implications of acrylamide in food are a matter of concern based on toxicological studies in rodents, which showed that doses of acrylamide more than 100 times higher than those estimated to result from dietary exposure in humans are carcinogenic; however, the cancer types reported in rodents are species-specific, and whether these results can be extrapolated to humans is still in question. In fact, human epidemiological studies revealed a general lack of association between dietary acrylamide exposure and the incidence of different cancer types. Even occupational exposure to acrylamide, resulting in acrylamide exposure nearly 10 times higher than dietary exposure, did not increase tumor occurrence. Furthermore, the consumption of coffee, which is a main contributor of dietary acrylamide exposure, actually decreases the overall incidence of cancer in humans and afford global health benefits, increasing both lifespan and healthspan on ageing. This paradox clearly illustrates the risk of evaluating an individual molecule independently of its complete food matrix, which may have other components that completely override the effects of the considered molecule.


Asunto(s)
Acrilamida/efectos adversos , Acrilamida/análisis , Café , Contaminación de Alimentos/análisis , Neoplasias/prevención & control , Medición de Riesgo , Acrilamida/toxicidad , Envejecimiento , Animales , Café/química , Análisis de los Alimentos , Manipulación de Alimentos , Humanos , Longevidad , Ratones , Neoplasias/inducido químicamente , Ratas , Riesgo
16.
J Agric Food Chem ; 68(17): 4731, 2020 Apr 29.
Artículo en Inglés | MEDLINE | ID: mdl-32233485
20.
Epilepsia Open ; 3(Suppl Suppl 1): 69-89, 2018 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-30411072

RESUMEN

The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force created the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve standardization of experimental designs. This article concerns the parameters that can be measured to assess the physiologic condition of the animals that are used to study rodent models of epilepsy. Here we discuss CDEs for physiologic parameters measured in adult rats and mice such as general health status, temperature, cardiac and respiratory function, and blood constituents. We provide detailed CDE tables and case report forms (CRFs), and with this companion manuscript we discuss the monitoring of different aspects of physiology of the animals. The CDEs, CRFs, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of biomarkers and new treatments for epilepsy.

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