Bilateral ulna fractures associated with bisphosphonate therapy.

We report a case of bilateral ulna stress fractures following bilateral femoral fractures associated with long-term bisphosphonate use. The patient is an 84-year-old woman receiving 15 years of bisphosphonate therapy. She did not have any preexisting medical conditions which are known secondary causes of bone loss. She was mostly housebound and used a walking frame for ambulation. She presented with atraumatic right ulna pain and subsequent atraumatic left ulna pain a month later. She was treated conservatively in backslabs and her bisphosphonate was stopped. Investigations did not reveal any secondary causes of osteoporosis or metabolic bone disorders.

A case of an atypical femoral fracture associated with bacterial biofilm--pathogen or bystander?

We report a case of an 86-year-old woman with an atypical femoral fracture (AFF) who was treated with intramedullary nailing followed by lateral femoral plating. She developed a second femoral shaft fracture distal to the intramedullary nail which required a second operation. Biopsy of the periosteum overlying the site of the initial proximal AFF was sent for pathogen analysis. Using the Ibis T5000 platform and the BAC plate assay, a polymicrobial infection was diagnosed consisting of Bifidobacterium subtile and Pseudomonas mendocina. This raises the possibility that bacterial infections may play some role in atypical fractures of the femur.

Distribution of atypical fractures and cortical stress lesions in the femur: implications on pathophysiology.

INTRODUCTION: Some authors have hypothesised that atypical femur fractures occur due to tensile mechanism of failure. We studied the distribution of such lesions along the femur shaft to determine if they concentrate in regions that are subject to tensile loading. METHODS: From May 2004 to March 2010, radiological reviews of 48 patients aged 69 +/- 10.4 (range 47-92) years with atypical femoral fractures and lesions were performed. The absolute distance of each lesion from the greater trochanter and the ratio of the distance of each lesion from the greater trochanter expressed as a percentage of the entire femur length were measured. RESULTS: All periosteal reactions and cortical stress lesions occurred in the lateral cortex. There were 35 right femoral lesions (28 complete fractures and seven cortical stress reactions), with a median distance of 108.3 +/- 54.0 (range 67.0-270.4) mm from the greater trochanter and a median ratio of 23.9 +/- 11.7 (range 15.7-58.6) percent of the entire femoral length. There were 38 left femoral lesions (27 complete fractures and 11 cortical stress reactions), with a median distance of 109.9 +/- 43.1 (range 73.6-246.2) mm from the greater trochanter and a median ratio of 24.4 +/- 9.1(range 16.3-51.1) percent of the entire femoral length. CONCLUSION: Based on previously established femoral shaft loading characteristics, atypical lesions were clustered at the region of maximal tensile loading. No lesion occurred in regions that were subject to compressive loading. This unique distribution supports a tensile mechanism of failure in such lesions.

Metal phthalocyanine nanoribbons and nanowires.

Nanoribbons and nanowires of different metal phthalocyanines (copper, nickel, iron, cobalt, and zinc), as well as copper hexadecafluorophthalocyanine (F(16)CuPc), have been grown by organic vapor-phase deposition. Their properties, as a function of substrate type, source-to-substrate distance, and substrate temperature, were studied by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and absorption measurements. The size and morphology of the nanostructures were found to be mainly determined by the substrate temperature. The crystal structure was dependent on the substrate temperature as well. At substrate temperatures below 200 degrees C, in addition to straight nanoribbons, twisted nanoribbons were found for all investigated materials except F(16)CuPc, which formed helical nanoribbons upon exposure to an electron beam. The formation of different nanostructures (nanoribbons, twisted nanoribbons, and helical nanoribbons) is discussed.