RESUMEN
In this study, the anti-osteogenic properties of the volatile oil extracted from Homalomena gigantea rhizome using ethyl acetate (EtOAc) and methanol (MeOH) were examined. Gas chromatography-mass spectrometry (GC-MS) was employed for the identification of volatile components. Following this, bioassays were performed to evaluate their effects on osteogenesis, encompassing parameters like cell viability, osteoblast differentiation, collagen synthesis and mineralization. The GC-MS analysis revealed 19 compounds in the EtOAc extract and 36 compounds in the MeOH extract. In the MeOH extract, major constituents included bis(2-ethylhexyl) terephthalate (13.83%), linalool (9.58%), palmitic acid (6.55%) and stearic acid (4.29%). The EtOAc extract contained bis(2-ethylhexyl) terephthalate (16.64%), palmitic acid (5.60%) and stearic acid (3.11%) as the predominant components. Both the EtOAc and MeOH extracts of H. gigantea exhibited promising potential for further investigation in anti-osteoporosis research. These findings contribute to the exploration of natural compounds with potential anti-osteoporotic properties, expanding our understanding of their therapeutic potential.
Asunto(s)
Cromatografía de Gases y Espectrometría de Masas , Aceites Volátiles , Osteogénesis , Extractos Vegetales , Rizoma , Osteogénesis/efectos de los fármacos , Rizoma/química , Extractos Vegetales/farmacología , Extractos Vegetales/química , Extractos Vegetales/aislamiento & purificación , Aceites Volátiles/farmacología , Aceites Volátiles/química , Aceites Volátiles/aislamiento & purificación , Animales , Supervivencia Celular/efectos de los fármacos , Osteoblastos/efectos de los fármacos , Diferenciación Celular/efectos de los fármacos , Ratones , Ácido Palmítico/farmacología , Monoterpenos Acíclicos/farmacologíaRESUMEN
Zeolitic aluminophosphate, a three-dimensional microporous material, with an average pore size of 0.38â nm is good candidate for molecular sieve application in CO2 gas separation. The separation of CO2 /CH4 gas mixtures for precombustion processes is desirable from the standpoint of both environmental concerns and energy efficiency. This study concerns an environmentally friendly method to synthesize zeolitic aluminophosphate thin films on various configurations and low-cost kaolin porous substrates with high performance in the separation of CO2 /CH4 mixtures. The membranes are prepared by a gelless seed growth method that uses lower amounts of chemicals, forms no liquid gel, chemical waste, or byproducts and generates no washing water. The obtained membranes show very high selectivity for CO2 with a CO2 /CH4 separation factor above 1000 in the separation of CO2 /CH4 gas mixtures.