Selective dry cow therapy effect on milk yield and somatic cell count: A retrospective cohort study.

Antibiotic dry cow therapy (aDCT) at the end of lactation is an effective mastitis control measure. Selective dry cow therapy means that only infected or presumed-infected cows are treated, instead of aDCT being used as a treatment for all cows. Because antibiotic resistance poses a global threat, livestock production is under increasing pressure to reduce antibiotic use. Changes in management should not, however, impair animal welfare or cause significant economic losses. Our objective was to compare milk yield and somatic cell count (SCC) between aDCT-treated and untreated cows in herds that used selective aDCT, taking into account risk factors for reduced yield and high SCC. The information source was 2015 to 2017 Dairy Herd Improvement data, with 4,720 multiparous cows from 172 Finnish dairy farms. The response variables were test-day milk yield (kg/d) and naturally log-transformed composite SCC (×1,000 cells/mL) during the first 154 d in milk (DIM). The statistical tool was a linear mixed-effects model with 2-level random intercepts, cows nested within herds, and a first-order autoregressive [AR(1)] correlation structure. The overall proportion of aDCT-treated cows was 25% (1,176/4,720). Due to the interaction effect, SCC on the last test day prior to dry-off affected postcalving milk yield differently in aDCT-treated cows than in untreated cows. A higher SCC prior to dry-off correlated with a greater daily yield difference after calving between cows treated and untreated. The majority of cows had SCC < 200,000 cells/mL before dry-off, and as SCC before dry-off decreased, difference in yield between aDCT-treated and untreated cows decreased. Postcalving SCC was lower for aDCT-treated cows compared with untreated cows. To illustrate, for cows with an SCC of 200,000 cells/mL before dry-off, compared with untreated cows, aDCT-treated cows produced 0.97 kg/d more milk and, at 45 DIM, had an SCC that was 20,000 cells/mL lower. Higher late-lactation SCC and lactational mastitis treatments were associated with higher postcalving SCC. A dry period lasting more than 30 d was associated with higher yields but not with SCC. Our findings indicate that a missed aDCT treatment for a high-SCC cow has a negative effect on subsequent lactation milk yield and SCC, which emphasizes the importance of accurate selection of cows to be treated.

Dry cow therapy and early lactation udder health problems-Associations and risk factors.

Mastitis remains the most expensive disease of dairy cows, and antibiotic dry cow therapy (DCT) at dry-off is an important part of mastitis control. Regardless of the infection status, blanket DCT is administered to all quarters of all cows, which is controversial due to the worldwide problem of antimicrobial resistance. Even though selective DCT of only infected cows is a more sustainable approach, choosing animals for treatment is not always straightforward. Our aim was to evaluate whether the herd-level DCT approach is associated with early lactation udder health problems, taking into account the cow characteristics. The information source was 2015-2017 Dairy Herd Improvement data with 7461 multiparous cows from 241 Finnish dairy herds. Information on the herd-level DCT approach was obtained from farmers' questionnaire responses in 2017, and the three different approaches were selective DCT, blanket DCT, and no DCT. The statistical tool for the data analysis was a generalized linear mixed model with a random herd effect for binary outcomes and a linear mixed model with a random herd effect for a continuous outcome. The two binary outcomes were the odds of having high milk somatic cell count (SCC ≥ 200 000 cells/mL) on the first test-day within 5-45 days in milk (DIM) and the odds of mastitis treatment in early lactation up to 45 DIM. The third outcome was the mean milk lnSCC (× 1000 cells/mL) within 120 DIM. Selective DCT was the prevailing treatment practice in our data. Blanket DCT was associated with lower SCC after calving. Cows more likely to have high SCC after calving were older cows, cows with high average SCC during the previous lactation, and cows with high milk yield near dry-off. A mastitis treatment in the early lactation was more likely if, during the previous lactation, the cow had high average SCC, high peak milk production, or high milk yield near dry-off. Our findings indicate that DCT is still effective in mastitis control. Cows with high milk yield, especially near dry-off, and cows with persistently high SCC require attention when considering next lactation udder health.

Antibiotic dry cow therapy, somatic cell count, and milk production: Retrospective analysis of the associations in dairy herd recording data using multilevel growth models.

Antibiotic dry cow therapy (DCT) is an important part of most mastitis control programs. Updating DCT recommendations is an ongoing topic due to the global problem of antimicrobial resistance. Finland, along with other Nordic countries, has implemented selective DCT for decades. Our study analyzed Dairy Herd Improvement (DHI) information from 241 Finnish farmers who participated in a survey about their drying-off practices. The aim was to evaluate herd-level associations between milk somatic cell count (SCC), milk production, and various antimicrobial DCT approaches both cross-sectionally in 2016 and longitudinally in 2012-2016. The three DCT approaches in the study were selective, blanket, and no DCT use. An additional aim was to evaluate whether dynamic changes occurred in herd-average SCC and annual milk production over five years, and whether these potential changes differed between different DCT approaches. The method for the longitudinal analyses was growth modeling with random coefficient models. Differences in SCC and milk production between farms with different DCT approaches were minor. Regardless of the farm's DCT approach, annual milk production increased over the years, while average SCC was reasonably constant. The variability in SCC and milk production across all DCT groups was low between years, and most of the variability was between farms. Compared to other milking systems, farms with automatic milking system (AMS) had higher SCC, and in 2016 higher milk production. The results of this study suggest that it is possible to maintain low herd-average SCC and good milk production when using selective DCT and following the guidelines for prudent antimicrobial use. Average SCC and milk production varied across the herds, suggesting that advice on DCT practices should be herd-specific. The methodology of growth modeling using random coefficient models was applicable in analyzing longitudinal data, in which the time frame was relatively short and the number of herds was limited.