Advanced Strategies for Strengthening the Immune Activation Effect of Traditional Antitumor Therapies.

The utilization of traditional therapies (TTS), such as chemotherapy, reactive oxygen species-based therapy, and thermotherapy, to induce immunogenic cell death (ICD) in tumor cells has emerged as a promising strategy for the activation of the antitumor immune response. However, the limited effectiveness of most TTS in inducing the ICD effect of tumors hinders their applications in combination with immunotherapy. To address this challenge, various intelligent strategies have been proposed to strengthen the immune activation effect of these TTS, and then achieve synergistic antitumor efficacy with immunotherapy. These strategies primarily focus on augmenting the tumor ICD effect or facilitating the antigen (released by the ICD tumor cells) presentation process during TTS, and they are systematically summarized in this review. Finally, the existing bottlenecks and prospects of TTS in the application of tumor immune regulation are also discussed.

Government subsidies and innovation in new energy vehicle companies: An empirical study of new energy vehicle listed companies based on Shanghai and Shenzhen A-shares.

The panel data of 50 new energy vehicle enterprises in Shanghai and Shenzhen A-shares from 2012 to 2021 are selected to empirically analyze the impact of government subsidies on the innovation of new energy vehicle enterprises and to further discuss the differences between such an impact in different forms and regions. The study finds that, first, government subsidies have a certain promotion effect on the innovation of new energy vehicle enterprises, and an inverted U-shaped relationship exists thereof. Second, at the enterprise level, government subsidies have a significant effect on the innovation of non-state enterprises, downstream vehicle enterprises, and enterprises with lower establishment years, and the inverted-U trend is evident. Third, at the regional level, government subsidies have a more significant effect on the innovation of enterprises in non-eastern regions and low-environmental regulation regions, and the inverted-U-shaped relationship trend is more apparent. The study establishes the nonlinear relationship between government subsidies and the innovation of new energy vehicle enterprises through empirical research, which expands the theory of enterprise innovation and has a certain guiding significance for improving the innovation capability of new energy vehicle enterprises in the future.