1.
Endoscopy
; 53(11): E413-E414, 2021 11.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33445202
2.
Nat Prod Res
; 30(8): 904-11, 2016.
Artículo
en Inglés
| MEDLINE
| ID: mdl-26305695
RESUMEN
Two new ursane-type triterpenoids (1, 2) attached to isopropylidenedioxy group were isolated from the seeds of blackberry (Rubus fructicosus L., Rosaceae) along with two known ursane-type triterpenoids, 2,3-O-isopropylidenyl-2α,3α,19α-trihydroxyurs-12-en-28-oic acid (3) and 1ß-hydroxyeuscaphic acid (4). The chemical structures of 1 and 2 were determined to be 2,3-O-isopropylidene-1ß,2ß,3ß,19α-tetrahydroxyurs-12-en-28-oic acid and 1,2-O-isopropylidene-1ß,2α,3α,19α-tetrahydroxyurs-12-en-28-oic acid, respectively, based on spectroscopic data. Additionally, their cytotoxic activity towards HL-60 human leukaemia cells was evaluated. Among them, 3 demonstrated a clear cytotoxic activity with 72.8 µM of IC50 value.