An exploratory analysis of the relationship between paternal age at pregnancy and difficulties symptomatic of specific learning disorders among Japanese undergraduate students.

Objective: Causes and risk factors of neurodevelopmental disorders originate in the prenatal and perinatal periods. Several studies have demonstrated a relationship between prenatal and perinatal medical records, including maternal and paternal age at pregnancy, and the neurodevelopmental disorders, especially attention deficit/hyperactivity disorder and autism spectrum disorder. However, previous studies showed an association between specific learning disorders and environmental toxins such as lead and tobacco smoke, but not parental age. Patients and Methods: This study included 993 university freshmen, and their prenatal and perinatal medical data was collected from maternal and child handbooks. A mental health assessment questionnaire consisting of 24 items covering symptoms associated with neurodevelopmental disorders was administered, corresponding to aspects of attention deficit/hyperactivity disorder, autism spectrum disorder, and learning disorders. The relationship between prenatal and perinatal medical data and questionnaire results was statistically analyzed. Results: The number of available records was 881 (88.7%). Using Spearman's rank correlation coefficient analysis and trend analysis, a weak but statistically significant relationship was confirmed between paternal age at pregnancy and the score for learning disorder difficulties. Conclusion: Error accumulation in meiosis during spermatogenesis may be one of the risk factors of learning disorders.

Relationship between type A behavior patterns and risk of temporomandibular disorder in Japanese undergraduate students.

Objective: Several studies have demonstrated the relationship between temporomandibular disorder (TMD) and emotional stress. Nonetheless, few surveys have examined the relationship between type A behavior patterns and TMD. The aim of this study was to clarify the relationships among TMD, type A behavior patterns, bruxism, and emotional stress in Japanese undergraduate students. Methods: This study was undertaken in Nayoro City, Japan, in 2015, among students of Nayoro City University. The survey was conducted through an anonymous, self-administered, multiple-choice questionnaire. Information was gathered on items evaluating the extent of TMD symptoms, bruxism, type A behavior patterns, and proneness and sensitivity to emotional stress. Results: The questionnaire recovery rate was 31.8% (175/551). There was a high likelihood of TMD in 16.1% of respondents, which is comparable to the findings of previous surveys on Japanese high school students. In keeping with previous studies, we confirmed significant relationships between TMD and both emotional stress and bruxism. A weak but statistically significant association was found between TMD and type A behavior patterns. Conclusion: We propose that TMD may be one of the diseases related to the type A behavior pattern.

An exploratory analysis of the impact of a university campus smoking ban on staff and student smoking habits in Japan.

BACKGROUND: Smoking bans in public places have been shown to have an impact on smoking habits, however the potential influence of a university smoking ban on faculty and staff smoking habits remains elusive. METHODS: This cross sectional study was implemented in Nayoro City, Japan in 2011, among the faculty and students of the Nayoro City University. Five years after the declaration of a total ban on smoking on a university campus, the smoking characteristics of all students, teachers and office workers, and the policy's impact on smokers were investigated. The survey was conducted through an anonymous, self-administered, multiple-choice questionnaire. Information was gathered on the characteristics and smoking characteristics of respondents, and the smokers attitudes toward smoking. RESULTS: The recovery rate was 62.1%. Among respondents, smoking prevalence was 17.9% in teachers and office workers, and 4.0% in students. Among all smokers, 46.4% did not abstain from smoking while at the university and they indicated their smoking areas were "on the streets next to the campus": 16 and "outdoors on campus": 3, respectively. As for smokers, 29.6% of them reduced the number of cigarettes smoked per day as a result of the smoking ban. None of the ex-smokers replied that their principal motivation for quitting smoking was the smoking ban. CONCLUSIONS: The ban on smoking served a motivator for smokers to reduce in smoking, but not serve as an effective motivator to quit smoking.

Early infantile growth and cardiovascular risks in adolescent Japanese women.

OBJECTIVE: Early life events connected with the risk of later disease can occur not only in utero, but also in infancy. In study of the developmental origins of health and disease, the relationship between infantile growth patterns and adolescent body mass index and blood pressure is one of the most important issues to verify. MATERIALS AND METHODS: We analyzed the correlation of current body mass index and systolic blood pressure of 168 female college students with their growth patterns in utero and in infancy. RESULTS: Body mass index and systolic blood pressure in adolescence showed positive correlations with changes in weight-for-age z scores between 1 and 18 months but not with those between 18 and 36 months. Stepwise multiple regression analysis showed that both change in weight-for-age z scores from 1 to 18 months and body mass index at 1 month were significantly and independently associated with systolic blood pressure in adolescence. Body mass index at 36 months was positively correlated with body mass index in adolescence, while body mass index at birth was negatively correlated with body mass index in adolescence. CONCLUSION: Our findings shows that restricted growth in utero and accelerated weight gain in early infancy are associated with the cardiovascular risk factors of high systolic blood pressure and high body mass index in adolescence. In Japan, an increasing proportion of low birth weight infants and accelerated catch-up growth after birth have been observed in recent decades. This might be an alarming harbinger of an increase in diseases related to the developmental origins of health and disease in Japan.

Post-traumatic stress disorder in pre-school aged children after a gas explosion.

UNLABELLED: To evaluate the sensitivity of diagnostic criteria for post-traumatic stress disorder (PTSD) in pre-school aged children involved in a gas explosion, post-traumatic symptoms of the children were investigated four times after the accident, immediately, 10 days, 6 months, and 1 year later. Using symptoms at 6 months after the accident, sensitivity of diagnostic criteria was assessed by comparing the fourth edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), and the alternative criteria for infants and young children [10]. In addition, the published Child Post-Traumatic Stress Disorder Reaction Index (CPTSD-RI) and its modified version proposed by us were also evaluated their sensitivity to rate the symptoms. Girls had a tendency to show more post-traumatic symptoms than boys. Although no children met DMS-IV criteria for PTSD, 8 children out of 32 were diagnosed as having PTSD with alternative criteria. With our modified CPTSD-RI, all eight children were decidedly more statistically distinguishable from those without PTSD than with original index. CONCLUSION: our data indicate that the sensitivity of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (4th edition) and the Child Post-Traumatic Stress Disorder Reaction Index in rating symptoms of pre-school aged children is not sufficient. The alternative criteria of the former and modified version of the latter would be the better choice in this age group.

Fetal growth and the timing of exposure to maternal smoking.

BACKGROUND: Maternal smoking during the third trimester reduces the birthweight of the full-term neonate. We assessed the relationship between the timing of exposure to maternal smoking, gestational period, weight and body length for both full-term and preterm neonates. METHODS: A retrospective study with a questionnaire was conducted in 1194 infants who participated in the official medical examination for 3-year-old infants. RESULTS: The risk of preterm birth from mothers who smoked during any trimesters was significantly increased. The body length of neonates whose mothers smoked during the third trimester was shorter than that of neonates whose mothers did not smoke during the third trimester. The weight of full-term neonates whose mothers smoked during the third trimester was lighter than that of neonates whose mothers did not smoke during the third trimester. CONCLUSIONS: Maternal smoking during any trimesters increased the risk of preterm birth. Maternal smoking during the third trimester reduced the body length of both full-term and preterm neonates, and the birthweight of the full-term neonate in a somewhat dose-dependent manner.