RESUMEN
It has been well documented that memory difficulties in patients with anterior skull base meningioma may improve after tumour resection. However, there have been few reports on studies where precise testing of cognitive function has been conducted before and after surgery. Here we report 2 cases of anterior skull base meningioma where 2 tests of cognitive function, the Wechsler adult intelligence scale-revised (WAIS-R) and the Wechsler memory scale-revised (WMS-R), were performed by the patient before and after surgical treatment. After the operation there was a dramatic increase in the performance IQ as measured by the WAIS-R. In addition, the scores for both the "Attention/Concentration" and the "Delayed Recall" subsets of the WMS-R scale improved. There were differences between the 2 patients in the length of time required for functional recovery and this was thought to be due to the tumour size and the age of the patient. The use of these scales would enable physicians who are treating patients with anterior skull base meningioma to assess the recovery time that is likely to be needed before full return of cognitive function after surgery.
Asunto(s)
Trastornos del Conocimiento/etiología , Meningioma/psicología , Meningioma/cirugía , Neoplasias de la Base del Cráneo/psicología , Neoplasias de la Base del Cráneo/cirugía , Adulto , Humanos , Masculino , Memoria/fisiología , Persona de Mediana Edad , Recuperación de la Función/fisiología , Factores de Tiempo , Resultado del Tratamiento , Escalas de WechslerRESUMEN
The purpose of the present study was to determine if adenovirus-mediated transfection of a syngeneic mouse brain tumor with the gene encoding B7.1 enhances immunogenicity against tumor. Malignant astrocytoma cells were transfected with adenoviral vectors carrying the B7.1 gene (AdB7). Immunocytochemical analysis confirmed the expression of B7.1 in vitro and in vivo. To investigate the effects of B7.1 expression on tumorigenicity of the malignant astrocytoma, mice were implanted intracerebrally with B7.1-transfected glioma cells. There was no significant difference in proliferation between B7.1-transfected cells and controls in vitro. Nevertheless, mice implanted with B7. 1-transfected cells survived significantly longer than those in the control groups. Immunocytochemical analysis of the tumors showed that there was infiltration of a number of CD8+ T-cells and CD25+ activated T-cells in the brain implanted with B7.1-transfected glioma cells. The results showed the possibility that adenovirus-mediated B7.1 gene transfection to a brain tumor induced activation of CD8+ cytotoxic T-lymphocytes.
Asunto(s)
Astrocitoma/genética , Astrocitoma/inmunología , Antígeno B7-1/genética , Antígeno B7-1/inmunología , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/inmunología , Adenoviridae , Animales , Astrocitoma/metabolismo , Neoplasias Encefálicas/metabolismo , Linfocitos T CD8-positivos/inmunología , División Celular/genética , División Celular/inmunología , Citotoxicidad Inmunológica , Terapia Genética , Vectores Genéticos , Inmunohistoquímica , Inmunoterapia , Masculino , Ratones , Trasplante de Neoplasias/inmunología , Transfección , Células Tumorales CultivadasRESUMEN
A 29-year-old man and a 46-year-old woman presented with calcified brain metastasis from pulmonary adenocarcinoma. Both patients had a relatively benign clinical course and prolonged survival after total removal of the tumors. The male patient was still alive 2 years 3 months after surgical resection of the metastatic and primary tumors. The female patient had had brain metastasis 8 years after surgical resection of lung cancer, and survived for 3 years 3 months after removal of the brain metastasis. The MIB-1 indexes of the two cases were relatively low compared with other cases of brain metastases. Calcification and low MIB-1 index may indicate longer survival in patients with metastatic tumors if the primary tumor is controlled.
