Reapplication of the Pavlik Harness for Treatment of Developmental Dysplasia of the Hip After Initial Pavlik Harness Failure.

OBJECTIVE: The Pavlik harness (PH) has been widely used as the standard treatment for infants with developmental dysplasia of the hip (DDH). When the initial application of the PH fails, alternative treatments, such as closed reduction, open reduction, and reapplication of the PH will be considered. Compared with other treatments, reapplication of the PH offers certain advantages, including simplicity and reduced physical, and psychological stress, on both infants and caregivers. This study aims to investigate the effectiveness of reapplying the PH in patients with DDH. METHODS: This study included patients with DDH (complete dislocation) who were treated by reapplication of PH between 1988 and 2012. Patients who were able to follow-up for more than 5 years were included. We examined the reduction rate and several factors to identify indicators associated with successful reduction during reapplication, including age, sex, side of hip dislocation, and the presence of the Ortolani sign. At the final follow-up, hip development was assessed using the Severin classification, whereas avascular necrosis (AVN) was evaluated using the Kalamchi classification and the Salter criteria. RESULTS: A total of 56 patients (48 females and 8 males) and 57 hips were included in this study. The mean age at first and second application of PH was 4.2 months old (range: 0.12 to 6.4), and 5.8 months old (3.0 to 11.4), respectively. The reduction rate was 49% (28 out of 57 hips). Among the successfully reduced hips, the AVN rate was 3.6% (1 out of 28 hips). The Severin classification revealed 27 hips in class I and 1 hip in class III. Statistical analysis indicated a significantly higher proportion of left hip involvement in the reduction group (85% vs 41%, χ 2 test, P < 0.001). Although not statistically significant, the rate of positive Ortolani sign tended to be higher in the reduction group (61% vs 38%, χ 2 test, P = 0.06). CONCLUSION: The reapplication method demonstrated a 49% reduction rate and a low AVN rate of 3.6% in our study. It is worth considering for patients who fail the initial PH treatment, particularly in cases of left-side dislocation and a positive Ortolani sign during the initial application.

Experimental and quantitative evaluation of frequency modulation caused by Doppler effect around high-speed moving sound source.

High-speed train noise remains a wayside environmental issue. For accurate noise prediction, the characteristics of a moving sound source must be revealed. In this work, the frequency modulation of sound waves emitted from a high-speed moving sound source was experimentally investigated. In the experiment, the sound field around a running train model emitting a 40 kHz pure tone was measured by an optical measurement technique, parallel phase-shifting interferometry, which can visualize instantaneous sound fields. For quantitative evaluation, a lens distortion correction was also developed and adopted for the visualization results. From the measured result of a sound source moving at a running speed of 280 km/h, the frequency modulation, known as the Doppler effect, was observed, and the measured frequency agreed well with the theoretical values.

Radiologic Changes After 10 Years Postreduction in Developmental Dysplasia of the Hip Treated With Different Reduction Methods and Risk Factors for Osteoarthritis.

BACKGROUND: This study examined how radiologic indices at 10 years postreduction change over time and influence the final outcome through a comparative study of 3 reduction methods for developmental dysplasia of the hip, including the Pavlik harness, closed reduction, and open reduction (OR). METHODS: Patients treated from 1990 to 2000 for dysplasia of the hip and followed up for >20 years were included in this study. Radiologic indices at 10 years postreduction and final follow-up (average 24 years postreduction) were measured in the 3 groups. The relative joint space of <66% compared with the healthy side was defined as positive osteoarthritis (OA) at the final follow-up. The relationship between OA and factors such as age, sex, method of reduction, radiologic indices, and Severin and Kalamchi classifications at 10 years postreduction were examined. Clinical evaluation was performed using the modified Harris Hip Score; a score of ≥80 was defined as good performance at the final follow-up. RESULTS: Sixty-five patients (totaling 74 hips) were included. There were no significant differences in radiologic indices between the 10-year postreduction time and final follow-up. Excluding 9 bilateral patients, based on the relative joint space, 21% of the patients (13/56 hips), were positive for OA. Univariate analysis showed that the incidence of positive OA was significantly associated with OR and Kalamchi grade 4 at 10 years postreduction. The modified Harris Hip Score was 80 or higher in 90% of the cases at the final follow-up. CONCLUSIONS: No significant changes in hip morphology were observed at 10 years postreduction. The Kalamchi classification at 10 years postreduction and OR were significantly associated with the incidence of OA at the final follow-up. Therefore, patients who undergo OR and/or display Kalamchi grade 4 have a high risk of developing OA and would require individual instructions for their daily lives to prevent further progression of OA and longer follow-up. LEVEL OF EVIDENCE: Level Ⅲ-case-control study.

Determination of microphone acoustic center from sound field projection measured by optical interferometry.

This article presents a method for determining the acoustic center of a microphone from a sound field measured by optical interferometry. The acoustic center defines the equivalent point source position of a microphone serving as a sound source where the spherical waveform starts to diverge. The value is used to determine the effective distance between microphones for free-field reciprocity calibration. Conventionally, it is determined from the inverse distance law properties of a point source using the transfer function method. In this study, the acoustic center was determined from the projection of the sound field of the microphone. Parallel phase-shifting interferometry was used to measure the line integration of the sound pressure from a microphone. The acoustic center is determined as the position where the squared error between the measured data and the projection model of a point source is minimized. Experiments with the B&K 4180 (Brüel & Kjær, Nærum, Denmark) microphone were performed for frequencies from 10 to 50 kHz. The best acoustic center estimation was obtained at a microphone distance of 0 mm, with a difference of 0.17 mm to the IEC 61094-3 value and 0.36 mm to the Barrera-Figueroa et al. [J. Acoust. Soc. Am. 120(5), 2668-2675 (2006)] result at a measurement frequency of 20 kHz.

Speckle holographic imaging of a sound field using Fresnel lenses.

In this Letter, we propose to use Fresnel lenses for holographic sound-field imaging. Although a Fresnel lens has never been used for sound-field imaging mainly due to its low imaging quality, it has several desired properties, including thinness, lightweight, low cost, and ease of making a large aperture. We constructed an optical holographic imaging system composed of two Fresnel lenses used for magnification and demagnification of the illuminating beam. A proof-of-concept experiment verified that the sound-field imaging with Fresnel lenses is possible by using the spatiotemporally harmonic nature of sound.

Improvements in Intractable Lumbar and LowerExtremity Symptoms after Systemic Administration of Tocilizumab, an Anti-interleukin-6 Receptor Antibody.

STUDY DESIGN: Prospective cohort study (open-label, single-arm, and non-blinded). PURPOSE: This study aims to determine the effects of systemic administration of tocilizumab, an anti-interleukin-6 (IL-6) receptor antibody on refractory low back pain and leg symptoms. OVERVIEW OF LITERATURE: IL-6 overexpression is associated with neuropathic pain pathogenesis, which is potentially followed by chronic low back pain, including leg pain and numbness. This finding suggest that inhibition of IL-6 at the site of pain or in the transmission pathway could provide novel therapeutic targets for chronic low back pain. METHODS: This prospective, single-arm study included 11 patients (eight men; mean age, 62.7 years) with ≥3-months' chronic pain history due to lumbar disease. Subcutaneous TCZ injections were administered twice, at a 2-week interval. We evaluated low back pain, leg pain, and leg numbness using numeric rating scales and the Oswestry Disability Index (ODI; baseline and 6 months postinjection); serum IL-6 and tumor necrosis factor-α levels (baseline and 1 month postinjection); and clinical adverse events. RESULTS: Intractable symptoms reduced after TCZ administration. Low back pain improved for 6 months. Improvements in leg pain and numbness peaked at 4 and 1 month, respectively. Improvements in ODI were significant at 1 month and peaked at 4 months. Serum IL-6 was increased at 1 month. IL-6 responders (i.e., patients with IL-6 increases >10 pg/mL) showed particularly significant improvements in leg pain at 2 weeks, 1 month, and 2 months compared with nonresponders. We observed no apparent adverse events. CONCLUSIONS: Systemic TCZ administration improved symptoms effectively for 6 months, with peak improvements at 1-4 months and no adverse events. Changing serum IL-6 levels correlated with leg pain improvements; further studies are warranted to elucidate the mechanistic connections between lumbar disorders and inflammatory cytokines.

Diffusion Tensor Imaging of the Spinal Canal in Quantitative Assessment of Patients with Lumbar Spinal Canal Stenosis.

STUDY DESIGN: Retrospective observational study. PURPOSE: Lumbar spinal stenosis (LSS) has traditionally been evaluated morphologically, there is a paucity of literature on quantitative assessment of LSS. The purpose of this study was to investigate whether intraspinal diffusion tensor imaging (DTI) parameters such as apparent diffusion coefficient (ADC) and fractional anisotropy (FA) are useful for assessing LSS. OVERVIEW OF LITERATURE: Quantitative assessment of LSS is challenging. METHODS: Study participants comprised five healthy volunteers (mean age, 27.2 years) and 27 patients with LSS (mean age, 58.4 years) who were individually assessed using 3.0 Tesla magnetic resonance imaging. Intraspinal ADC and FA values of 10 intervertebral discs from healthy volunteers and 52 intervertebral discs from LSS patients were measured. Also, intraspinal canal area, Schizas classification (A: normal, B: mild stenosis, C: severe stenosis) and correlations with symptoms were investigated. Clinical symptoms were checked for the presence of low back pain (LBP), intermittent claudication (IMC), and bladder and bowel dysfunction (BBD). RESULTS: Compared to healthy individuals, LSS patients had significantly lower ADC (p<0.05) and significantly higher FA values (p<0.01). In Schizas classification, stenosis worsened from A to C. ADC values decreased significantly while FA values increased significantly in that order (p<0.05). A positive correlation was found between intraspinal canal area and ADC values (r=0.63, p<0.01) and a negative correlation between intraspinal canal area and FA values (p=-0.61, p<0.01). No correlations were noted between LBP and ADC or FA values. On the other hand, ADC values were significantly lower (p<0.05) and FA values were significantly higher (p<0.05) in patients with IMC or BBD. CONCLUSIONS: Intraspinal DTI parameters such as ADC and FA values were associated with the Schizas classification, intraspinal canal area, and clinical symptoms, suggesting that ADC and FA may be useful for quantitative assessment of LSS.

Seeing the sound of castanets: Acoustic resonances between shells captured by high-speed optical visualization with 1-mm resolution.

Sound fields radiated from the castanet, a Spanish percussive instrument comprising two shells, were optically visualized. A measurement system, which used parallel phase-shifting interferometry and a high-speed polarization camera, enabled the capture of instantaneous sound fields around the castanets, while the castanets were played, with the spatial resolution of 1.1 mm and frame rate of 100 000 fps. By carefully aligning the tilt of the castanets, the sound fields within the 1-mm gaps between both the shells were captured. From the visualization results, two acoustic resonances between the shells were identified. The first mode appeared between 1000 and 2000 Hz and exhibited a frequency chirp of several hundred hertz for several milliseconds after the impact. This can be explained by the Helmholtz resonance with a time-varying resonator shape, which is caused by the movement of the shells after impact. The second mode showed a resonance pattern with a single nodal diameter at the center of the shells, i.e., the standing wave mode caused by the interior volume. These physical phenomena involved in the sound radiation were identified owing to the unique features of the optical imaging method, such as contactless nature and millimeter-resolution imaging of instantaneous pressure fields.

Evaluating Spinal Canal Lesions Using Apparent Diffusion Coefficient Maps with Diffusion-Weighted Imaging.

STUDY DESIGN: Observational study. PURPOSE: To evaluate healthy volunteers and patients with spinal canal lesions using apparent diffusion coefficient (ADC) maps with diffusion-weighted imaging. OVERVIEW OF LITERATURE: Decompression surgery for lumbar spinal stenosis (LSS) is selected on the basis of subjective assessment and cross-sectional magnetic resonance imaging (MRI). However, there is no objective standard for this procedure. METHODS: We performed 3T MRI in 10 healthy volunteers and 13 patients with LSS. The ADC values in the spinal canal were evaluated at 46 vertebrae (L4/5 and L5/S1 for each participant), and the reduced and conventional fields of view were compared. RESULTS: The ADC values were 2.72±0.12 at L4/5 in healthy volunteers, 2.76±0.19 at L5/S1 in healthy volunteers, 1.77±0.58 at L4/5 in patients with LSS, and 2.35±0.29 at L5/S1 in patients with LSS. The ADC value at L4/5 in patients with LSS was significantly lower than that at L5/S1 in patients with LSS and that at L4/5 and L5/S1 in healthy volunteers (p <0.05). With an ADC cutoff value of 2.46 to identify LSS, this approach provided an area under the curve of 0.81, sensitivity of 0.92, and specificity of 0.76 (p <0.05). CONCLUSIONS: Preoperative examination using ADC maps permits visualization and quantification of spinal canal lesions, thus proving the utility of ADC maps in the selection of decompression surgery for LSS.

Radiological results of Shelf acetabuloplasty in adolescent hip dysplasia with aspherical femoral head: how to get an ideal placement of the Shelf graft.

Shelf acetabuloplasty continues to be effective in the prevention or delay of osteoarthritis in adolescent dysplastic hips. We aimed to evaluate the efficacy and to determine the correct level of the bone graft objectively. We retrospectively analyzed 16 hips underwent Shelf acetabuloplasty originated by Spitzy. The mean age at surgery was 15.3 years old with the mean caput index at 39.7%. The average follow-up was 11 years. The radiological evaluation was based on acetabular-head index (AHI) at preoperative and latest radiographs, acetabular-Shelf distance (ASD) and Shelf-head ratio at immediate postoperative and latest radiographs. The cutoff value for the ideal ASD was determined by receiver operating characteristic (ROC) and the Pearson correlation test used in statistical analysis to assess the relationship between ASD and Shelf graft resorption. Clinical evaluation was performed using Harris Hip Score (HHS) at the latest follow-up. The AHI was improved in all cases, from mean 56.9 to 91.0% (P < 0.001). The mean of ASD was 7 mm. In nine of the 16 cases, the Shelf graft was well united at the same level of the existing acetabulum with good continuity. The ROC curve showed the cutoff value for the ideal ASD was 6 mm. The Pearson correlation test also showed a positive relationship between ASD and Shelf graft resorption (P = 0.001). The average of HHS scores was 98.1 points. Both radiological and clinical results were acceptable. The ideal placement that keeps the shelf sufficient to bear the mechanical stress without bone resorption over time was at the level of 6 mm from the joint space. Level III - therapeutic study.

Source directivity approximation for finite-difference time-domain simulation by estimating initial value.

In order to incorporate a directive sound source into acoustic simulation using the finite-difference time-domain method (FDTD), this paper proposes an optimization-based method to estimate the initial value which approximates a desired directional pattern after propagation. The proposed method explicitly considers a discretized FDTD scheme and optimizes the initial value directly in the time domain so that every effect of the discretization error of FDTD, including numerical dispersion, is taken into account. It is also able to consider a frequency-wise directivity by integrating the Fourier transform into the optimization procedure, even though the estimated result is defined in the time domain. After the optimization, the obtained result can be utilized in any acoustic simulation based on the same FDTD scheme without modification because the result is represented as the initial value to be propagated and no additional procedure is required.

Platelet-rich plasma enhances bone union in posterolateral lumbar fusion: A prospective randomized controlled trial.

BACKGROUND CONTEXT: Platelet-rich plasma (PRP) accelerates bone union in vivo in a rodent model of spinal fusion surgery. However, PRP's effect on bone union after spinal surgery remains unclear. PURPOSE: The objective of this study was to evaluate the efficacy of PRP after posterolateral lumbar fusion (PLF) surgery. STUDY DESIGN/SETTING: Single-center prospective randomized controlled clinical trial with 2-year follow-up. PATIENT SAMPLE: The patient sample included a total 62 patients (31 patients in the PRP group or 31 patients in the control group). OUTCOME MEASURES: The outcome measures included the bone fusion rate, the area of bone fusion mass, the duration of bone fusion, and the clinical score using the visual analog scale (VAS). MATERIALS AND METHODS: We randomized 62 patients who underwent one- or two-level instrumented PLF for lumbar degenerative spondylosis with instability to either the PRP (31 patients) or the control (31 patients) groups. Platelet-rich plasma-treated patients underwent surgery using an autograft bone chip (local bone), and PRP was prepared from patient blood samples immediately before surgery; patients from the control group underwent PLF without PRP treatment. We assessed platelet counts and growth factor concentrations in PRP prepared immediately before surgery. The duration of bone union, the postoperative bone fusion rate, and the area of fusion mass were assessed using plain radiography every 3 months after surgery and by computed tomography at 12 or 24 months. The duration of bone fusion and the clinical scores for low back pain, leg pain, and leg numbness before and 3, 6, 12, and 24 months after surgery were evaluated using VAS. RESULTS: Data from 50 patients with complete data were included. The bone union rate at the final follow-up was significantly higher in the PRP group (94%) than in the control group (74%) (p=.002). The area of fusion mass was significantly higher in the PRP group (572 mm2) than in the control group (367 mm2) (p=.02). The mean period necessary for union was 7.8 months in the PRP group and 9.8 months in the control group (p=.013). In the PRP, the platelet count was 7.7 times higher and the growth factor concentrations were 50 times higher than those found in plasma (p<.05). There was no significant difference in low back pain, leg pain, and leg numbness in either group at any time evaluated (p>.05). CONCLUSIONS: Patients treated with PRP showed a higher fusion rate, greater fusion mass, and more rapid bone union after spinal fusion surgery than patients not treated with PRP.

Optical visualization of a fluid flow via the temperature controlling method.

In this Letter, a visualization method of a fluid flow through temperature control is proposed. The proposed method enables us to visualize an invisible fluid flow by controlling the temperature so that its visibility can be easily adjusted. Such ability of adjusting appearance is effective for visualizing the phenomena consisting of multiple physical processes. In order to verify the validity of the proposed method, the measurement experiment of visualization of both flow and sound in air using parallel phase-shifting interferometry, which is a similar condition to the previous research [Opt. Lett.43, 991 (2018)OPLEDP0146-959210.1364/OL.43.000991], was conducted.

Time-directional filtering of wrapped phase for observing transient phenomena with parallel phase-shifting interferometry.

Recent development of parallel phase-shifting interferometry (PPSI) enables accurate measurement of time-varying phase maps. By combining a high-speed camera with PPSI, it became possible to observe not only time-varying but also fast phenomena including fluid flow and sound in air. In such observation, one has to remove static phase (time-invariant or slowly-varying phase unrelated to the phenomena of interest) from the observed phase maps. Ordinarily, a signal processing method for eliminating the static phase is utilized after phase unwrapping to avoid the 2π discontinuity which can be a source of error. In this paper, it is shown that such phase unwrapping is not necessary for the high-speed observation, and a time-directional filtering method is proposed for removing the static phase directly from the wrapped phase without performing phase unwrapping. In addition, experimental results of simultaneously visualizing flow and sound with 42 000 fps are shown to illustrate how the time-directional filtering changes the appearance. A MATLAB code is included within the paper (also in https://goo.gl/N4wzdp) for aiding the understanding of the proposed method.

Simultaneous imaging of flow and sound using high-speed parallel phase-shifting interferometry.

In this Letter, simultaneous imaging of flow and sound by using parallel phase-shifting interferometry and a high-speed polarization camera is proposed. The proposed method enables the visualization of flow and sound simultaneously by using the following two factors: (i) injection of the gas, whose density is different from the surrounding air, makes the flow visible to interferometry, and (ii) time-directional processing is applied for extracting the small-amplitude sound wave from the high-speed flow video. An experiment with a frame rate of 42,000 frames per second for visualizing the flow and sound emitted from a whistle was conducted. By applying time-directional processing to the obtained video, both flow emitted from the slit of the whistle and a spherical sound wave of 8.7 kHz were successively captured.

Single Versus Combined Procedures for Severely Involved Legg-Calvé-Perthes Disease.

BACKGROUND: The concept of containment as an effective approach to reduce the risk of femoral head deformity has been questioned because modest results have been achieved after nonoperative and operative treatments for severely involved Legg-Calvé-Perthes disease. Several reports have shown the limited effectiveness of some conventional single procedures. However, there is limited data on the effectiveness of combined procedures. METHODS: The surgical group comprised 77 patients (mean age 8.3 y) and involved 79 hips. The average follow-up term was 9.5 years. Sixty-five patients were unilaterally involved and 12 patients were bilaterally involved (although 10 of the latter patients only received surgery on 1 hip). Among patients, 28 hips were classified as Herring class B/C border (>8 y old) and 51 hips were Herring class C. The 79 hips were divided into 2 treatment groups for further analysis: group 1, single procedures (femoral varus osteotomy) (n=47); group 2, combined procedures [femoral varus osteotomy+Dega (Pemberton) osteotomy] (n=32). RESULTS: Using Stulberg classification I and II (acceptable outcome), the final outcome was statistically significant for group 2 (21 hips, 65.6%) compared with group 1 (18 hips, 38.3%) (P=0.031). The average remodeling efficacy, defined as the change in caput index between preoperation and postoperation, was better in group 2 (12.7%) than in group 1 (3.9%) (P=0.005). The acetabulum-head index and α-angle were also statistically significant in group 2 than in group 1 at the last follow-up. Clinical evaluations were statistically significant in group 2 compared with group 1. CONCLUSIONS: Both clinically and radiologically, the combined procedure group demonstrated significantly better outcomes with accelerated remodeling in both the severely affected femoral heads and the acetabula compared with the single procedure group. With this procedure, we anticipate the increased likelihood of preventing or delaying coxarthroses in adulthood. LEVEL OF EVIDENCE: Level III-therapeutic study.

Vascular endothelial growth factor in degenerating intervertebral discs of rat caudal vertebrae.

INTRODUCTION: Discogenic back pain remains poorly understood with respect to etiopathogenesis, despite being a considerable burden. We sought to examine the expression of vascular endothelial growth factor in injured intervertebral discs in rat caudal vertebrae. METHODS: Forty-eight male Sprague Dawley rats were assigned to 2 groups according to disc puncture injury: puncture (n = 32) or non-puncture (n = 16). Disc puncture was performed percutaneously such that the incision would be in the primary plane of motion for the coccygeal discs 5-6, 6-7, and 7-8. A 26-gauge needle was used to puncture each disc 10 times. Punctured discs were examined histologically by hematoxylin and eosin staining at 1, 7, 14, and 28 days post-injury. RESULTS: Vascular endothelial growth factor was localized immunohistochemically, and determined quantitatively using an enzyme-linked immunosorbent assay. Peak inflammation occurred on the 7th day post-injury, but tissue degeneration continued until day 28. Local expression of vascular endothelial growth factor tended to be highest in the annulus fibrosus on the 7th and 14th days after puncture injury. The level of vascular endothelial growth factor was highest 1-day post-injury, and then gradually decreased thereafter. Furthermore, vascular endothelial growth factor levels in the puncture group were significantly higher than those in the non-puncture control group (p < 0.05). CONCLUSIONS: We found increased expression of the inflammatory cytokine vascular endothelial growth factor in injured intervertebral discs, suggesting that vascular endothelial growth factor may be clinically important in discogenic back pain.