RESUMEN
BACKGROUND: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. OBJECTIVE: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). METHODS: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scoring (ISS) was measured for all patients. RESULTS: The results of this study indicated that there was a significant relationship between the level of IL-6 and ISS on the first and second days post trauma (P=0.0001). The high level of IL-6 on the second day post trauma was associated with high mortality rate. CONCLUSION: Our study suggests the second day as the golden time for measuring the serum levels of IL-6. These findings warn us to take more health care actions in patients with higher serum levels of IL-6 on the second day.
Asunto(s)
Interleucina-6/sangre , Insuficiencia Multiorgánica/sangre , Insuficiencia Multiorgánica/mortalidad , Enfermedades Musculoesqueléticas/sangre , Enfermedades Musculoesqueléticas/mortalidad , Adolescente , Adulto , Anciano , Biomarcadores , Femenino , Humanos , Mediadores de Inflamación/sangre , Puntaje de Gravedad del Traumatismo , Masculino , Persona de Mediana Edad , Insuficiencia Multiorgánica/diagnóstico , Enfermedades Musculoesqueléticas/diagnóstico , Pronóstico , Factores de Tiempo , Tomografía Computarizada por Rayos X , Índices de Gravedad del Trauma , Adulto JovenRESUMEN
OBJECTIVE: The aim of this study was to analyze the effect of intramedullary nailing (IMN), open plating and percutaneous plating on the induction of IL-6 in patients with tibia fractures. METHODS: A total of 30 patients with tibia shaft fracture underwent either intramedullary nailing (IMN, n = 15; 14 males and 1 female; mean age: 32.1 ± 15.6), ORIF plating (n = 8; 5 males and 3 females; mean age: 60.0 ± 17.8), or percutaneous plating (n = 7; 6 males and 1 female; mean age: 43.1 ± 21.4). Serum IL-6 cytokine levels were measured prior to, and 6 and 24 h after the surgery, using a special ELISA kit. RESULTS: The IL-6 concentration increased to peak levels at 6 h in both IMN and percutaneous plating groups, and at 24 h in ORIF plating group (p < 0.001). The mean IL-6 concentration of percutaneous plating group was significantly lower than that of the IMN group at 6 h following the surgery (p = 0.022). In addition, the mean IL-6 concentration of ORIF plating group was significantly higher than that of the percutaneous plating group at 24 h post operation (p = 0.009). CONCLUSION: Our results suggest that percutaneous plating compared to the IMN has lower effects on IL-6 production in patients with tibia fracture. LEVEL OF EVIDENCE: Level III, therapeutic study.
