Mpox (monkeypox) risk and mortality associated with HIV infection: a national case-control study in Nigeria.

INTRODUCTION: Recent outbreaks of mpox are characterised by changes in the natural history of the disease, the demographic and clinical characteristics of the cases, and widening geographical distribution. We investigated the role of HIV and other sexually transmitted infections (STIs) coinfection among cases in the re-emergence of mpox to inform national and global response. METHODS: We conducted a national descriptive and case-control study on cases in the 2017-2019 Nigerian mpox outbreak. Mpox cases were age, sex and geographical area matched each with two randomly selected controls from a representative national HIV/AIDS survey. Logistic regression was used to investigate the association between HIV infection and the risk of mpox acquisition and death. RESULTS: Among 204 suspected mpox cases, 86 were confirmed (median age 31 years (IQR 27-38 years), mostly males (61 cases, 70.9%). Three-fifths of mpox cases had serological evidence of one or more STIs with 27.9% (24/86) coinfected with HIV. The case fatality rate was 9.4% (8/86) and 20.8% (5/24) overall and in HIV positive cases respectively. Mpox cases were more likely to have HIV coinfection compared with an age, gender and geography-matched control group drawn from the general population (OR 45 (95% CI 6.1 to 333.5, p=0.002) and when compared with non mpox rash cases (7.29 (95% CI 2.6 to 20.5, p<0.0001)). HIV coinfection and young age were associated with mortality among mpox cases (aOR 13.66 (95% CI 1.88 to 98.95, p=0.010) and aOR 0.90 (0.82-0.97, p=0.008), respectively). CONCLUSION: HIV infection was associated with a higher risk of contracting and dying from mpox. Children are also at high risk of death. STIs in mpox cases may be suggestive of high-risk sexual behaviours among these individuals.

Comprehensive assessment on the applications of oncolytic viruses for cancer immunotherapy.

The worldwide burden of cancers is increasing at a very high rate, including the aggressive and resistant forms of cancers. Certain levels of breakthrough have been achieved with the conventional treatment methods being used to treat different forms of cancers, but with some limitations. These limitations include hazardous side effects, destruction of non-tumor healthy cells that are rapidly dividing and developing, tumor resistance to anti-cancer drugs, damage to tissues and organs, and so on. However, oncolytic viruses have emerged as a worthwhile immunotherapeutic option for the treatment of different types of cancers. In this treatment approach, oncolytic viruses are being modeled to target cancer cells with optimum cytotoxicity and spare normal cells with optimal safety, without the oncolytic viruses themselves being killed by the host immune defense system. Oncolytic viral infection of the cancer cells are also being genetically manipulated (either by removal or addition of certain genes into the oncolytic virus genome) to make the tumor more visible and available for attack by the host immune cells. Hence, different variants of these viruses are being developed to optimize their antitumor effects. In this review, we examined how grave the burden of cancer is on a global level, particularly in sub-Saharan Africa, major conventional therapeutic approaches to the treatment of cancer and their individual drawbacks. We discussed the mechanisms of action employed by these oncolytic viruses and different viruses that have found their relevance in the fight against various forms of cancers. Some pre-clinical and clinical trials that involve oncolytic viruses in cancer management were reported. This review also examined the toxicity and safety concerns surrounding the adoption of oncolytic viro-immunotherapy for the treatment of cancers and the likely future directions for researchers and general audience who wants updated information.

Efficient removal of antibiotics from water resources is a public health priority: a critical assessment of the efficacy of some remediation strategies for antibiotics in water.

This review discusses the fundamental principles and mechanism of antibiotic removal from water of some commonly applied treatment techniques including chlorination, ozonation, UV-irradiation, Fenton processes, photocatalysis, electrochemical-oxidation, plasma, biochar, anaerobicdigestion, activated carbon and nanomaterials. Some experimental shortfalls identified by researchers such as certain characteristics of degradation agent applied and the strategies explored to override the identified limitations are briefly discussed. Depending on interactions of a range of factors including the type of antibiotic compound, operational parameters applied such as pH, temperature and treatment time, among other factors, all reviewed techniques can eliminate or reduce the levels of antibiotic compounds in water to varying extents. Some of the reviewed techniques such as anaerobic digestion generally require longer treatment times (up to 360, 193 and 170 days, according to some studies), while others such as photocatalysis achieved degradation within short contact time (within a minimum of 30, but up to 60, 240, 300 and 1880 minutes, in some cases). For some treatment techniques such as ozonation and Fenton, it is apparent that subjecting compounds to longer treatment times may improve elimination efficiency, whereas for some other techniques such as nanotechnology, application of longer treatment time generally meant comparatively minimal elimination efficiency. Based on the findings of experimental studies summarized, it is apparent that operational parameters such as pH and treatment time, while critical, do not exert sole or primary influence on the elimination percentage(s) achieved. Elimination efficiency achieved rather seems to be due more to the force of a combination of several factors.