Hygienic signs of diagnostics of early dysmetabolic disorders symptoms.

OBJECTIVE: The aim of the study was to identify certain health features among healthy people that can serve as a risk factor and lead to the further development of metabolic syndrome. PATIENTS AND METHODS: Materials and methods: A total of 79 men, completely health, were interviewed during 2019 at the Center for Health and Longevity Technology (Kyiv) to assess their health and further correction recommendations for identified abnormalities and available changes. The mean age of men was (37.18 ± 0.89) years. Non-invasive methods were used in the study: determination of anthropometric parameters - height, body weight, waist circumference, abdomen, index of ratio of waist-to-waist circumference, body mass index, body shape index. The constituent compositions of the body were performed with an InBody 220 apparatus with impedance analysis. The metabolic profile was evaluated using FITMATE, a portable metabological device. The cardiovascular profile was determined in the CARDIOLAB + HRV system. The obtained digital data were processed by the method of variational statistics using Microsoft Excel 7.0. RESULTS: Results: It was found that in 44 (54.4%) of the surveyed men, the waist circumference exceeded 94 cm. The largest number of such persons was found among men aged 31-40 years - (29.11% of the surveyed in this group) and persons aged 41-50 years - 21.52%. Fat distribution (waist circumference / hip circumference) averaged (0.83 ± 0.02). The difference in the body shape index between the group of young persons and groups of older men was established. The predisposition to metabolic disorders is established in 49,37% of cases. Determination of metabolic profile revealed a deviation toward an increase in actual metabolism in 15 people and 15 - in the direction of reducing it. CONCLUSION: Conclusions: Thus, the results of a thorough examination of healthy men showed that they may have health changes that characterize the early signs of disease risk, and their presence can be detected by simple non-invasive research methods. The doctor's task is to assign an in-depth study of the risk factors for the development of a particularly common in our time prevalence of a complex multicomponent metabolic syndrome, which includes the symptoms of the defeat of many body systems, in particular, the endocrine, cardiovascular, urinary and other in order to preserve human health and to recognize it as early as possible, prevent it and avoid complications.

Experimental study on the carcinogenic effects of pesticides with ascertained carcinogenic activity under the conditions of its simultaneous influence on the organism of laboratory animals.

OBJECTIVE: Introduction: It is known that pesticides have both short-term and long-term effects of the action on the human body. Today, taking into account the growth rate of the agricultural crops protection means' market and the expansion of the range of pesticide mixtures and combined formulations, there is a need for a more in-depth study of its possible effects on the environment and the human body. Recently, a new fungicide containing a mixture of two active substances, benthiavalicarb isopropyl and folpet, was introduced for application in Ukraine. Considering the possible influence of both substances on the enzyme systems involved in the xenobiotic metabolism, potentiation of its carcinogenic action in the formulation can be expected. No genotoxic effect was revealed studying in vivo studies the mutagenic activity of both substances isolated. Therefore, both substances are epigenetic carcinogens with a promoter threshold mechanism of action. In this regard, the promoter action of these substances was studied by us in the mid-term test on a multi-organ model. The aim: The purpose of our work was an experimental study of the carcinogenic action of benthiavalicarb-isopropyl and folpet - substances with ascertained carcinogenic activity, under the conditions of its simultaneous influence on the organism of laboratory animals (rats and mice). PATIENTS AND METHODS: Materials and methods: Toxicological, toxicometric (weight of animals, absolute, relative mass of internal organs) histological, microscopic, histochemical, and statistical methods were used in the study. RESULTS: Results and conclusions: No combined action of folpet and benthiavalicarb-isopropyl on the proliferation of carcinogen-transformed hepatocytes and the formation of hyperplastic nodules expressing γ-glutamyltranspeptidases (γ-GTP) as markers of pre-tumor changes in hepatocarcinogenesis was revealed. This allows us to conclude that there is no modifying effect of the folpet on carcinogenicity.