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Mioclonía , Atrofias Musculares Espinales de la Infancia , Humanos , Atrofias Musculares Espinales de la Infancia/complicaciones , Atrofias Musculares Espinales de la Infancia/diagnóstico , Masculino , Mioclonía/etiología , Mioclonía/diagnóstico , Imagen por Resonancia Magnética , ElectromiografíaAsunto(s)
Astrocitos , Enfermedades Gastrointestinales , Humanos , Autoanticuerpos , Inmunoglobulina GRESUMEN
BACKGROUND: Stroke patients have a redox imbalance, a consequence of both the cerebrovascular event and the associated pathological conditions. Our study was aimed to investigate the dynamic of some oxidative and nitrosative markers during the convalescent phase of postacute stroke patients undergoing rehabilitation. METHODS: We assessed thiol, advanced oxidation protein product, protein carbonyl, 3-nitro-l-tyrosine, ceruloplasmin and oxidized LDL concentrations, as well as gamma-glutamyltranspeptidase (GGT) activity in 20 patients at the beginning of the hospitalization and at the discharge moment, respectively, and 24 apparently healthy controls. RESULTS: We found significantly increased values for GGT (P = 0.04), ceruloplasmin (P = 0.01) and protein carbonyl (P = 0.04) in stroke patients at the hospitalization moment when compared with healthy controls, while total thiols were significantly decreased (P = 0.002). Rehabilitation was associated with a significant decrease of protein carbonyl (P = 0.03) and oxidized LDL particle concentrations (P = 0.03), as well as GGT activity (P = 0.02). At the hospitalization moment, both GGT and ceruloplasmin were significantly negatively correlated with non-proteic thiols (r = -0.44, P = 0.049, and r = -0.53, P = 0.015, respectively) and significantly positively with protein carbonyls (r = +0.80, P < 0.001, and r = +0.69, P < 0.001, respectively) suggesting putative roles of GGT and ceruloplasmin in the redox imbalance. CONCLUSIONS: These results highlight the existence of a redox imbalance in postacute stroke patients, and the possible benefits of an antioxidant-based therapy for the recovery of these patients.
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Nitrógeno/metabolismo , Estrés Oxidativo , Rehabilitación de Accidente Cerebrovascular , Accidente Cerebrovascular/sangre , Anciano , Biomarcadores/sangre , Ceruloplasmina/análisis , Convalecencia , Femenino , Humanos , Masculino , Persona de Mediana Edad , Oxidación-Reducción , Compuestos de Sulfhidrilo/sangre , gamma-Glutamiltransferasa/sangreRESUMEN
alpha-Tocopherol belongs to the group of vitamin E vitamers. Recent years findings indicate that alpha-tocopherol is more than just a simple fat-soluble anti-oxidant as it was found that it can also regulate gene expression. From all vitamin E vitamers human body preferentially retains alpha-tocopherol, but the reasons for this preference are still elusive. Different studies indicated that human body, through the action of two hepatic proteins, alpha-tocopherol transfer protein (alpha-TTP) and cytochrome P450 4F2 (CYP4F2), is able to make subtle structural differences between different vitamin E forms. This is an example of stereochemistry used as a discrimination factor between molecules with different biological activities.
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alfa-Tocoferol/metabolismo , Antioxidantes/metabolismo , Proteínas Portadoras/metabolismo , Sistema Enzimático del Citocromo P-450/metabolismo , Familia 4 del Citocromo P450 , Humanos , EstereoisomerismoRESUMEN
The authors present a case of ethmo-spheno-maxillary mucocele revealed by the appearance of a giant unilateral exophthalmia with an important decrease of visual acuity and spectacular regression of symptomatology after surgical excision. We must note the initial location near the tear ductus, the slow progression (12 years) with a false aspect of chronic dacryocystitis.