Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 16 de 16
Filtrar
1.
Clin Spine Surg ; 37(4): 170-177, 2024 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-38637924

RESUMEN

STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To compare the frequency of complications and outcomes between patients with ossification of the posterior longitudinal ligament (OPLL) of the cervical spine and those with cervical spondylotic myelopathy (CSM) who underwent anterior surgery. SUMMARY OF BACKGROUND DATA: Anterior cervical spine surgery for OPLL is an effective surgical procedure; however, it is complex and technically demanding compared with the procedure for CSM. Few reports have compared postoperative complications and clinical outcomes after anterior surgeries between the 2 pathologies. METHODS: Among 1434 patients who underwent anterior cervical spine surgery at 3 spine centers within the same spine research group from January 2011 to March 2021, 333 patients with OPLL and 488 patients with CSM were retrospectively evaluated. Demographics, postoperative complications, and outcomes were reviewed by analyzing medical records. In-hospital and postdischarge postoperative complications were investigated. Postoperative outcomes were evaluated 1 year after the surgery using the Japanese Orthopaedic Association score. RESULTS: Patients with OPLL had more comorbid diabetes mellitus preoperatively than patients with CSM ( P <0.001). Anterior cervical corpectomies were more often performed in patients with OPLL than in those with CSM (73.3% and 14.5%). In-hospital complications, such as reoperation, cerebrospinal fluid leak, C5 palsy, graft complications, hoarseness, and upper airway complications, occurred significantly more often in patients with OPLL. Complications after discharge, such as complications of the graft bone/cage and hoarseness, were significantly more common in patients with OPLL. The recovery rate of the Japanese Orthopaedic Association score 1 year postoperatively was similar between patients with OPLL and those with CSM. CONCLUSION: The present study demonstrated that complications, both in-hospital and after discharge following anterior spine surgery, occurred more frequently in patients with OPLL than in those with CSM.


Asunto(s)
Vértebras Cervicales , Osificación del Ligamento Longitudinal Posterior , Complicaciones Posoperatorias , Espondilosis , Humanos , Osificación del Ligamento Longitudinal Posterior/cirugía , Osificación del Ligamento Longitudinal Posterior/complicaciones , Masculino , Complicaciones Posoperatorias/etiología , Femenino , Vértebras Cervicales/cirugía , Persona de Mediana Edad , Espondilosis/cirugía , Espondilosis/complicaciones , Resultado del Tratamiento , Anciano , Estudios Retrospectivos , Enfermedades de la Médula Espinal/cirugía
2.
Global Spine J ; : 21925682231196449, 2023 Aug 18.
Artículo en Inglés | MEDLINE | ID: mdl-37596769

RESUMEN

STUDY DESIGN: A multi-institutional retrospective study. OBJECTIVES: To investigate risk factors of mechanical failure in three-column osteotomy (3COs) in patients with adult spinal deformity (ASD), focusing on the osteotomy level. METHODS: We retrospectively reviewed 111 patients with ASD who underwent 3COs with at least 2 years of follow-up. Radiographic parameters, clinical data on early and late postoperative complications were collected. Surgical outcomes were compared between the low-level osteotomy group and the high-level osteotomy group: osteotomy level of L3 or lower group (LO group, n = 60) and osteotomy of L2 or higher group (HO group, n = 51). RESULTS: Of the 111 patients, 25 needed revision surgery for mechanical complication (mechanical failure). A lower t-score (odds ratio [OR] .39 P = .002) and being in the HO group (OR 4.54, P = .03) were independently associated with mechanical failure. In the analysis divided by the osteotomy level (LO and HO), no difference in early complications or neurological complications was found between the two groups. The rates of overall mechanical complications, rod failure, and mechanical failure were significantly higher in the HO group than in the LO group. After propensity score matching, mechanical complications and failures were still significantly more observed in the HO group than in the LO group (P = .01 and .029, respectively). CONCLUSIONS: A lower t-score and osteotomy of L2 or higher were associated with increased risks of mechanical failure. Lower osteotomy was associated with better correction of sagittal balance and a lower rate of mechanical complications.

3.
J Orthop Sci ; 28(3): 515-520, 2023 May.
Artículo en Inglés | MEDLINE | ID: mdl-35227539

RESUMEN

BACKGROUND: There are few reports concerning determinants of the surgical outcome of anterior decompression and fusion (ADF) when performed for ossification of the posterior longitudinal ligament of the thoracic spine (T-OPLL). We investigated prognostic factors associated with neurological recovery in the patients with T-OPLL. METHODS: This retrospective study included consecutive cases of T-OPLL patients from January 2002 to January 2020 and minimum one-year follow-up. Data were collected for sex, age, body mass index, preoperative manual muscle test score for the weakest muscle, surgical data, and preoperative and postoperative findings on radiographs, magnetic resonance images, and computed tomography scans. Imaging data were also collected, including preoperative kyphotic angles, canal occupancy ratio, type of OPLL, and high-intensity areas on T2-weighted images. The Japanese Orthopaedic Association score for thoracic myelopathy (T-JOA) was used to evaluate the recovery of the thoracic myelopathy. The patients were categorized according to whether the improvement in T-JOA score was >50% or ≤50%. RESULTS: Forty-six patients who underwent anterior procedures for T-OPLL were included in the study. Preoperative and postoperative T-JOA scores were 4.2 ± 2.3 and 7.9 ± 2.1, respectively. The improvement in the T-JOA score was 54.5 ± 25.6%. The proportion of patients with beak-type OPLL was significantly higher in the >50% JOA improvement group (23/27) than in the ≤50% group (9/19) (p = 0.009) and the canal occupancy ratio was significantly lower in the >50% group (56.3 ± 12.2% vs 64.4 ± 8.73%; p = 0.0163). There were no significant between-group differences in other factors. CONCLUSIONS: Beak-type ossification and a low canal occupancy ratio are predictors of good outcome after ADF in patients with T-OPLL. ADF should be considered in patients with either or both of these features.


Asunto(s)
Osificación del Ligamento Longitudinal Posterior , Enfermedades de la Médula Espinal , Fusión Vertebral , Animales , Humanos , Ligamentos Longitudinales , Estudios Retrospectivos , Osteogénesis , Resultado del Tratamiento , Osificación del Ligamento Longitudinal Posterior/diagnóstico por imagen , Osificación del Ligamento Longitudinal Posterior/cirugía , Osificación del Ligamento Longitudinal Posterior/complicaciones , Descompresión Quirúrgica/métodos , Fusión Vertebral/métodos , Enfermedades de la Médula Espinal/cirugía , Vértebras Cervicales/cirugía , Vértebras Torácicas/diagnóstico por imagen , Vértebras Torácicas/cirugía
4.
J Orthop Sci ; 28(2): 302-307, 2023 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-34924249

RESUMEN

BACKGROUND: Factors related to postoperative mechanical failure after long fusion with lower instrumented vertebra (LIV) at L5 have not been well investigated. Elucidating such factors may allow us to perform alternatives to spinopelvic fusion for adult spinal deformity (ASD) cases. We investigated the incidence and risk factors of LIV failure in patients with ASD who underwent surgical treatment of long corrective fusion until the L5 vertebrae. METHODS: Between 2009 and 2018, 52 patients who underwent corrective fusions to L5 were followed-up for at least one-year. We evaluated the associated patient factors for LIV failure which include loosening of the pedicle screw of LIV, fracture of LIV, distal junctional kyphosis (DJK). RESULTS: The mean age of the participants was 71.2 ± 7.59 (range, 44-84). LIV failure occurred in 20 patients (38.5%), and 6 patients (11.5%) underwent secondary surgery for caudal segments. The mean pelvic incidence (PI) was 52.5 ± 9.8 in the failure group versus 45.3 ± 11.4 in non-failure group (P = 0.02) and pelvic tilt (PT) was 39.1 ± 9.0 versus 32.4 ± 13.0. There were no significant differences in sex, age, body mass index, number of levels fused, and other radiographic data. Logistic regression analysis that included T1 pelvic angle, PT, PI - postoperative LL and PI also identified PI as the only significant determinant of LIV failure (OR = 1.07, P = 0.034). Receiver operating characteristic analysis demonstrated that a PI over 50.0° was associated with LIV failure (sensitivity 63%, specificity 70%, AUC 0.694). CONCLUSION: LIV failure was frequently observed after long corrective fusion for patients with ASD. High PI was found to be a significant risk factor for the LIV failure.


Asunto(s)
Cifosis , Tornillos Pediculares , Fusión Vertebral , Humanos , Adulto , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Vértebras Lumbares/cirugía , Cifosis/cirugía , Factores de Riesgo , Tornillos Pediculares/efectos adversos , Estudios Retrospectivos , Fusión Vertebral/efectos adversos , Vértebras Torácicas/cirugía
5.
J Orthop Sci ; 27(1): 89-94, 2022 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-33468342

RESUMEN

BACKGROUND: Several studies have reported that overweightness and obesity are associated with higher complication rates in lumbar spine surgery. However, little is known about the effect of obesity on postoperative complications in adult spinal deformity (ASD) surgery, especially in the elderly. This study aimed to examine the effect of body mass index (BMI) on surgical outcomes and postoperative complications in elderly ASD patients undergoing surgical correction in Japan. METHODS: We conducted a retrospective, multicenter, observational study of 234 consecutive patients diagnosed with ASD who underwent corrective surgery. Patients were divided into two groups according to BMI, BMI <25 (153 patients, mean age 71.9 years) and BMI ≥ 25 (overweight/obese, 81 patients, mean age 73.3 years). Radiographic results and perioperative complications were compared between the two groups. RESULTS: Surgical complications occurred in approximately 20% of patients in each group; complications did not significantly differ between the two groups. A greater proportion of patients in the BMI ≥ 25 group experienced mechanical failure and DJK, although the difference was not significant. Preoperative mean lumbar lordosis (LL), pelvic incidence (PI) minus LL, sacral slope (SS) and sagittal vertical axis (SVA) were similar in the BMI < 25 and BMI ≥ 25 groups. However, the BMI ≥25 group had lower mean LL (p = 0.015) and higher PI minus LL (p = 0.09) postoperatively. The BMI ≥25 groups also had significantly smaller LL (p = 0.026), smaller SS (p = 0.049) and higher SVA (p = 0.041) at the final follow-up, compared to the BMI < 25 group. CONCLUSIONS: In the present study, no difference in medical or surgical complications after ASD surgery was found between overweight/obese patients (BMI ≥ 25) and those with BMI < 25. However, correction of LL and SVA was smaller in patients with overweight/obese patients.


Asunto(s)
Lordosis , Adulto , Anciano , Índice de Masa Corporal , Humanos , Lordosis/diagnóstico por imagen , Lordosis/etiología , Estudios Retrospectivos , Sacro , Resultado del Tratamiento
6.
J Clin Med ; 10(20)2021 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-34682860

RESUMEN

Lateral lumbar interbody fusion (LLIF) is increasingly performed as corrective surgery for patients with adult spinal deformity (ASD). This paper compares the surgical results of LLIF and conventional posterior lumbar interbody fusion (PLIF)/transforaminal lumbar interbody fusion (TLIF) in ASD using a propensity score matching analysis. We retrospectively reviewed patients with ASD who received LLIF and PLIF/TLIF, and investigated patients' backgrounds, radiographic parameters, and complications. The propensity scores were calculated from patients' characteristics, including radiographic parameters and preoperative comorbidities, and one-to-one matching was performed. Propensity score matching produced 21 matched pairs of patients who underwent LLIF and PLIF/TLIF. All radiographic parameters significantly improved in both groups at the final follow-up compared with those of the preoperative period. The comparison between both groups demonstrated no significant difference in terms of postoperative pelvic tilt, lumbar lordosis (LL), or pelvic incidence-LL at the final follow-up. However, the sagittal vertical axis tended to be smaller in the LLIF at the final follow-up. Overall, perioperative and late complications were comparable in both procedures. However, LLIF procedures demonstrated significantly less intraoperative blood loss and a smaller incidence of postoperative epidural hematoma compared with PLIF/TLIF procedures in patients with ASD.

7.
BMJ Case Rep ; 14(4)2021 Apr 14.
Artículo en Inglés | MEDLINE | ID: mdl-33853820

RESUMEN

While the incidence of spondylodiscitis is rising because of longer life expectancy and the increasing use of immunosuppressant drug, indwelling devices and spinal surgeries, the fungal aetiology remains rare, sometimes affecting intravenous drug users. Candida spondylodiscitis is an extremely rare complication post aortic aneurysm repair. It is potentially fatal due to the risk of aneurysm rupture and septic complications. The growing problem of systemic diseases caused by Candida species reflects the enormous increase of patients at risk. The treatment of this complicated entity is challenging and often requiring a multidisciplinary team. We reported the rare case of Candida spondylodiscitis contiguous to infected aortic aneurysm in a 74-year-old male intravenous drug user, to the extent which the vertebral body bony destruction progressed to need one-stage posterior and anterior spinal fusion surgery with curettage. Our surgical intervention combined with prolonged course of antifungal therapy could successfully eradicate the infection and resolve the neurological deficits.


Asunto(s)
Aneurisma Infectado , Aneurisma de la Aorta Abdominal , Discitis , Consumidores de Drogas , Abuso de Sustancias por Vía Intravenosa , Anciano , Aneurisma Infectado/diagnóstico por imagen , Aneurisma Infectado/tratamiento farmacológico , Aneurisma Infectado/cirugía , Aneurisma de la Aorta Abdominal/complicaciones , Aneurisma de la Aorta Abdominal/diagnóstico por imagen , Aneurisma de la Aorta Abdominal/cirugía , Discitis/tratamiento farmacológico , Humanos , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Masculino , Abuso de Sustancias por Vía Intravenosa/complicaciones
8.
BMC Musculoskelet Disord ; 22(1): 357, 2021 Apr 16.
Artículo en Inglés | MEDLINE | ID: mdl-33863320

RESUMEN

BACKGROUND: Parkinson's disease (PD) has been found to increase the risk of postoperative complications in patients with adult spinal deformity (ASD). However, few studies have investigated this by directly comparing patients with PD and those without PD. METHODS: In this multicenter retrospective cohort study, we reviewed all surgically treated ASD patients with at least 2 years of follow-up. Among them, 27 had PD (PD+ group). Clinical data were collected on early and late postoperative complications as well as any revision surgery. Radiographic parameters were evaluated before and immediately after surgery and at final follow-up, including sagittal vertical axis (SVA), thoracic kyphosis, lumbar lordosis, sacral slope, and pelvic tilt. We compared the surgical outcomes and radiographic parameters of PD patients with those of non-PD patients. RESULTS: For early complications, the PD+ group demonstrated a higher rate of delirium than the PD- group. In terms of late complications, the rate of non-union was significantly higher in the PD+ group. Rates of rod failure and revision surgery due to mechanical complications also tended to be higher, but not significantly, in the PD+ group (p = 0.17, p = 0.13, respectively). SVA at final follow-up and loss of correction in SVA were significantly higher in the PD+ group. CONCLUSION: Extra attention should be paid to perioperative complications, especially delirium, in PD patients undergoing surgery for ASD. Furthermore, loss of correction and rate of non-union were greater in these patients.


Asunto(s)
Enfermedad de Parkinson , Fusión Vertebral , Adulto , Estudios de Seguimiento , Humanos , Enfermedad de Parkinson/complicaciones , Enfermedad de Parkinson/epidemiología , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Estudios Retrospectivos , Fusión Vertebral/efectos adversos
9.
BMC Musculoskelet Disord ; 22(1): 7, 2021 Jan 04.
Artículo en Inglés | MEDLINE | ID: mdl-33397347

RESUMEN

BACKGROUND: Thoracic ossification of ligamentum flavum (T-OLF), as one of the causes of thoracic myelopathy, is often combined with other spinal disorders. Concurrent lumbar spinal canal stenosis (LCS) is often obscured by symptoms due to T-OLF, leading to difficulty in identifying the origin of these neurological findings. It is common to be misdiagnosed or delayed diagnosis due to the complicated nature. We evaluated the prevalence, distribution, and clinical characteristics of OLF, especially in patients with LCS. METHODS: The authors performed a retrospective analysis of the outcomes of 61 patients who underwent thoracic surgeries performed for symptomatic T-OLF. In all the patients, whole spine lesions were evaluated preoperatively. We examined the factors related to poor outcomes (the recovery rate of the Japanese Orthopedic Association score for thoracic myelopathy is less than 40%) following OLF surgeries. We compared the clinical outcomes according to whether there was concurrent LCS, and determined the optimal surgical approach. RESULTS: The occurrence of T-OLF increased with age. Forty-six cases (75.4%) were considered to be tandem T-OLF and LCS (LCS group). An advanced age, and concurrent LCS were associated with a poor outcome after the surgery. The LCS group significantly included a greater number of elderly, and more light-weighted patients with Modic change in thoracic spine and a greater sagittal vertical axis, resulting in the lower neurological recovery. Additional lumbar surgery (13cases) effectively improved both the T-JOA and L-JOA scores (from 6.5 ± 2.0 points to 8.0 ± 1.8 points, p = 0.0406, and from 14.5 ± 4.7 points to 20.7 ± 2.6 points, p = 0.001, respectively) in OLF patients with LCS. CONCLUSIONS: T-OLF was highly associated with other spinal disorders. Poor outcomes in T-OLF surgery could be associated with age and concurrent LCS, and an additional surgery for another lumbar lesion significantly improved neurological findings in T-OLF patients.


Asunto(s)
Ligamento Amarillo , Osificación Heterotópica , Anciano , Descompresión Quirúrgica , Humanos , Ligamento Amarillo/diagnóstico por imagen , Ligamento Amarillo/cirugía , Osificación Heterotópica/diagnóstico por imagen , Osificación Heterotópica/epidemiología , Osteogénesis , Estudios Retrospectivos , Vértebras Torácicas/diagnóstico por imagen , Vértebras Torácicas/cirugía , Resultado del Tratamiento
10.
J Orthop Sci ; 26(5): 733-738, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-32868209

RESUMEN

BACKGROUND: Decompression through an anterior approach is theoretically effective for the surgical treatment of cervical spondylotic amyotrophy (CSA), because the pathology usually locates at the anterior side. However, most previous studies investigated posterior surgery or a mix of anterior surgery and posterior surgery in their investigation. Only a few small case series have investigated the surgical outcomes of anterior decompression and fusion (ADF). Therefore, we conducted a multicenter retrospective study that included patients who underwent ADF for proximal-type CSA. METHODS: We analyzed the outcomes of 77 consecutive spinal surgeries performed on proximal-type CSA patients who underwent ADF. Preoperative and postoperative manual muscle tests (MMT) and the patients' backgrounds, radiological findings, and complications were reviewed. We divided the cases into two groups, good-outcome group (MMT improvement â‰§ 2 or improved to MMT 5) and poor-outcome group (others) and evaluated the prognostic factors for outcomes. RESULTS: Of the 77 patients, 48 (62%) showed good neurological outcome. Multiple compressive lesions at anterior horn (AH) and/or ventral nerve roots (VNRs) were detected in 66 patients (85.7%) on the magnetic resonance images. The patients with a single compressive lesion at VNR or AH tended to show good neurological recovery when compare to those with multiple lesions. Age and duration of symptoms were related to the poor outcome in univariate analysis. Duration of symptoms was an independent factor associated with postoperative neurological outcome. The cut-off value for poor outcome was 7.0 months for the symptom duration (sensitivity: 79%, specificity: 54%, area under the curve: 0.69). CONCLUSIONS: Patients with proximal-CSA were more likely to have multiple compressive lesions at an AH and/or a VNR. The prognostic factor for poor neurological outcome was duration of symptoms of ≥7 months.


Asunto(s)
Fusión Vertebral , Espondilosis , Vértebras Cervicales/diagnóstico por imagen , Vértebras Cervicales/cirugía , Descompresión Quirúrgica , Humanos , Pronóstico , Estudios Retrospectivos , Espondilosis/complicaciones , Espondilosis/diagnóstico por imagen , Espondilosis/cirugía , Resultado del Tratamiento
11.
Spine (Phila Pa 1976) ; 45(17): 1185-1192, 2020 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-32205686

RESUMEN

STUDY DESIGN: A retrospective multicenter observational study. OBJECTIVE: To investigate correction surgeries that were performed in relatively aged patients in terms of mechanical complications (MCs) and their predictive factors. SUMMARY OF BACKGROUND DATA: The risk factors associated with MCs have not yet been well examined, especially in aged populations. METHODS: We retrospectively reviewed 230 surgically treated ASD patients with an average age of 72.2 years. Twenty-eight patients with ASD caused by vertebral fractures were excluded. The minimum follow-up was 2 years. Postoperative MCs were defined as proximal junction kyphosis, distal junction kyphosis, pseudoarthrosis, rod breakage, and vertebral fractures. We divided all the ASD patients into two groups: patients with MC (the MC (+) group) and patients without MC (the MC (-) group). Radiographic parameters were evaluated before and immediately after surgery. The SRS-Schwab ASD classification and global alignment and proportion (GAP) score were also evaluated. RESULTS: Of the 202 patients, 91 (45.0%) had MCs. The age at surgery was significantly higher in the MC (+) group than in the MC (-) group. Regarding radiographic parameters, postoperative global tilt (GT), pre- and postoperative thoracolumbar kyphosis (TLK), and postoperative thoracic kyphosis were significantly higher in the MC (+) group than in the MC (-) group. Other parameters, such as the proposed ideal alignment target of PI-LL<10, did not significantly affect MC rates. The GAP score was high in both groups and not significantly related to a higher rate of MC. Forward stepwise logistic regression indicated that the age at surgery, postoperative GT, and preoperative TLK were significant risk factors for MCs. CONCLUSION: Older age, higher postoperative GT, and higher pre and postoperative TLK can be risk factors for MCs. The GAP score was high in both groups and not significantly related to a higher rate of MC. LEVEL OF EVIDENCE: 4.


Asunto(s)
Fenómenos Biomecánicos/fisiología , Procedimientos Neuroquirúrgicos/efectos adversos , Complicaciones Posoperatorias/diagnóstico por imagen , Complicaciones Posoperatorias/fisiopatología , Enfermedades de la Columna Vertebral/diagnóstico por imagen , Enfermedades de la Columna Vertebral/cirugía , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Cifosis/diagnóstico por imagen , Cifosis/cirugía , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Masculino , Persona de Mediana Edad , Procedimientos Neuroquirúrgicos/tendencias , Complicaciones Posoperatorias/etiología , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Vértebras Torácicas/diagnóstico por imagen , Vértebras Torácicas/cirugía
12.
Spine Surg Relat Res ; 3(1): 43-48, 2019 Jan 25.
Artículo en Inglés | MEDLINE | ID: mdl-31435550

RESUMEN

INTRODUCTION: We describe 5 patients who underwent operative treatment for arachnoid web (AW) and discuss the postoperative clinical outcome in each case. AW is an extremely rare disease that causes cord compression and syringomyelia in the thoracic spine. To date, 14 cases only of AW have been reported, and the effect of surgical intervention on clinical and radiologic outcomes is unknown. METHODS: Five patients who underwent surgical treatment for AW were retrospectively reviewed. The clinical outcomes were evaluated using the thoracic Japanese Orthopaedic Association (T-JOA) score. Preoperative and postoperative images were reviewed. RESULTS: All the patients presented with spastic gait and numbness in the lower extremities. Two patients also presented with bladder-bowel dysfunction (BBD). AW, or the so-called "scalpel" sign, was seen dorsally in the thoracic spine on magnetic resonance imaging in all the patients. Syringomyelia adjacent to the web was observed in 4 patients. Fenestration and web resection without instrumentation was performed in all the cases. Overall, significant improvement was seen in locomotion and the total T-JOA score postoperatively. However, numbness in the lower extremities improved in 2 patients but was unchanged in 3 cases. BBD was ameliorated in 1 patient but remained unchanged in the other patient. CONCLUSIONS: Our experience suggests that surgical treatment, including the another patient and resection of the web, can correct the flow dynamics of cerebrospinal fluid and allow neurologic recovery, in particular locomotion, in patients with AW.

13.
Spine Surg Relat Res ; 2(3): 221-225, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-31440672

RESUMEN

INTRODUCTION: Pedicle subtraction osteotomy (PSO) is performed to correct sagittal plane deformity. This procedure is useful with revision cases in which the number of intact discs for correction is limited. METHODS: Forty-four patients (10 male and 34 female) with minimum follow-up of 2 years were reviewed; all had undergone PSO revision surgery for kyphosis following previous lumbar fusion surgery. The average age at operation was 72.8 years (range 42-85 years), and the average follow-up period was 4.1 years (2-9 years). The average fusion level was 7.5 (4-13 level), and the average previously fused level was 2.4 (1-7 level). RESULTS: The average operation time was 424 min, and average blood loss was 2880 g. The average JOA score of 14.0 before operation changed to 21.8 at 1-year follow-up and to 20.7 at final follow-up. The average recovery rate at final follow-up was 45.7%. Four patients underwent re-operations for proximal junctional kyphosis and 3 patients for rod fracture. The fusion rate was 88.6%, and 13 patients (29.5%) developed subsequent vertebral fracture. The average PI-LL (Pelvic incidence minus Lumbar lordosis) at pre-op of 52.9 degrees changed to 3.8 degrees at post-op, to 13.4 degrees at 1-year follow-up, and to 14.8 degrees at final follow-up. The average correction at the PSO site was 36.0 degrees at post-op, 36.7 degrees at 1-year follow-up, and 37.0 degrees at final follow-up. The average sagittal vertical axis at pre-op of 145.0 mm decreased to 51.2 mm at 1-year follow-up; however, it increased to 75.3 mm at final follow-up. CONCLUSION: PSO for correction of kyphosis following previous lumbar fusion surgery was an effective procedure without correction loss at the local osteotomy site; however, its surgical invasiveness and complication rate were high. Subsequent vertebral fracture, adjacent segment degeneration, and rod fracture contribute to deterioration of outcome that is evident at long-term follow-up.

14.
Hum Mol Genet ; 18(2): 227-40, 2009 Jan 15.
Artículo en Inglés | MEDLINE | ID: mdl-18923003

RESUMEN

Activating mutations in FGFR3 cause achondroplasia and thanatophoric dysplasia, the most common human skeletal dysplasias. In these disorders, spinal canal and foramen magnum stenosis can cause serious neurologic complications. Here, we provide evidence that FGFR3 and MAPK signaling in chondrocytes promote synchondrosis closure and fusion of ossification centers. We observed premature synchondrosis closure in the spine and cranial base in human cases of homozygous achondroplasia and thanatophoric dysplasia as well as in mouse models of achondroplasia. In both species, premature synchondrosis closure was associated with increased bone formation. Chondrocyte-specific activation of Fgfr3 in mice induced premature synchondrosis closure and enhanced osteoblast differentiation around synchondroses. FGF signaling in chondrocytes increases Bmp ligand mRNA expression and decreases Bmp antagonist mRNA expression in a MAPK-dependent manner, suggesting a role for Bmp signaling in the increased bone formation. The enhanced bone formation would accelerate the fusion of ossification centers and limit the endochondral bone growth. Spinal canal and foramen magnum stenosis in heterozygous achondroplasia patients, therefore, may occur through premature synchondrosis closure. If this is the case, then any growth-promoting treatment for these complications of achondroplasia must precede the timing of the synchondrosis closure.


Asunto(s)
Acondroplasia/metabolismo , Desarrollo Óseo , Sistema de Señalización de MAP Quinasas , Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/metabolismo , Displasia Tanatofórica/metabolismo , Acondroplasia/genética , Acondroplasia/fisiopatología , Animales , Proteínas Morfogenéticas Óseas/metabolismo , Diferenciación Celular , Células Cultivadas , Condrocitos/metabolismo , Condrogénesis , Humanos , MAP Quinasa Quinasa 1/genética , MAP Quinasa Quinasa 1/metabolismo , Ratones , Ratones Endogámicos C57BL , Ratones Transgénicos , Osteoblastos/metabolismo , Receptor Tipo 3 de Factor de Crecimiento de Fibroblastos/genética , Displasia Tanatofórica/genética , Displasia Tanatofórica/fisiopatología
15.
J Orthop Sci ; 10(2): 137-44, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-15815860

RESUMEN

The correlation between the insertion torque of a lumbar pedicle screw and the mechanical stability of the screw in the bone has been mentioned in in vitro studies. The purpose of this study was to confirm the factors affecting the insertion torque of such screws in vivo. Also, the contribution of insertion torque to the initial stability of the fusion area was to be analyzed in vivo. A series of 23 cases representing 50 lumbar vertebrae were included in this study, in which we examined bone mineral density using quantitative computed tomography (CT) prior to operation. Two screw shapes were utilized, with the insertion torque for each screw measured at two points in time. The correlation between insertion torque and mineral density was investigated. Screw positions were confirmed on postoperative CT scans, and the effect of the screw thread cutting into the cortex bone was investigated. Radiographic changes at three points during a period of 3 months were also measured, and we then evaluated the interrelations between these changes and insertion torque. Furthermore, the relation between insertion torque and instability at 3 months was investigated. Correlations of insertion torque and bone mineral density depended on screw shape. There was no correlation found with mineral density in the case of cylindrical screws. Insertion torque was not affected by the screw thread cutting into the cortex of bone. As for postoperative alignment changes, no definitive trends could be ascertained, and no interrelations with torque and alignment changes were observed. There is a possibility that insertion torque was related to early-stage stability, but no statistical relation could be determined.


Asunto(s)
Tornillos Óseos , Vértebras Lumbares/diagnóstico por imagen , Vértebras Lumbares/cirugía , Anciano , Anciano de 80 o más Años , Densidad Ósea , Diseño de Equipo , Femenino , Humanos , Cuidados Intraoperatorios , Masculino , Persona de Mediana Edad , Cuidados Posoperatorios , Radiografía , Factores de Tiempo , Torque
16.
J Orthop Sci ; 10(2): 152-9, 2005.
Artículo en Inglés | MEDLINE | ID: mdl-15815862

RESUMEN

To compare the motion of lumbar spondylolisthesis between the standing and decubitus positions and to identify the radiological parameters concerning segmental instability, the lumbar sagittal motion of 5 volunteers and 14 patients was recorded using video-fluoroscopy in both positions. Still images at three frames per second were captured, and the motion pattern was compared between the two positions. Patients were classified into two subgroups according to the degree of postural slip reduction. In the volunteer group, the motion patterns were not particularly different between the two positions. In the small postural reduction group, the motion patterns were not particularly different between the two positions, except in one patient for whom the range of motion (ROM) at the upper adjacent level increased in the decubitus position. In the large postural reduction group, a motion pattern change was observed. The ROM at the slip level in three patients increased, and in the remaining four patients the angle at the midpoint in ROM at the slip level shifted to the extension side in the decubitus position. This condition (anterior slip being reduced in the supine position, with disc angle and average disc height increased) is thought to result from anterior column deficiency and the vertical laxity of the surrounding soft tissues. A biomechanically stable fusion technique is recommended for surgical management.


Asunto(s)
Postura , Rango del Movimiento Articular , Espondilolistesis/diagnóstico por imagen , Espondilolistesis/fisiopatología , Adolescente , Adulto , Anciano , Fluoroscopía , Humanos , Persona de Mediana Edad , Grabación en Video
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...